Serum creatine kinase isoenzymes and macroenzymes in dogs with different neurologic diseases

Paltrinieri, Saverio; Pintore, Laura; Balducci, Federica; Giordano, Alessia; Costabile, Annaluce; Bernardini, Marco

doi:10.1111/vcp.12443

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…This corroborates literature data showing that azotemia is an uncommon finding, despite elevated frequencies of renal pathologies in CanL [58]. Creatinine is a by-product of CK, whose levels are reduced in dogs with LCan [59]; therefore, we suggest that this bias of azotemia diagnosis in advanced CanL results from sub-concentration of creatinine and might lead to kidney disease underdiagnoses. It has been stressed in the literature that the active infection by L. infantum and CanL progression relates with immune complex-mediated disease [60], which plays an important role in the pathophysiology of diverse clinical manifestations, including immune-mediated hemolytic anemia, glomerular lesions and renal failure [38,61].…”

Section: Discussionsupporting

confidence: 91%

Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy

et al. 2020

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Prediction parameters of possible outcomes of canine leishmaniasis (CanL) therapy might help with therapeutic decisions and animal health care. Here, we aimed to develop a diagnostic method with predictive value by analyzing two groups of dogs with CanL, those that exhibited a decrease in parasite load upon antiparasitic treatment (group: responders) and those that maintained high parasite load despite the treatment (group: non-responders). The parameters analyzed were parasitic load determined by q-PCR, hemogram, serum biochemistry and immune system-related gene expression signature. A mathematical model was applied to the analysis of these parameters to predict how efficient their response to therapy would be. Responder dogs restored hematological and biochemical parameters to the reference values and exhibited a Th1 cell activation profile with a linear tendency to reach mild clinical alteration stages. Differently, non-responders developed a mixed Th1/Th2 response and exhibited markers of liver and kidney injury. Erythrocyte counts and serum phosphorus were identified as predictive markers of therapeutic response at an early period of assessment of CanL. The results presented in this study are highly encouraging and may represent a new paradigm for future assistance to clinicians to interfere precociously in the therapeutic approach, with a more precise definition in the patient’s prognosis.

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Section: Discussionsupporting

confidence: 91%

Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy

et al. 2020

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“…Overexpression of miR-519b-3p suppressed the invasion and proliferation of CRC cells. Creatine kinases (CKs) are isoenzymes that catalyze the reversible transfer of phosphate groups from phosphocreatine to ADP, generating ATP and creatine (Paltrinieri et al, 2017). Different types of CKs are found in the cytosol and mitochondria of cells.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: MiR-519b-3p Inhibits the Proliferation and Invasion in Colorectal Cancer via Modulating the uMtCK/Wnt Signaling Pathway

et al. 2019

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Dysregulation of microRNAs (miRNAs) and their targeted downstream genes is involved in the carcinogenesis and progression of colorectal cancer (CRC). miR-519b-3p has been reported to play an important role in several cancers. However, its function in CRC is unclear. In this study, we detected the expression of miR-519b-3p in CRC tissues and cell lines, and determined the potential role of miR-519b-3p in cell proliferation and invasion in CRC. Also, the downstream gene of miR-519b-3p was determined. Our results showed that miR-519b-3p was notably reduced in CRC specimens and cell lines. Overexpression of miR-519b-3p inhibited the proliferation and invasion of RKO and DLD-1 cells, whereas knockdown of miR-519b-3p had the contrary effect. The ubiquitous mitochondrial creatine kinase (uMtCK) was identified as a direct target of miR-519b-3p in CRC using luciferase assay. Additionally, miR-519b-3p expression was negatively correlated with uMtCK expression in CRC specimens. Notably, the miR-519b-3p suppressed the uMtCK/Wnt signaling pathway in CRC cells, thereby suppressing CRC cell proliferation and invasion. The inhibition of uMtCK by miR-519b-3p may provide a promising option for the treatment of CRC.

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“…As the stability of coronary plaques decreases, myocardial ischemia intensifies and increases the risk of myocardial infarction, and the substances reflecting myocardial damage increase significantly. Studies have found that vaspin levels are significantly negatively correlated with myocardial injury markers such as creatine kinase isoenzymes, which in turn participate in the occurrence and progression of CHD (19). Visfatin is not only a fat factor but also an important proinflammatory factor in the body.…”

Section: Discussionmentioning

confidence: 99%

Levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), vaspin, and visfatin in elderly patients with different types of coronary heart disease

Guan¹,

Wu²,

Xiao³

et al. 2021

Ann Palliat Med

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Background: To investigate the levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), visceral adipose tissue-derived serine protease inhibitor (vaspin), and visceral fat-specific adipokine (visfatin) in elderly patients with different types of coronary heart disease (CHD).Methods: A total of 208 elderly patients with CHD admitted to our hospital were selected as the observation group, and 57 healthy volunteers who received physical examinations during the same period were selected as the healthy control group. The patients in the observation group were divided into a stable angina pectoris (SAP) group, an unstable angina pectoris (UAP) group, and an acute myocardial infarction (AMI) group according to their clinical diagnosis. The levels of serum Hcy, HDL-C, vaspin, visfatin, and coronary angiography Gensini scores were compared among the CHD subgroups and the healthy control group. Pearson linear correlation analysis was used to analyze the correlation between levels of serum Hcy, HDL-C, vaspin, and visfatin with Gensini scores in elderly patients with different types of CHD.Results: The levels of serum Hcy and visfatin in the observation group were significantly higher than those in the healthy control group (P<0.05), while the levels of serum HDL-C and vaspin were significantly lower than those in the healthy control group (P<0.05). There were statistically significant differences in the levels of serum Hcy, vaspin, and visfatin among the CHD subgroups (P<0.05). There were statistically significant differences in the Gensini scores and number of stenotic coronary arteries among the CHD subgroups (P<0.05). Pearson linear correlation analysis showed that the levels of serum Hcy, HDL-C, vaspin, and visfatin in the SAP group were not significantly correlated with Gensini scores (P>0.05). However, the levels of serum Hcy and visfatin in the UAP and AMI groups were positively correlated with Gensini scores (P<0.05), the level of serum vaspin was negatively correlated with Gensini scores (P<0.05). Conclusions:The levels of serum Hcy, vaspin, and visfatin vary according to the different types of CHD and are correlated with the degree of coronary artery stenosis. As such, these serum levels can be used as sensitive indicators for early detection and disease evaluation.

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Serum creatine kinase isoenzymes and macroenzymes in dogs with different neurologic diseases

Cited by 8 publications

References 15 publications

Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy

Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy

RETRACTED: MiR-519b-3p Inhibits the Proliferation and Invasion in Colorectal Cancer via Modulating the uMtCK/Wnt Signaling Pathway

Levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), vaspin, and visfatin in elderly patients with different types of coronary heart disease

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