Serum Creatinine Phosphokinase [Cpk] an Early Marker in Human Leptospirosis

Abstract

Introduction: Leptospirosis is zoonotic disease worldwide caused by genus Leptospira. It is characterized by non-specific clinical presentation with broad spectrum manifestations. Due to unreliable, unsophisticated diagnostic techniques, misdiagnosis is not uncommon & leads to endemic. Aims and objective: Evaluate hepatic dysfunction & correlation between CPK and other liver enzymes in Icteric & Anicteric group. Material and Methods: Total 170 subjects were examined by clinician & grouped in Icteric, Anicteric and healthy controls. Blood samples of all subjects were analyzed for Liver profile & IgM antibodies. The clinical finding includes myalgia, bilateral congectival suffusion, jaundice, abdominal cramps, albuminuria, hematuria & rashes on body were reported. Results: Male patients are more prone to Leptospira infection due to various occupational exposures. Serological tests comes positive until the second week, by that time organism implicate Liver and Renal function. Measurement of elevated CPK level and increased Faine's score will predict early diagnosis of disease. Morbidity & mortality can be minimized at an early stage of disease. Conclusion: Outcomes of this study will help clinicians to diagnose Leptospirosis at an early phase of disease and morbidity, mortality can be minimized.

Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study

“…CPK has been associated as a predictor for leptospirosis [36]. The present study investigated the significance of CPK in dengue-leptospirosis co-infected cases.…”