Serum cortisol levels in maternal venous, umbilical arterial and umbilical venous blood at delivery in the cases of fetal distress.

Kohno, Hiromasa; Furuhashi, N; Fukaya, Takao; Shinkawa, Osamu; Tachibana, Yoshinobu; Suzuki, Masakuni

doi:10.1620/tjem.144.299

Cited by 5 publications

(3 citation statements)

References 9 publications

(6 reference statements)

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“…There was a report that umbilical artery and vein cortisol level increased during fetal distress. 23 Our study demonstrated that MPI group as mild IUGR would result in better neonatal outcomes in extremely premature infants, similar to the effects of antenatal corticosteroid therapy for fetal maturation in preterm birth. So, our results suggest that extremely premature infants with MPI group as mild fetal stress would have accelerated cardiopulmonary and neurological maturation.…”

Section: Discussionsupporting

confidence: 64%

“…Therefore, the MPI group has a trend of a bottom in neonatal mortality and morbidities in extremely premature infants. We speculate that MPI indicating mild intrauterine stress might increase cortisol exposure to the fetus 23 and thus accelerate fetal neurological and cardiopulmonary maturation resulting in better neonatal outcomes in extremely premature infants.…”

Section: Discussionmentioning

confidence: 96%

“… 22 And there is a study showing that cortisol level increases during fetal stress. 23 So we speculated that the effects of fetal IUGR, as fetal stress, on neonatal mortality and morbidity would be different depending on the severity of IUGR, and that mild IUGR would show better neonatal outcomes in extremely premature infants like antenatal steroid effects.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants

et al. 2022

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Background To evaluate how intrauterine stress affects extremely premature infants in terms of intrauterine growth restriction. We hypothesized that extremely premature infants with mildly-low ponderal index (MPI) would have better neonatal outcomes. Methods We selected 2,721 subjects of 23 to 28 weeks of gestation between 2013 and 2015 from Korean Neonatal Network database. They were divided into 4 groups based on ponderal index (PI) percentile; PI ≤ 3rd as severely-low PI (SPI, n = 82), 3rd < PI ≤ 10th as MPI (n = 190), 10th < PI ≤ 90th as adequate PI (API, n = 2,179), and PI > 90th as high PI (HPI, n = 270). Results The mortality in MPI and API groups was comparable (16.3% vs. 16.9%). It was significantly lower than that in the SPI and HPI groups (30.5% and 24.9%, respectively; P = 0.001). The MPI and API groups had better neonatal morbidities compared with the SPI and/or HPI groups, while the MPI group (8.2%) showed a lower incidence of severe intraventricular hemorrhage (IVH) than the other groups (SPI, 21.3%; API, 15.0%; HPI, 19.7%, respectively; P = 0.004). The MPI group had a trend of a bottom in neonatal mortality and morbidities in extremely premature infants. Conclusion The MPI and API groups had lower mortality, massive pulmonary hemorrhage, severe bronchopulmonary dysplasia or death, pulmonary hypertension and neonatal seizure rates than the SPI and/or HPI groups, while the MPI group showed a lower incidence of severe IVH than the other groups. We speculate that the lower incidence of neonatal morbidities and mortality in the MPI group indicating mild intrauterine stress might accelerate fetal maturation resulting in better outcomes in extremely premature infants.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants

et al. 2022

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Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisolone)

Jeschke

Mylonas

Richter

et al. 2005

Arch Gynecol Obstet

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The results suggest that CRH and ACTH directly modulate the endocrine function of trophoblasts in culture by downregulating progesterone production. Prednisolone on the other hand showed a stimulating effect on progesterone production in term trophoblast cells in vitro. Because blockade of progesterone is a possible mechanism involved in initiation of labor, we may speculate that CRH and ACTH are directly involved in the auto- or paracrine regulation of this procedure.

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Placental Transfer

Atkinson

Boyd

Sibley

2006

Knobil and Neill's Physiology of Reproduction

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Serum cortisol levels in maternal venous, umbilical arterial and umbilical venous blood at delivery in the cases of fetal distress.

Cited by 5 publications

References 9 publications

Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants

Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants

Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisolone)

Placental Transfer

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