Serum creatine kinase isoenzymes: A review

Nanji, Amin A.

doi:10.1002/mus.880060203

Cited by 45 publications

(15 citation statements)

References 98 publications

(4 reference statements)

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“…The CK activity in rest in serum of healthy people consists almost entirely of CK-MM; generally only traces of CK-MB and CK-BB are detected, but their levels are increased in athletes (Noakes et al 1983) and in a variety of cardiac and neurological disorders, as well as in malignant diseases (Lott and Abott 1986;Nanji 1983). After exercise 9 the CK activity in plasma changes, depending on duration and intensity as well as on training status (Berg and Haralambie 1978;Maxwell and Bloor 1981), and although most of the CK released is CK-MM, both CK-MB (5--10% of total CK), again often in athletes (Noakes et al 1983) and CK-BB have been observed (KMblock 1979).…”

Section: Discussionmentioning

confidence: 98%

Creatine kinase isoenzyme profiles after exercise in the rat: sex-linked differences in leakage of CK-MM

1988

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Changes in creatine kinase (CK) activity and CK isoenzyme profiles in plasma after exercise were studied in rats in order to establish the source of the exercise-induced rise in CK activity. Male and female rats ran on a treadmill for 2 h and blood samples, taken before and after exercise, were assayed for total CK, CK isoenzymes and aminoaspartate transaminase (AST) activity. These enzymes were also assayed in homogenates of liver and several muscles. We found that the isoenzyme composition of liver, plasma and muscle did not differ between the sexes. However, the exercise-induced CK and AST responses did differ: CK and AST increased after exercise in males (101% and 15% resp.), but much less in females (47% and 1%). Although the isoenzyme profiles in rest did not differ, significant differences were observed after running: in males CK-MM increased with 678%, but females only showed a 114% increase. In contrast, CK-BB showed a small increase that was about the same for both sexes (males 41%, females 35%). We conclude that both males and females show a small and similar increase in CK-BB activity after exercise, and that a large release of CK-MM from skeletal muscle, observed only in males, accounts for sex-linked differences reported earlier.

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Section: Discussionmentioning

confidence: 98%

Creatine kinase isoenzyme profiles after exercise in the rat: sex-linked differences in leakage of CK-MM

1988

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“…Muscle injury during spinal surgery increases the serum concentration of CK, which is routinely used for muscle injury evaluation at the early postoperative stage [10,13,17]. CK activity increased after surgery, reached a maximum on day 1, and subsequently declined to the normal value by 7 days [10].…”

Section: Discussionmentioning

confidence: 99%

Multifidus muscle changes and clinical effects of one-level posterior lumbar interbody fusion: minimally invasive procedure versus conventional open approach

et al. 2009

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We set out to determine whether a minimally invasive approach for one-level instrumented posterior lumbar interbody fusion reduced undesirable changes in the multifidus muscle, compared to a conventional open approach. We also investigated associations between muscle injury during surgery (creatinine kinase levels), clinical outcome and changes in the multifidus at followup. We studied 59 patients treated by one team of surgeons at a single institution (minimally invasive approach in 28 and conventional open approach in 31, voluntarily chosen by patients). More than 1 year postoperatively, all the patients were followed up with the visual analogue scale (VAS) and Oswestry disability index (ODI), and 16 patients from each group were evaluated using MRI. This enabled the cross-sectional area (CSA) of lean multifidus muscle, and the T2 signal intensity ratio of multifidus to psoas muscle, to be compared at the operative and adjacent levels. The minimally invasive group had less postoperative back pain (P \ 0.001) and lower postoperative ODI scores (P = 0.001). Multifidus atrophy was less in the minimally invasive group (P \ 0.001), with mean reductions in CSA of 12.2% at the operative and 8.5% at the adjacent levels, compared to 36.8% and 29.3% in the conventional open group. The increase in the multifidus:psoas T2 signal intensity ratio was similarly less marked in the minimally invasive group where values increased by 10.6% at the operative and 8.3% at the adjacent levels, compared to 34.4 and 22.7% in the conventional open group (P \ 0.001). These changes in multifidus CSA and T2 signal intensity ratio were significantly correlated with postoperative creatinine kinase levels, VAS scores and ODI scores (P \ 0.01). The minimally invasive approach caused less change in multifidus, less postoperative back pain and functional disability than conventional open approach. Muscle damage during surgery was significantly correlated with long-term multifidus muscle atrophy and fatty infiltration. Furthermore these degenerative changes of multifidus were also significantly correlated with long-term clinical outcome.

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“…Normal human serum contains MM-CK almost exclusively and it has been suggested that serum BB-CK could be used as a tumour marker (Foreback and Chu, 1981;Bais and Edwards, 1982;Grifflths, 1982;Nanji, 1983;Kanemitsu and Okigaki, 1988). Serum BB-CK increases in patients with small-cell lung carcinoma, which has higher BB-CK levels than the normal lung tissue.…”

Section: Distribution Of Ck Isoenzymes In Liver Normal Tissue and Tummentioning

confidence: 99%

“…Many reports have been published on the distribution of CK subunits and isoenzymes in tumours (for review see Foreback and Chu, 1981;Bais and Edwards, 1982;Griffiths, 1982;Nanji, 1983;Kanemitsu and Okigaki, 1988). However, most data have been obtained by immunohistochemical and immunoassay techniques.…”

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confidence: 99%

Creatine kinase activity and isoenzymes in lung, colon and liver carcinomas

Joseph

Cardesa²,

Carreras³

1997

Br J Cancer

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SummaryWe have compared the levels of creatine kinase (CK) activity and the distribution of CK isoenzymes determined by agarose gel electrophoresis in normal colon, liver and lung tissues, and in colon, liver and lung adenocarcinomas, lung squamous cell carcinomas and lung carcinoids. Colon and lung adenocarcinomas, and squamous cell carcinomas presented lower CK activity than the normal tissues and no differences were found between hepatocarcinoma and normal liver tissue. In contrast, lung carcinoids had higher CK activity than normal lung tissue. Type BB-CK was the predominant isoenzyme in normal lung, colon and liver tissues. Type MM isoenzyme was detected in normal lung and type MB-CK was found in normal colon. In most lung tumours the CK isoenzyme electrophoretic pattern did not change. However, no type BB-CK was detected in some hepatocarcinomas, type MM-CK decreased in lung carcinoids and type MB isoenzyme was not observed in colon adenocarcinomas. It is concluded that in most tumours there is a decrease in the expression of type B-and type M-CK subunits, whereas in lung carcinoid the expression of type B-CK activity increases. Thus, the increase in type BB-CK observed in the serum of patients with lung and colon adenocarcinomas is probably due mainly to enhanced enzyme release as a result of tumour cell necrosis.

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Serum creatine kinase isoenzymes: A review

Cited by 45 publications

References 98 publications

Creatine kinase isoenzyme profiles after exercise in the rat: sex-linked differences in leakage of CK-MM

Creatine kinase isoenzyme profiles after exercise in the rat: sex-linked differences in leakage of CK-MM

Multifidus muscle changes and clinical effects of one-level posterior lumbar interbody fusion: minimally invasive procedure versus conventional open approach

Creatine kinase activity and isoenzymes in lung, colon and liver carcinomas

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