Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

Khan, Md. Aminul Haque; Majumder, Md. Ishaque; Hoque, Mohammed Mainul; Fariduddin, M; Mollah, Forhadul Hoque; Iqbal, Arslan

doi:10.3329/jemc.v3i2.16129

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Mean SUA levels in our study were higher in hypothyroid group participant as compared to hyperthyoid patients. This finding is consistent with the 8,18,20,21 previous studies. that claimed higher SUA levels in primary hyperthyroidism not more than the primary hypothyroidism patients.…”

Section: Resultssupporting

confidence: 94%

Evaluation of Serum Uric Acid Levels in Patients With Primary Thyroid Dysfunction

Ayyub

Nawaz

Khan

2018

KMUJ

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Section: Resultssupporting

confidence: 94%

Evaluation of Serum Uric Acid Levels in Patients With Primary Thyroid Dysfunction

Ayyub

Nawaz

Khan

2018

KMUJ

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“…A cross sectional study done by Altahir WHM et al showed that triacylglycerol was significantly higher while cholesterol was lower among hyperthyroidism patients [30]. Also, other cross-sectional study done by Khan MAH et al indicate as there is strong association between dyslipidemia and hypothyroidism [31].…”

Section: Dyslipidemia Induce Endocrine Dysfunctionmentioning

confidence: 99%

Dyslipidemia and Endocrine Disorder

Habte¹,

Beyene²,

Feyisa³

2021

Management of Dyslipidemia

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Dyslipidemia is one of the most common risk factors for the most prevalent and fatal non-communicable diseases (NCDs); cardiovascular disease (CVD), cancer, chronic respiratory disease and diabetes and other. According to world health organization (WHO) report effective management of dyslipidemia can reduce incidence and mortality rate by NCDs up to 30%. Dyslipidemia negatively affects every vital organ; liver, kidney, heart, brain, lung and others in number of ways. In short dyslipidemia is defined as disorder of lipoprotein metabolism and it could be either hypolipoproteinemia or hyperlipoproteinemia. Endocrine disorder, poor feeding habit, physical inactivity and other factors are responsible for existence of dyslipidemia. Lipocrinology which studies about interrelationship between lipid metabolism and endocrine function in normal and abnormal condition is getting essential. Currently number of studies explain that dyslipidemia induce endocrine dysfunction and the reverse is also possible. In addition, biochemical assessment of dyslipidemia is used to monitor clinical course and progress of endocrinological diseases. Similarly, biochemical analysis of hormones helps to assess the outcome of antidyslipidemic drugs and prognoses the condition dyslipidemia. Most commonly dyslipidemia coexist with type 2 diabetes, obesity and metabolic syndrome. Abnormal distribution and accumulation fat in the body leads to deranged different hormones and factors secretion like adipokine, thereby contributing to chronic inflammation and lipotoxicity. Therefore, detailed and up-to-date review about lipid metabolism disorder and endocrine function are so essential in medicine and health science to have good service to community.

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“…Pandey et al ( 13)had been reported that the alterations in liver enzymes occurred in hypo and hyperthyroidism patients in pokhara . More over total serum protein and bilirubin levels were also affected in hypothyroid patients (14,15,16).It was found that serum creatinine and uric acid levels were increased in hypothyroid patients and could be affected due to a decrease in the levels of T4 andT3 hormones (14, 15,17,18) Aims of the study:-To investigate the physiological disorders in some liver and renal functions in females hypothyroid patients through the following items:…”

Section: Introductionmentioning

confidence: 99%

Levels of Liver Enzymes and Some Changes in Renal Functions in Iraqi Hypothyroid Patients Women

