Serum DJ-1/PARK 7 Is a Potential Biomarker of Choroidal Nevi Transformation

Bande, Manuel Febrero; Santiago, Maria; Blanco, Marı́a José; Mera, Purificacion; Capeáns, C.; Rodríguez‐Álvarez, María Xosé; Pardo, María; Piñeiro, Antonio

doi:10.1167/iovs.11-7948

Cited by 23 publications

(24 citation statements)

References 40 publications

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“…Its expression is correlated with the transformation and progression of esophageal squamous cell carcinoma. 47 A recent study, Bande et al, 48 finds that elevated serum levels of PARK7 are associated with choroidal nevi transformation risk factors. However, an up-regulation of CAPZA1, PDIA3, SELENBP1, and PARK7 during metastasis, as obtained within our 2D DIGE study, is not reflected in our immunohistochemical analysis.…”

Section: Discussionmentioning

confidence: 98%

Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not

Linge

Kennedy²,

O'Flynn

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 98%

Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not

Linge

Kennedy²,

O'Flynn

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…All the latter factors require tissue sampling, limiting their use in determining the high-risk features of poor prognosis in uveal melanoma. On this basis, Bande et al [45] reported that elevated serum levels of DJ-1 were correlated with known clinical risk factors of nevi growth, and suggested that may be used as a potential biomarker of malignancy. In our study, the mean adiponectin level of the choroidal nevus group (9.2 µg/dl) was found to be lower than the cut-off level of adiponectin determined for uveal melanoma (10.7 µg/dl).…”

Section: Discussionmentioning

confidence: 99%

Serum adiponectin, insulin resistance, and uveal melanoma

Sevim

Kıratlı

2016

Melanoma Research

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To investigate the status of insulin resistance, metabolic syndrome, dyslipidemia, and serum adiponectin levels in patients with uveal melanoma and choroidal nevus were investigated. Our study included 86 patients with uveal melanoma, 38 patients with choroidal nevus, and 86 controls. Uveal melanomas were classified as small, medium, and large on the basis of Collaborative Ocular Melanoma Study (COMS) criteria. Patients with uveal melanoma had significantly higher homeostatic model assessment scores compared with patients with choroidal nevus (P<0.001). Patients with uveal melanoma and choroidal nevus had significantly lower levels of serum adiponectin compared with controls (P<0.001). Patients with uveal melanoma who developed systemic metastases had significantly lower levels of serum adiponectin levels compared with patients with nonmetastases during follow-up (P=0.018). When the largest tumors (COMS III) were compared, ciliary body melanomas were associated with significantly lower levels of serum adiponectin than choroidal melanomas. In patients who were treated with enucleation, epitheloid predominant and mixed cell-type tumors were associated with lower levels of serum adiponectin compared with tumors with spindle cell type, but this did not reach statistical significance. By providing an antiapoptotic and proangiogenic environment, low serum adiponectin levels and insulin resistance may play a role in promoting the growth of uveal melanocytic tumors and may contribute toward a more aggressive clinical course, adversely affecting the prognosis.

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“…DJ-1 is an oncoprotein secreted by cancer cells, already identified as a potential diagnostic and prognostic biomarker for breast cancer, 9 melanoma, 10 and pancreatic cancer 11 and that, recently, was associated with EC pathogenesis and progression. 12 …”

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confidence: 99%

DJ-1 in Endometrial Cancer: A Possible Biomarker to Improve Differential Diagnosis Between Subtypes

Morelli¹,

Scumaci²,

Cello³

et al. 2014

Int J Gynecol Cancer

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Serum DJ-1/PARK 7 Is a Potential Biomarker of Choroidal Nevi Transformation

Abstract: Elevated serum levels of DJ-1 are associated with choroidal nevi transformation risk factors. Therefore, DJ-1 appears to be a promising factor for predicting the growth of choroidal nevi and may be a potential biomarker of malignancy.

Cited by 23 publications

References 40 publications

Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not

Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not

Serum adiponectin, insulin resistance, and uveal melanoma

DJ-1 in Endometrial Cancer: A Possible Biomarker to Improve Differential Diagnosis Between Subtypes

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