Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle‐aged and older Chinese population: A cross‐sectional analysis

Niu, Yixin; Zhang, Weiwei; Zhang, Hongmei; Li, Xiaoyong; Lin, Ning; Su, Weikang; Gu, Huijie; Zhu, Li; Fan, Jian‐Gao; Qin, Li; Yang, Zhen; Su, Qing

doi:10.1002/dmrr.3489

Cited by 11 publications

(13 citation statements)

References 32 publications

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“…In the general US population, liver fibrosis assessed using vibration controlled transient elastography (VCTE) is associated with CKD, specifically with a proteinuric phenotype, but not with traditional risk factors[ 25 ]. A study based on 8862 subjects reported that SCr levels were independently associated with HS [ 26 ]. Elevated SCr levels, even within the normal range, were associated with a higher risk of NAFLD [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study based on 8862 subjects reported that SCr levels were independently associated with HS [ 26 ]. Elevated SCr levels, even within the normal range, were associated with a higher risk of NAFLD [ 26 ]. Similarly, the current study demonstrates for the first time that elevated SCr levels are an independent risk factor for HS, and logistic regression analysis after adjusting for confounding factors suggests that SCr has a direct effect on HS.…”

Section: Discussionmentioning

confidence: 99%

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Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Wei

Wang

et al. 2022

BMC Gastroenterol

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Background Recent studies have shown that chronic kidney disease (CKD) prevalence is significantly higher in patients with hepatic steatosis (HS); however, it remains unclear whether HS is associated with serum creatinine (SCr). We aimed to explore the association between SCr levels and HS in a Chinese population. Methods We performed a cross-sectional study among 56,569 Chinese individuals. SCr level, other clinical and laboratory parameters, abdominal ultrasound and noninvasive fibrosis scores were extracted, and the fibrosis 4 score (FIB-4) was calculated. Results A total of 27.1% of the subjects had HS. After 1:1 propensity score matching (PSM) according to sex and age, we included 13,301 subjects with HS and 13,301 subjects without HS. SCr levels were significantly higher in the HS group than in the non-HS group [73.19 ± 15.14(μmoI/L) vs. 71.75 ± 17.49(μmoI/L), p < 0.001]. Univariate and multivariate regression analyses showed a positive association between SCr and the prevalence of HS. Stepwise regression analysis showed that the association between SCr and HS was independent of other metabolic syndrome components. The prevalence of HS increased significantly with increasing SCr levels. Metabolism-related indicators and liver enzymes were significantly higher in the HS group than in the non-HS group; furthermore, these parameters increased with increasing SCr levels. FIB-4 was significantly higher in the HS group than in the non-HS group but did not show an increasing trend with increasing SCr levels. Conclusions Our results showed an independent association between SCr level and HS risk in a Chinese population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Wei

Wang

et al. 2022

BMC Gastroenterol

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“…Current evidence showed that creatinine could be a critical index of model for end-stage liver disease (MELD) and hepatorenal syndrome (HRS) to assess liver disease severity and mortality risk (Kamath et al, 2001;Belcher et al, 2015). A cross-sectional analysis also revealed that NAFLD subjects have higher serum creatinine than those without NAFLD (Niu et al, 2021). Elevated serum uric acid-to-creatinine ratio (SUA/ Cr) may be a reliable marker for predicting NAFLD (Seo and Han, 2021).…”

Section: Discussionmentioning

confidence: 99%

Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway

Liu

Peng

et al. 2022

Front. Pharmacol.

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Serum creatinine is an endogenous biomarker to estimate glomerular filtration rate (GFR) and is commonly used to assess renal function in clinical practice. Acetaminophen (APAP), the most available analgesic and antipyretic medication, is recommended as the drug of choice for pain control in patients with renal diseases. However, an overdose of APAP can lead to severe acute liver injury, which is also the most common cause of acute liver failure in western countries. The role of creatinine in APAP-induced liver injury is unclear and should be further explored. Herein, clinical data on patients with drug-induced liver injury revealed that the creatinine concentration between 82-442 μmol/L for female and 98–442 μmol/L for male is positively correlated with alanine aminotransferase (ALT), aspartate aminotransferase (AST). While there was no correlation between creatinine and ALT and AST when creatinine concentration is over 442 μmol/L. In addition, mice were administrated with creatinine intraperitoneally for 1 week before APAP injection to investigated the pathophysiological role of creatinine in APAP-induced acute liver injury. The results showed that creatinine administration aggravated hepatic necrosis and elevated serum lactate dehydrogenase (LDH) and ALT levels in mice upon APAP injection. The mechanism study demonstrated that creatinine could increase the production of reactive oxygen activation (ROS) and the activation of c-Jun N-terminal kinase (JNK). Furthermore, the liver injury was alleviated and the difference between APAP-treated mice and APAP combined with creatinine-treated mice was blunted after using specific ROS and JNK inhibitors. Significantly, creatinine stimulation aggravates APAP-induced cell death in HepaRG cells with the same mechanism. In summary, this study proposed that creatinine is closely related with liver function of drug-induced liver injury and exacerbates APAP-induced hepatocyte death by promoting ROS production and JNK activation, thus providing new insight into the usage of APAP in patients with kidney problems.

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“…Diabetic patients have lower seropositivity rate of COVID-19 vaccination than healthy population [ 20 ]. Serum creatinine level is an useful indicator of metabolic syndrome in HS patients [ 21 ]. Renal impairment was defined as creatinine level >106 μmol/L for male and >97 μmol/L for female [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

et al. 2022

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Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects.Methods: Two hundred ninety-five subjects who received BNT162b2 or CoronaVac vaccines from five vaccination centers were categorized into moderate/severe HS (controlled attenuation parameter ≥268 dB/m on transient elastography) (n=74) or control (n=221) groups. Primary outcomes were seroconversion rates of neutralising antibody by live virus Microneutralization (vMN) assay (titer ≥10) at day21 (BNT162b2) or day28 (CoronaVac) and day56 (both). Secondary outcome was highest-tier titer response (top 25% of vMN titer; cutoff: 160 [BNT162b2] and 20 [CoronaVac]) at day 56.Results: For BNT162b2 (n=228, 77.3%), there was no statistical differences in seroconversion rates (day21: 71.7% vs. 76.6%; day56: 100% vs. 100%) or vMN geometric mean titer (GMT) (day21: 13.2 vs. 13.3; day56: 91.9 vs. 101.4) among moderate/severe HS and control groups respectively. However, lower proportion of moderate/severe HS patients had highest-tier response (day56: 5.0% vs. 15.5%; P=0.037). For CoronaVac (n=67, 22.7%), there was no statistical differences in seroconversion rates (day21: 7.1% vs. 15.1%; day56: 64.3% vs. 83.0%) or vMN GMT (5.3 vs. 5.8,) at day28. However, moderate/severe HS patients had lower vMN GMT (9.1 vs. 14.8, P=0.021) at day 56 with lower proportion having highest-tier response (21.4% vs. 52.8%, P=0.036).Conclusions: While there was no difference in seroconversion rate between moderate/severe HS and control groups after two doses of vaccine, a lower proportion of moderate/severe HS patients achieved highest-tier response for either BNT162b2 or CoronaVac.

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Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle‐aged and older Chinese population: A cross‐sectional analysis

Cited by 11 publications

References 32 publications

Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway

Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

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