Serum elafin as a potential inflammatory marker in psoriasis

Elgharib, Ibrahim; Khashaba, Shrook A; Elsaid, Hanaa H.; Sharaf, M

doi:10.1111/ijd.14217

Cited by 29 publications

(32 citation statements)

References 20 publications

(20 reference statements)

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“…In vitro, Lcn2 stimulated human neutrophils to produce proinflammatory mediators such as IL-6, IL-8, TNF-α, and IL-1α via a specific receptor, 24p3R, on neutrophils [60]. Elgharib et al showed statistically significant correlation between serum elafin levels and Psoriasis Area and Severity Index (PASI) score [61].…”

Section: Other Ampsmentioning

confidence: 99%

Psoriasis and Antimicrobial Peptides

Takahashi

Yamasaki

2020

IJMS

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Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) such as β-defensin, S100, and cathelicidin are secreted from these cells and activate the innate immune system through various mechanisms to induce inflammation, thus participating in the pathogenesis of psoriasis. In particular, these antimicrobial peptides enhance the binding of damage-associated molecular patterns such as self-DNA and self-RNA to their receptors and promote the secretion of interferon from activated plasmacytoid dendritic cells and keratinocytes to promote inflammation in psoriasis. Neutrophil extracellular traps (NETs), complexes of self-DNA and proteins including LL-37 released from neutrophils in psoriatic skin, induce Th17. Activated myeloid dendritic cells secrete a mass of inflammatory cytokines such as IL-12 and IL-23 in psoriasis, which is indispensable for the proliferation and survival of T cells that produce IL-17. AMPs enhance the production of some of Th17 and Th1 cytokines and modulate receptors and cellular signaling in psoriasis. Inflammation induced by DAMPs, including self-DNA and RNA released due to microinjuries or scratches, and the enhanced recognition of DAMPs by AMPs, may be involved in the mechanism underlying the Köbner phenomenon in psoriasis.

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Section: Other Ampsmentioning

confidence: 99%

Psoriasis and Antimicrobial Peptides

Takahashi

Yamasaki

2020

IJMS

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“…The results presented by Elgharib et al were consistent with those of our research. The level of elafin was much higher in the patients than in the controls [23]. Alkemade et al also confirmed that the levels of serum and urine elafin were markers of psoriasis and the activity of the disease.…”

Section: Discussionmentioning

confidence: 86%

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris

Holmannová

Borský

Borská

et al. 2020

IJMS

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Background: Psoriasis is a pathological condition characterized by immune system dysfunction and inflammation. Patients with psoriasis are more likely to develop a wide range of disorders associated with inflammation. Serum levels of various substances and their combinations have been associated with the presence of the disease (psoriasis) and have shown the potential to reflect its activity. The aim of the present study is to contribute to the elucidation of pathophysiological links between psoriasis, its pro-inflammatory comorbidity metabolic syndrome (MetS), and the expression of clusterin and elafin, which are reflected in the pathophysiological “portfolio” of both diseases. Material and methods: Clinical examinations (PASI score), ELISA (clusterin, elafin), and biochemical analyses (parameters of MetS) were performed. Results: We found that patients with psoriasis were more often afflicted by MetS, compared to the healthy controls. Clusterin and elafin levels were higher in the patients than in the controls but did not correlate to the severity of psoriasis. Conclusion: Our data suggest that patients with psoriasis are more susceptible to developing other systemic inflammatory diseases, such as MetS. The levels of clusterin and elafin, which are tightly linked to inflammation, were significantly increased in the patients, compared to the controls, but the presence of MetS in patients did not further increase these levels.

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“…High circulating elafin levels reflect increased T cell-mediated immune activity. Similarly, circulating elafin levels are positively correlated with disease severity in patients with adaptive immune diseases (psoriasis and graft-vs-host disease) (Elgharib et al, 2019, Paczesny et al, 2010. Elafin-dependent IFN, IL-5, IL-12 p70, IL-2, IL-15, and TNF are not associated with the presence of intestinal strictures, suggesting that fibrogenesis are not driven by these elafin-dependent cytokines ( Figure 1E).…”

Section: Discussionmentioning

confidence: 90%

High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures

Wang

Ortiz

Fontenot

et al. 2019

Preprint

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AbstractObjectiveNearly 33% of Crohn’s disease (CD) patients develop intestinal strictures. Antimicrobial peptide or protein expression is associated with disease activity in inflammatory bowel disease (IBD) patients. Circulating blood cells and intestine of IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. However, the association between elafin and CD-associated intestinal stricture is unknown. We hypothesize the elafin expression in stricturing CD patients is abnormal. We determined the expression of elafin in blood, intestine, and mesenteric fat in IBD patients.MethodsHuman colonic and mesenteric fat tissues and serum samples were collected from the Cedars-Sinai Medical Center and UCLA, respectively.ResultsHigh serum elafin levels were associated with a significantly elevated risk of intestinal stricture in CD patients. Machine learning algorithm using serum elafin levels and clinical data identified stricturing CD patients with high accuracy. Serum elafin levels had weak positive correlation with clinical disease activity (Partial Mayo Score and Harvey Bradshaw Index) in IBD patients. Ulcerative colitis (UC) patients had high serum elafin levels, but the increase was not associated with endoscopic Mayo score. Colonic elafin mRNA and protein expression were not associated with clinical disease activity in IBD patients, while stricturing CD patients had low colonic elafin expression. Mesenteric fat in stricturing CD patients had significantly increased elafin mRNA expression, which may contribute to high circulating elafin level.ConclusionHigh serum elafin levels and adipose elafin expression are associated with intestinal strictures, which may help identify intestinal strictures in CD patients.

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Serum elafin as a potential inflammatory marker in psoriasis

Abstract: Elafin represents a mirror for psoriasis severity and inflammatory state.

Cited by 29 publications

References 20 publications

Psoriasis and Antimicrobial Peptides

Psoriasis and Antimicrobial Peptides

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris

High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures

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