Serum-Digoxin Concentrations During Treatment With Different Preparations

Influence of Dispersion Method on Dissolution Rate and Bioavailability of Digoxin from Triturations and Compressed Tablets II

“…The variation in bioavailability of digoxin from tablet dosage forms was recently reported (1)(2)(3)(4)(5). Such variations were also found in different lots of the formulated product made by the same manufacturer (1,6,7).…”

“…Such variations were also found in different lots of the formulated product made by the same manufacturer (1,6,7). Several poorly absorbed preparations were reported (1)(2)(3)(4) to be therapeutically ineffective or associated with digoxin levels below the therapeutic range. The hydrophobicity and poor aqueous solubility of digoxin account to a significant degree for these variations.…”

An Overview of the Analysis and Interpretation of Bioavailability Studies in Man

“…Table I summarizes results of Manninen et al (2). 19 patients who were stabilized to digoxin, 0.25 mg, tablet 'A', were studied by measuring plasma levels of digoxin for a few days, then they were switched to brand 'B' tablets at the same label doses.…”

Digoxin Degradation in Acidic Dissolution Medium

“…The bioavailability of digoxin preparations was reported to vary significantly among brands and batches (1)(2)(3)(4)(5). Many studies revealed the correlation between the dissolution rate and the bioavailability of digoxin, but little attempt was made to separate digoxin from its degraded glycosides (6)(7)(8).…”