Serum cytokine profiles as predictors of asthma control in adults from the EGEA study

Akiki, Zeina; Rava, Marta; Gil, Oscar Diaz; Pin, Isabelle; Moual, Nicole Le; Siroux, Valérie; Guerra, Stefano; Chamat, Soulaïma; Matran, Régis; Fitó, Montserrat; Salameh, Pascale; Nadif, Rachel

doi:10.1016/j.rmed.2017.03.002

Cited by 20 publications

(16 citation statements)

References 36 publications

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“…This inhibition is confirmed in IL-1RA knockout asthmatic mice, where Th2 cell activation and AHR are increased significantly compared with wild type [108]. In addition, the high levels of IL-1RA in asthmatic patients are associated with lower risk of asthmatic exacerbations [83]. Interestingly, glucocorticoids exert some of its action through inhibition of IL-1 secretion together with upregulation of IL-1RA expression [111,112], which indicates the protective role of IL-1RA in asthma and its efficiency as a candidate for asthma treatment [113].…”

Section: Interleukin-1 Receptor Antagonist (Il-1ra)mentioning

confidence: 65%

“…IL-10, also, decreases eosinophilia [75][76][77][78][79][80][81][82] by suppressing their survival [79] or by reducing IFN-γ production; which ameliorates eosinophilic recruitment [75], and by suppressing Th2 cytokines. In addition, the high levels of IL-10 in serum of asthmatic patients are associated with lower risk of asthmatic exacerbations [83]. Interestingly, steroids exert some of their anti-inflammatory activity through stimulation of IL-10 secretion [73,84].…”

Section: Il-10mentioning

confidence: 99%

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Alternatively activated macrophages; a double-edged sword in allergic asthma

et al. 2020

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Background: Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which is the most common chronic respiratory disease of both adults and children. Macrophages activated by Th1 cells are known as M1 macrophages while those activated by IL-4 and IL-13 are called alternatively activated macrophages (AAM) or M2 cells. AAM are subdivided into four distinct subtypes (M2a, M2b, M2c and M2d), depending on the nature of inducing agent and the expressed markers. Body: IL-4 is the major effector cytokine in both alternative activation of macrophages and pathogenesis of asthma. Thus, the role of M2a macrophages in asthma is a major concern. However, this is controversial. Therefore, further studies are required to improve our knowledge about the role of IL-4-induced macrophages in allergic asthma, through precisive elucidation of the roles of specific M2a proteins in the pathogenesis of asthma. In the current review, we try to illustrate the different functions of M2a macrophages (protective and pathogenic roles) in the pathogenesis of asthma, including explanation of how different M2a proteins and markers act during the pathogenesis of allergic asthma. These include surface markers, enzymes, secreted proteins, chemokines, cytokines, signal transduction proteins and transcription factors. Conclusions: AAM is considered a double-edged sword in allergic asthma. Finally, we recommend further studies that focus on increased selective expression or suppression of protective and pathogenic M2a markers.

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Section: Interleukin-1 Receptor Antagonist (Il-1ra)mentioning

confidence: 65%

Section: Il-10mentioning

confidence: 99%

Alternatively activated macrophages; a double-edged sword in allergic asthma

et al. 2020

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“…High serum levels of IL-1RA have been shown to correlate with lower risk of worsening asthma control and attacks in adults (41). In contrast, serum IL-1RA may be elevated during acute asthma exacerbations in a pediatric cohort compared with those with stable asthma (42).…”

Section: Discussionmentioning

confidence: 99%

IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation

Godwin¹,

Reeder²,

Garth³

et al. 2019

JCI Insight

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“…We hypothesized that in middle‐aged people with asthma, serum cytokines might predict future asthma persistence beyond 44 years. Published studies regarding these potential associations are largely limited to childhood asthma, with only the Epidemiological study on the Genetics and Environment of Asthma (EGEA study) assessing cytokines profiles and asthma status longitudinally in adults, where they found patients with “high IL‐1Ra and high IL‐10” serum cytokine profiles had lower risks of worsening asthma control 4 …”

Section: Characteristics Overall Late‐onseta Early‐onseta P B N =mentioning

confidence: 99%