Serum Endocan Correlated With Stage of Chronic Kidney Disease and Deterioration in Renal Transplant Recipients

Su, Yu-Chia; Shu, Kuo‐Hsiung; Hu, Cheng; Cheng, Chi‐Hung; Wu, Ming‐Ju; Yu, T.-M.; Chuang, Ya‐Wen; Huang, Shih Ting; Chen, C.-H.

doi:10.1016/j.transproceed.2013.10.057

Cited by 38 publications

(41 citation statements)

References 13 publications

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“…25 Endocan is a proteoglycan which is secreted by vascular endothelial cells and which can be considered as a marker of endothelial activation. 26 To the best of our knowledge, until today, only one study has been conducted which has shown that plasma endocan increased in chronic kidney disease patients and influenced all-cause mortality together with cardiovascular events. According to these results, endocan may influence both the inflammatory process and the endothelial function in the pathogenesis of many vascular disorders.…”

Section: Discussionmentioning

confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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Section: Discussionmentioning

confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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“…The findings from a study by Li et al [24] showed that the circulating endocan level could be used as a marker of acute rejection in RT patients. In another report, high levels of endocan were correlated with different stages of the CKD in RT patients [25]. These authors also observed that GFR loss was greater in the group with higher serum endocan levels [25].…”

Section: Discussionmentioning

confidence: 94%

“…In another report, high levels of endocan were correlated with different stages of the CKD in RT patients [25]. These authors also observed that GFR loss was greater in the group with higher serum endocan levels [25]. In addition, negative correlations have been described between the endocan levels and the eGFR and endothelial function in patients with CKD who had not undergone hemodialysis or peritoneal dialysis [13].…”

Section: Discussionmentioning

confidence: 99%

Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant

Souza

Oliveira

Laurindo

et al. 2016

International Journal of Nephrology

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Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r = 0.416; P = 0.001; pulse pressure: r = 0.412; P = 0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate (r = −0.388; P = 0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.

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“…Güzel et al [13] found a correlation between plasma endocan levels and thromboembolism. Endocan has been shown to be correlated with the estimated glomerular filtration rate and, as such, may indicate the stage of chronic kidney disease (CKD) [14]. Indeed, it has been hypothesized that endocan could become a useful marker for differentiating acute kidney injury from CKD [15].…”

Section: Introductionmentioning

confidence: 99%

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Perrotti¹,

Chenevier‐Gobeaux

Ecarnot³

et al. 2017

Cardiorenal Med

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Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD). Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Blood samples were tested at 4 time points (preoperatively and 6, 12, and 24 h after the end of surgery). Endocan, procalcitonin, and C-reactive protein plasma levels were compared between the two groups. Results: At 6 h, the patients with pulmonary infection had significantly higher levels of endocan than the patients without pulmonary infection (24.2 ± 15.6 vs. 6.4 ± 3.2 ng/mL; p = 0.03). A receiver operating characteristic curve analysis showed 80% sensitivity and 100% specificity for endocan to predict pulmonary infection (area under the curve 0.84), with a cutoff value of 15.9 ng/mL. The time saved by assessment of the endocan dosage compared to a clinical diagnosis of pulmonary infection was 47 h. Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.

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Serum Endocan Correlated With Stage of Chronic Kidney Disease and Deterioration in Renal Transplant Recipients

Cited by 38 publications

References 13 publications

Endocan Measurement for Active Behçet Disease

Endocan Measurement for Active Behçet Disease

Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

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