Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta

Niskar, Amanda Sue; Needham, Larry L.; Rubin, Carol; Turner, Wayman E.; Martin, Colleen; Patterson, Donald G.; Hasty, Lisa A.; Wong, Lee Yang; Marcus, Michele

doi:10.1016/j.chemosphere.2008.10.005

Cited by 49 publications

(29 citation statements)

References 40 publications

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“…It is known that endometriosis is more common in urban rather than rural settings, potentially due to environmental contamination (35). Some studies suggest an association between certain dioxins, polychlorinated biphenyls (PCBs), and endometriosis (18,20) whereas other studies have failed to find a clear association (36,37). Diet might have a role in the etiology of endometriosis, but few studies have investigated this.…”

Section: Discussionmentioning

confidence: 95%

Heritability of endometriosis

Saha

Pettersson

Svedberg

et al. 2015

Fertility and Sterility

142

104

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Section: Discussionmentioning

confidence: 95%

Heritability of endometriosis

Saha

Pettersson

Svedberg

et al. 2015

Fertility and Sterility

142

104

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“…A case-control study in Italy with 80 cases and 78 controls found an increased risk for women exposed to the highest tertile of DDE compared to the lowest (OR=2.14; 95% CI, 0.93-4.93), while no association was seen for HCB [25]. Lebel et al [14] in 1998 reported no differences in the mean plasma concentration for eleven chlorinated pesticides, including aldrin, p,p ′-DDE, HCB, mirex, and t -nonachlor considered in our analyses. One possible explanation for their negative finding could be the authors' matching on indication for laparoscopy which may have inadvertently matched on disease status [26].…”

Section: Discussionmentioning

confidence: 99%

“…A case-control study in Atlanta aimed at measuring any potential association between serum dioxin levels as expressed by total toxic equivalence (TEQ) and serum total PCBs, as calculated by the sum of concentration of 36 congeners in women and endometriosis, found null results. The authors did not however examine the chemicals we examined in this study [14]. Limited attention has focused on persistent organochlorine pesticides (OCPs) and their association with endometriosis, despite their sharing a similar chemical structure with dioxins and PCBs and their ubiquitous presence in the environment.…”

Section: Introductionmentioning

confidence: 99%

Organochlorine pesticides and endometriosis

Cooney

Louis

Hediger

et al. 2010

Reproductive Toxicology

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Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cc of blood for toxicologic analysis and surgeons completed operative reports regarding the presence of endometriosis. Gas chromatography with electron-capture was used to quantify (ng/g serum) six OCPs. Logistic regression was utilized to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for individual pesticides and groups based on chemical structure adjusting for current cigarette smoking and lipids. The highest tertile of aromatic fungicide was associated with a five-fold risk of endometriosis (aOR = 5.3; 95% CI, 1.2-23.6) compared to the lowest tertile. Similar results were found for t-nonachlor and HCB. These are the first such findings in a laproscopic cohort that suggest an association between OCP exposure and endometriosis. More prospective studies are necessary to ensure temporal ordering and confirm these findings.

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“…Despite evidence of endocrine-disruptive properties of OCPs, the impact of these chemicals on endometriosis risk remains unclear; prior epidemiologic studies investigating serum concentrations of OCPs in relation to endometriosis have had conflicting results (Cooney et al 2010; Lebel et al 1998; Niskar et al 2009; Porpora et al 2009; Quaranta et al 2006; Tsukino et al 2005). These studies were conducted primarily among women undergoing surgical evaluation by laparoscopy.…”

Section: Introductionmentioning

confidence: 99%

Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case–Control Study

Upson

Roos

Thompson

et al. 2013

Environ Health Perspect

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Background: Endometriosis is considered an estrogen-dependent disease. Persistent environmental chemicals that exhibit hormonal properties, such as organochlorine pesticides (OCPs), may affect endometriosis risk.Objective: We investigated endometriosis risk in relation to environmental exposure to OCPs.Methods: We conducted the present analyses using data from the Women’s Risk of Endometriosis (WREN) study, a population-based case–control study of endometriosis conducted among 18- to 49-year-old female enrollees of a large health care system in western Washington State. OCP concentrations were measured in sera from surgically confirmed endometriosis cases (n = 248) first diagnosed between 1996 and 2001 and from population-based controls (n = 538). We estimated odds ratios (OR) and 95% CIs using unconditional logistic regression, adjusting for age, reference date year, serum lipids, education, race/ethnicity, smoking, and alcohol intake.Results: Our data suggested increased endometriosis risk associated with serum concentrations of β-hexachlorocyclohexane (HCH) (third vs. lowest quartile: OR = 1.7; 95% CI: 1.0, 2.8; highest vs. lowest quartile OR = 1.3; 95% CI: 0.8, 2.4) and mirex (highest vs. lowest category: OR = 1.5; 95% CI: 1.0, 2.2). The association between serum β-HCH concentrations and endometriosis was stronger in analyses restricting cases to those with ovarian endometriosis (third vs. lowest quartile: OR = 2.5; 95% CI: 1.5, 5.2; highest vs. lowest quartile: OR = 2.5; 95% CI: 1.1, 5.3).Conclusions: In our case–control study of women enrolled in a large health care system in the U.S. Pacific Northwest, serum concentrations of β-HCH and mirex were positively associated with endometriosis. Extensive past use of environmentally persistent OCPs in the United States or present use in other countries may affect the health of reproductive-age women.Citation: Upson K, De Roos AJ, Thompson ML, Sathyanarayana S, Scholes D, Barr DB, Holt VL. 2013. Organochlorine pesticides and risk of endometriosis: findings from a population-based case–control study. Environ Health Perspect 121:1319–1324; http://dx.doi.org/10.1289/ehp.1306648

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Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta

Cited by 49 publications

References 40 publications

Heritability of endometriosis

Heritability of endometriosis

Organochlorine pesticides and endometriosis

Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case–Control Study

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