Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders

Yamamoto, Tetsuya; Yoneda, Kazunori; Ueta, Eisaku; Osaki, Tokio

doi:10.1016/0030-4220(94)90087-6

Cited by 65 publications

(80 citation statements)

References 60 publications

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“…Khan et al revealed that unstimulated OLP lesional T cells secreted IFN-γ in vitro, but not found the secretion of IL-4, IL-10, and TGF-β1 [17]. Yamamoto et al detected about 20 pg/ml of interleukin-4 in serum from one third to one fourth of patients with oral lichen planus and more than 10 pg/ml of interleukin-6 in all [36]. And they also noted that more IFN-γ, IL-6, and TNF-α were generated by tissueinfiltrating mononuclear cells (TIMCs) of OLP [37].…”

Section: Discussionmentioning

confidence: 96%

IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

et al. 2009

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Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) represent T helper 1 (Th1) and T helper 2 (Th2) cytokines involved in oral lichen planus (OLP), respectively. This study was to investigate the expression profile of IFN-gamma and IL-4 in saliva of OLP patients. Seventy-nine ethnic Chinese patients with OLP were recruited for this study, together with 41 age-sex-matched healthy volunteers served as control group. IFN-gamma and IL-4 levels in whole unstimulated saliva were screened by enzyme linked immunosorbent assay. OLP patient showed a low-level IFN-gamma but high-level IL-4 expression profile in saliva, with a lower ratio of salivary IFN-gamma/IL-4 compared to healthy controls. With regards to subtypes, salivary IL-4 level in erythematous/ulcerative group was significantly higher than that in reticular group. Imbalance of Th1/Th2 cytokines with Th2-predominant profile in saliva may be involved in OLP. Salivary IL-4 level may be a fine biomarker reflecting the severity of OLP.

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Section: Discussionmentioning

confidence: 96%

IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

et al. 2009

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“…Excessive or unopposed production of these cytokines in response to a local stimulus could be an important aetiological factor in RAS and could explain the elevated IL-6 plasma levels reported in this condition. 9 In turn, these cytokines are likely to induce production of other cytokines, such as TNF, that may also promote the disease process. It is notable that corticosteroids and thalidomide, two of the most effective therapeutic agents in RAS, are inhibitors of IL-1␤ and IL-6 production.…”

Section: Genes and Immunitymentioning

confidence: 99%

“…[6][7][8] Indeed, elevated levels of TNF␣, interferon-␥, IL-2, IL-4 and IL-5 have been detected in ulcer tissue 7,8 and raised levels of IL-6 in the circulation. 9 It has been suggested that RAS is precipitated by local trauma in an individual genetically predisposed to an exaggerated or abnormal cytokine cascade. In turn, this leads to cytokine or cell-mediated damage to focal areas of the oral mucosa.…”

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confidence: 99%

IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS)

et al. 2002

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“…10 High serum levels of TNF-a were detected in all patients with OLP in comparison with its hardly detectable levels in control subjects. 11 Simultaneously with the expression of other pro-inflammatory and anti-inflammatory cytokines mRNAs, all the OLP lesions have been shown to contain cells with mRNA for TNF-a. 12 In this report we present data characterizing the pattern of TNF-a production in whole saliva of patients with OLP.…”

Section: Introductionmentioning

confidence: 99%

Salivary levels of tumor necrosis factor‐α in oral lichen planus

Pezelj-Ribarić

Pršo

Abram

et al. 2004

Mediators of Inflammation

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OBJECTIVE: Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder. AIM: Our study was undertaken to quantify the salivary levels of pro-inflammatory tumor necrosis factor-alpha (TNF-alpha) in the reticular and the erosive/atrophic forms of OLP, compared with age-matched healthy control volunteers. SUBJECTS AND METHODS: Whole saliva from 40 patients with active lesions of OLP, as well as from 20 healthy persons, was investigated for the presence of TNF-alpha by enzyme immunoassay. RESULTS: Salivary TNF-alpha levels were significantly increased in patients with OLP in comparison with healthy subjects. The presence of TNF-alpha showed positive correlation to clinical forms of OLP, being significantly higher in the erosive/atrophic type than in the reticular type of disease. CONCLUSION: Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. In patients with OLP, TNF-alpha levels in saliva are elevated, correlating with the severity of illness. Salivary TNF-alpha analysis may be a useful diagnostic tool and a potential prognostic marker in OLP.

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Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders

Cited by 65 publications

References 60 publications

IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS)

Salivary levels of tumor necrosis factor‐α in oral lichen planus

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