Sultan

Hameedi

2023

cbej

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The present study aimed to investigate physiological disorders in some liver and kidney functions in hypothyroid Iraqi women .The study was carried on 120 subjects in the Specialist Center of Endocrine and Diabetic diseases at Rusafa region, near AL-Kindey Hospital . That study began on 20/10/2013 to 25/1/2014 The subjects were divided into 4 groups (control, euthyroid ,subclinical and overt hypothyroid).Each group included 30 females ,their ages ranged (39.45 ±1.79) years. The results showed a significant(P˂ 0.05) increase in the level of TSH in subclinical (18.23 ± 2.34mu/l) and overt hypothyroid patients (41.37 ± 3.75 mu/l) in comparison with control (2.09 ± 0.23mu/l) and euthyroid groups (2.89 ± 0.20mu/l). The levels of T4 and T3 were within the normal limits in control (79.73 ± 2.11 nmol/L);(1.70 ± 0.07nmol/L),euthyroid (87.10 ± 2.16 nmol/L) ; (1.58 ± 0.05nmol/L) and subclinical (77.76 ± 2.31nmol/L) ; (1.52 ± 0.08 nmol/L)respectively. While overt hypothyroid group showed a significant (P˂0.05) decrease in T4 level (46.36 ± 2.32 nmol/L) with normal T3(1.30 ± 0.11 nmol/L). The changes in liver function tests in overt hypothyroid group showed a significant (P˂0.05) increase in the levels of SGOT (23.05 ± 2.67U/L),SGPT(21.89 ± 2.35 U/L) and ALP(99.98 ± 7.47 U/L) in comparison with SGOT in control (8.80 ± 0.88 U/L) , euthyroid (11.36 ± 0.85 U/L) and subclinical (11.88 ± 1.42 U/L) and SGPT in control (13.46 ± 0.75 U/L) euthyroid (10.93 ± 1.03 U/L), and subclinical (14.08 ± 1.87 U/L) and in the level of ALP in control(50.27 ± 2.65 U/L),euthyroid (65.27 ± 2.87 U/L) and subclinical(71.58 ± 4.90 U/L) respectively. Total serum protein(7.49 ± 0.16 g/dl) and bilirubin (1.23 ± 0.11 mg/dl) were increased significantly (P˂ 0.05) in overt hypothyroid patients in comparable with control (6.82 ± 0.04 gm/dl) ; (0.613 ± 0.04 mg/dl),euthyroid(6.93 ± 0.07gm/dl) ;(0.653 ±0.04 mg/dl), and subclinical (6.91 ± 0.08 gm/dl);(0.883 ± 0.08 mg/dl) respectively. Creatinine level was increased significantly (P˂0.05) in subclinical and overt hypothyroid groups (1.07 ± 0.07mg/dl);(1.26 ± 0.06mg/dl), in comparable with control and euthyroid groups (0.846 ± 0.03),(0.836 ± 0.02) respectively.The level of uric acid was increased significantly (P˂0.05) in the overt group(7.11 ± 0.11mg/dl) in comparable with control,euthyroid and subclinical (3.78 ± 0.18mg/dl),(3.66 ± 0.16mg/dl),(4.42 ± 0.28mg/dl) respectively. We concluded from this study that the overt hypothyroidism had effected the liver function tests by increasing liver enzymes SGOT,SGPT,and ALP . Also we found that total plasma protein and bilirubin levels were increased in overt hypothyroid group.The renal function test showed an increase in the levels of creatinine in subclinical and overt hypothyroid groups while uric acid increased in overt hypothyroid . Euthyroid group showed normal levels for the above studied parameters which means that the levels of these parameters returned to the normal values in treated hypothyroid group (euthyroid patients) with Levothroxine –L at a dose 50mg or 100 mg orally.

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Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

Cited by 3 publications

References 9 publications

Evaluation of Serum Uric Acid Levels in Patients With Primary Thyroid Dysfunction

Evaluation of Serum Uric Acid Levels in Patients With Primary Thyroid Dysfunction

Dyslipidemia and Endocrine Disorder

Levels of Liver Enzymes and Some Changes in Renal Functions in Iraqi Hypothyroid Patients Women

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