Serum Disease of the Nervous System

Kraus, Walter M.

doi:10.1001/archneurpsyc.1937.02260170063003

Cited by 22 publications

(3 citation statements)

References 6 publications

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Section: Human Immune Complex Diseasementioning

confidence: 99%

“…Like disseminated vasculomyelinopathy, the disease is monophasic, with multilevel involvement throughout the nervous system. Most common is mild meningoencephalitis; headache, nausea, and vomiting are common at onset, 50% of patients have lymphocytic pleocytosis [22], and mild encephalopathy is almost always present 1301. Papilledema, aphasia, hemiplegia, hemianopia, coma, chorea, cerebellar syndromes, cranial neuropathies, radiculoneuritis (especially brachial neuritis), the Guillain-Barr6 syndrome, and acute transverse myelitis have all been reported in addition [ 2 2 , 24, 301.…”

Section: Human Immune Complex Diseasementioning

confidence: 99%

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Disseminated vasculomyelinopathy: An immune complex disease

Reik

1980

Annals of Neurology

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The numerous nervous system abnormalities which follow antecedent infections and immunization appear to share a common pathogenesis involving the immune system. Pathologically, a small vessel vasculopathy involving arterioles and capillaries as well as venules in both gray and white matter is the earliest and most consistent change. Perivascular demyelination appears to develop subsequently. Delayed hypersensitivity to myelin basic protein may not adequately account for these changes. Humoral immunity may be involved instead. I postulate that antigen-antibody complexes, formed following the introduction of foreign antigen by infection or inoculation, cause vascular injury with secondary damage to myelin. There is considerable evidence that circulating immune complexes are present in some postinfectious nervous system disorders, as are associated systemic features which suggest immune complex disease. Similar clinical and pathological nervous system changes occur in a variety of disorders in which circulating immune complexes are thought to cause vascular injury.

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Section: Human Immune Complex Diseasementioning

confidence: 99%

Section: Human Immune Complex Diseasementioning

confidence: 99%

Disseminated vasculomyelinopathy: An immune complex disease

Reik

1980

Annals of Neurology

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“…Subsequently Dyke (1918) reported a similar case in this country, while the subject has attracted much attention in France, notably by Lhermitte (1919, 1938), and, latterly, in America and elsewhere (Kraus and Chaney, 1937). Allen (1931) reviewed forty-two reported examples then extant in the literature, and he described the second case (which followed scarlatina antitoxin administration) to appear in this country.…”

mentioning

confidence: 97%