Serum-Creatine-Kinase in Cases of Stroke, Head Injury, and Meningitis

Dubo, H.; Park, DorothyC.; Pennington, R. J.; Kalbag, R.M.; Walton, J.N.

doi:10.1016/s0140-6736(67)91946-0

Cited by 131 publications

(30 citation statements)

References 19 publications

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“…Both of the died patients, however, had serious complications; one had coronary insufficiency and pulmonary edema and the other had cor pul monale. As far as the patients without serious complications were concerned, our results do not contradict with the report of Dubo et al (1967). The mechanism and the reason for increase in serum CPK activity in acute CVD have been yet unknown.…”

Section: Casesupporting

confidence: 58%

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Clinical Significance of Serum Creatine Phosphokinase Activity in Cerebrovascular Diseases

Kotoku

Kawakami

Iwabuchi

et al. 1971

Tohoku J. Exp. Med.

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Section: Casesupporting

confidence: 58%

“…Of 11 cases of cerebral infarction reported by Dubo et al (1967), 4 cases, of which two died, showd no rise of serum CPK levels. They claimed that the estimation of serum CPK activity was clinically useless as laboratory examination in acute CVD.…”

Section: Casementioning

confidence: 93%

Clinical Significance of Serum Creatine Phosphokinase Activity in Cerebrovascular Diseases

Kotoku

Kawakami

Iwabuchi

et al. 1971

Tohoku J. Exp. Med.

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“…Serum enzyme estimations would be both objective and easily obtainable but have not been found to be of prognostic value. Dubo et al (1967) reported raised values of CPK in the serum of all patients studied with head injuries, as well as in 17 of 28 patients suffering from stroke or meningitis. However, no definite clinical correlations or prognostic inferences could be drawn from the serum CPK levels and isoenzyme analysis demonstrated that the CPK was mainly derived from muscle.…”

Section: Discussionmentioning

confidence: 94%

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

Maas¹

1977

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY The value of CSF enzyme estimations as indices of the extent of brain damage was studied in the experimental situation. Standard cold lesions of different severity were induced in cats. The activities of the enzymes CPK, HBDH, LDH, GOT, and ChE were studied at half hour intervals in the cerebrospinal fluid (CSF). The ventricular and cisternal fluid pressure, and the arterial blood pressure were monitored continuously. Significantly higher enzyme levels were found in the animals with more severe injuries of the brain.

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“…However, CPK has been shown to be elevated in some types of cerebral damage (Acheson et al, 1965;Schiavone and Kaldor, 1965;Kalbag et al, 1966;Dubo et al, 1967;Eisen and Sherwin, 1968).…”

Section: Resultsmentioning

confidence: 99%

“…There was, however, no measurable CPK enzyme activity present in white blood cells. Wender and Wenclewski (1961) state that there is a generalised biochemical disturbance following cerebral 'strokes' and it is therefore possible that the rise in serum CPK is a feature of whole organism response rather than a specific organ response (Dubo et al, 1967). Since in febrile convulsions there is a hypermetabolic state associated with the pyrexia, it is possible that this is responsible for the rise in CPK.…”

Section: Discussionmentioning

confidence: 99%