Serum DDT and DDE Levels in Pregnant Women of Chiapas, Mexico

Koepke, Ruth; Warner, Marcella; Petreas, Myrto; Cabria, Angeles; Danis, R; Hernández-Ávila, Mauricio; Eskenazi, Brenda

doi:10.1080/00039890409603434

Cited by 29 publications

(25 citation statements)

References 34 publications

(50 reference statements)

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“…This difference could be related to the highly widespread of use of DDT in the coastal areas of Mexico, where malaria is endemic (Centro Nacional de Salud Ambiental, 2000;Portillo-Galva´n et al, 2002). Our study finds that the concentrations of p,p 0 -DDE are consistent with other studies performed in Mexican women of reproductive age (Yan˜ez et al, 2002;Flores-Luevano et al, 2003;Koepke et al, 2004;Torres-Sanchez et al, 2007). A review article by Torres-Sanchez and Lopez-Carrillo (2007) in Mexico indicates a possible link between DDE maternal contaminant concentrations and possible damage to reproductive health, and alteration in the psychomotor development of children exposed in utero, even though many gaps in knowledge exist concerning reproductive effects (Torres-Sanchez and Lo´pez Carrillo, 2007).…”

Section: Discussionsupporting

confidence: 82%

“…The DDT/DDE ratio was calculated by dividing plasma levels of p,p 0 -DDT by p,p 0 -DDE. In the human body, DDE half-life is longer than that of DDT; consequently, a higher DDT/DDE ratio may indicate a more recent exposure, whereas a lower DDT/DDE ratio may indicate a more distant/weathered exposure (Trichopoulus et al, 1995) (Koepke et al, 2004). Tests for normality were performed on these data and the contaminants did not show a normal distribution.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent organic pollutant concentrations in first birth mothers across Mexico

Rodríguez-Dozál

Rodríguez

Hernández-Ávila

et al. 2011

J Expo Sci Environ Epidemiol

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This project was initiated by the North America Commission for Environmental Cooperation (CEC). Its main purpose was to obtain an initial profile on pregnant woman's exposure to persistent organic pollutants (POPs) in North America (Canada, the United States and Mexico). Persistent organic pollutants are transferred to the fetus via the placenta during the pregnancy or to the infant via maternal milk; therefore, the pregnant woman's body burden is important because of the higher exposures and potential health effects in the fetus and infant. This paper presents the results from 240 pregnant women in 10 Mexican cities, and includes the concentrations of various POPs such as polychlorinated biphenyls (PCBs), organochlorine pesticides and polychlorinated dibenzo dioxins and furans (PCDDs and PCDFs) in maternal plasma. We found concentrations of p,p 0 -DDE in maternal samples from Coatzacoalcos to be B60% higher than those found in Ciudad Obregon, which had the second highest concentration. Pregnant women from Merida had higher mean concentrations of PCBs than all women in other regions. Results for PCDDs and PCDFs plus dioxin-like PCBs data were only available on the basis of composite samples, and their concentrations are similar in most cities except for Coatzacoalcos, which had more than double the concentration found in other cities. Although this study provides useful information on the variability of POPs in specific populations and possible regional/local differences, these results cannot be generalized to the entire Mexican population because of differences in age, gender, sources of exposure and nonrandom nature of the sample.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Persistent organic pollutant concentrations in first birth mothers across Mexico

Rodríguez-Dozál

Rodríguez

Hernández-Ávila

et al. 2011

J Expo Sci Environ Epidemiol

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“…The median DDE concentrations were much lower among the Faroese women than in a study of pregnant Mexican women in 1998 [38]. The median PCB concentrations in Cohorts 1 and 3 were higher than among American adults in the NHANES 2001–2002 data and among women delivering in two eastern Slovakian areas in 2002–2004, whereas, in Cohort 5, the median PCB concentration was higher than in NHANES, but lower than in one of the two Slovakian areas [39,40].…”

Section: Discussionmentioning

confidence: 96%

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Timmermann¹,

Choi

Petersen

et al. 2017

International Journal of Circumpolar Health

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This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.

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“…Koepke et al 2004 reportaron concentraciones de DDT y DDE en suero sanguíneo de mujeres embarazadas de Tapachula, Chiapas con variaciones de 0.05 a 23.1 µg/g y de 0.11 a 41.9 µg/g, respectivamente. Madres embarazadas residentes de Veracruz presentaron concentraciones de DDE y DDT en suero sanguíneo en niveles que variaron desde concentraciones por debajo del límite de detección del método a 0.98 µg/g y de 0.24 a 20.85 µg/g, respectivamente (Waliszewski et al 2000).…”

Section: Exposición En Mujeres En Edad Reproductivaunclassified

Estado Actual De La Investigación Sobre Plaguicidas en México

Hernández

Leyva-Morales

Rodríguez

et al. 2018

Rev. Int. Contam. Ambie.

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Palabras Clave: patrón de uso, exposición laboral, ecosistemas, contaminación, agricultura RESUMENEl presente trabajo analiza la investigación que se ha llevado a cabo en México con relación al uso y efecto de los plaguicidas en el ambiente y salud humana. Se revisaron 394 artículos publicados en los últimos 20 años en revistas indizadas o arbitradas. Las publicaciones se agruparon en 7 temas principales: 1) patrón de uso de plaguicidas, 2) efectos en el ambiente; 3) estudios ecotoxicológicos; 4) exposición en población humana; 5) residuos en alimentos; 6) toxicología de plaguicidas (estudios in vitro e in vivo); y 7) bioplaguicidas y biorremediación. El análisis de estas investigaciones indican que actualmente se utilizan Plaguicidas Altamente Peligrosos (PAPs) en las zonas agrícolas del país, su uso histórico y actual se relaciona con efectos negativos en ecosistemas terrestres y costeros, se han reportado efectos en la salud de los trabajadores agrícolas y sus familias, tales como alteraciones hematológicas, hormonales, daños genéticos, alteraciones del comportamiento y daños celulares; los niños constituyen el grupo más vulnerable a la exposición, además se han documentado daños genéticos, reproductivos y neuronales en modelos celulares y en organismos de laboratorio y se reportan residuos en alimentos como leche, hortalizas y granos. Como medidas de mitigación, se documentan procesos de biorremediación de suelos y agua contaminada,

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Serum DDT and DDE Levels in Pregnant Women of Chiapas, Mexico

Cited by 29 publications

References 34 publications

Persistent organic pollutant concentrations in first birth mothers across Mexico

Persistent organic pollutant concentrations in first birth mothers across Mexico

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Estado Actual De La Investigación Sobre Plaguicidas en México

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