Serum-Creatine-Kinase Levels in Cerebral Vascular Disease

Acheson, Joan; James, D.C.O.; Hutchinson, Edward; Westhead, Ruth

doi:10.1016/s0140-6736(65)92785-6

Cited by 77 publications

(15 citation statements)

References 13 publications

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“…7, No. 1,1989 was increased in patients with cerebral infarction and cerebral hemorrhage. Their isoenzyme patterns were different from those of control subjects.…”

Section: Resultsmentioning

confidence: 93%

“…Key Words: adenylate kinase, isoenzyme, cerebral vascular disease There are many reports concerning elevated creatine phosphokinase (CPK) activity and CPK isoenzymes in acute cerebral vascular diseases (CVD) [1][2][3]. Previously, we studied CPK activity and CPK isoenzymes in the early stage of cerebral infarction, and found that the CPK levels remained within the normal limit in many cases and the band of CPK-BB was not elevated.…”

Section: Discussionmentioning

confidence: 99%

“…These results suggest that serum AK is a sensitive indicator of cerebral infarction and a useful marker to follow the course of patient recovery. Moreover, the analysis of AK isoenzymes is useful in the diagnosis of cerebral vascular diseases.Key Words: adenylate kinase, isoenzyme, cerebral vascular disease There are many reports concerning elevated creatine phosphokinase (CPK) activity and CPK isoenzymes in acute cerebral vascular diseases (CVD) [1][2][3]. Previously, we studied CPK activity and CPK isoenzymes in the early stage of cerebral infarction, and found that the CPK levels remained within the normal limit in many cases and the band of CPK-BB was not elevated.…”

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confidence: 99%

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Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

Endo

Iwata

Kuzuya

1989

J. Clin. Biochem. Nutr.

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SummarySerum adenylate kinase (AK) activity was measured in cerebral vascular diseases and the AK isoenzyme pattern was studied in the patients suffering from cerebral infarction, cerebral hemorrhage, myocardial infarction, and polymyositis. There was a significant difference in AK activity between the control subjects and patients with acute cerebral infarction. Serum AK activity showed a peak on the 2nd day to the 4th day after the stroke attack, maintained at high level for about one week, and decreased gradually thereafter. There were three isoenzymes (AK-1, AK-2, AK-3) of AK, and we found that the AK isoenzyme patterns were different in different disease. The AK isoenzyme patterns in patients with cerebral infarction and cerebral hemorrhage were different from those of control subjects. The AK-3 isoenzyme was dominant in the control subjects. The proportion of AK-1 isoenzyme was increased in cerebral infarction and cerebral hemorrhage compared with that for the control subjects, and the proportion of AK-2 isoenzyme was elevated in acute myocardial infarction and polymyositis. These results suggest that serum AK is a sensitive indicator of cerebral infarction and a useful marker to follow the course of patient recovery. Moreover, the analysis of AK isoenzymes is useful in the diagnosis of cerebral vascular diseases.Key Words: adenylate kinase, isoenzyme, cerebral vascular disease There are many reports concerning elevated creatine phosphokinase (CPK) activity and CPK isoenzymes in acute cerebral vascular diseases (CVD) [1][2][3]. Previously, we studied CPK activity and CPK isoenzymes in the early stage of cerebral infarction, and found that the CPK levels remained within the normal limit in many cases and the band of CPK-BB was not elevated. On the other hand,

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“…7, No. 1,1989 was increased in patients with cerebral infarction and cerebral hemorrhage. Their isoenzyme patterns were different from those of control subjects.…”

Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

Endo

Iwata

Kuzuya

1989

J. Clin. Biochem. Nutr.

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“…However, CPK has been shown to be elevated in some types of cerebral damage (Acheson et al, 1965;Schiavone and Kaldor, 1965;Kalbag et al, 1966;Dubo et al, 1967;Eisen and Sherwin, 1968).…”

Section: Resultsmentioning

confidence: 99%

Serum Creatine Phosphokinase Elevation following Febrile Convulsions in Infants

Salter¹,

Saunders²

1970

Ann Clin Biochem

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“…These levels may also be useful in the diagnosis of acute myocardial infarction, especially in differentiating between myocardial and pulmonary infarction (Dreyfus, Schapira, Resnais, and Scebet, 1960;Stich and Tsirimbas, 1962). Acheson, James, Hutchinson, and Westhead, (1965) (McIlwain, 1959). Herschkowitz and Cumings (1964) 'Current address.…”

mentioning

confidence: 99%

Creatine Phosphokinase in Cerebrospinal Fluid

Nathan¹

1967

JAMA

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Serum-Creatine-Kinase Levels in Cerebral Vascular Disease

Cited by 77 publications

References 13 publications

Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

Serum Creatine Phosphokinase Elevation following Febrile Convulsions in Infants

Creatine Phosphokinase in Cerebrospinal Fluid

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