Serum Cortisol Correlates With Depression Score After Open-Heart Surgery

Schmidt-Habelmann, P.; Bullinger, Monika; Neff, Andreas; A, Büchler; Dietzfelbinger, Albrecht

doi:10.1016/s0140-6736(83)92683-1

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…There was also a significant difference between the severity of depression and mean cortisol level during postoperative days 3–5. Moreover, increased cortisol secretion is reported in depressed psychiatric patients, where cortisol levels in the cerebrospinal fluid and depression scores correlated significantly 58 …”

Section: Depressionmentioning

confidence: 96%

“…Moreover, increased cortisol secretion is reported in depressed psychiatric patients, where cortisol levels in the cerebrospinal fluid and depression scores correlated significantly. 58 Depressive symptoms can also result from an increased inflammatory activity. 32,34,35,48,59 Cytokines are hormone-like substances involved in immune-inflammatory processes and play a role in the pathophysiology of CVD.…”

Section: Autonomic Nervous System Activation Enhanced Inflammatory Re...mentioning

confidence: 99%

“…17,56 Depressed patients have increased urinary cortisol levels. 57 In 1983, Naber et al 58 found that serum cortisol and beta-endorphin levels were high in psychotic and nonpsychotic patients following surgery. Cortisol levels remained high while beta-endorphin levels returned to normal on the first postoperative day.…”

Section: Autonomic Nervous System Activation Enhanced Inflammatory Re...mentioning

confidence: 99%

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Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management

Hassanabad

Bahrami

Novick

et al. 2021

Journal of Cardiac Surgery

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Background Mental health and wellbeing continue to gain more attention as they are inextricably associated with clinical outcomes, particularly quality of life. Many medical ailments and major surgeries affect patients’ mental health, including depression and delirium. Aims The objective of this manuscript was to comprehensively review and critically examine the literature pertaining to cardiac surgery, depression, and delirium. Methods This is a narrative review article. We performed our search analysis by using the following key words: “Cardiac Surgery”, “Depression”, “Delirium”, “Clinical outcomes”, and “Mental Health”. Search analysis was done on MedLine PubMed, accessing indexed peer‐reviewed publications. Results Cardiac Surgery is a life‐altering intervention indicated to improve morbidity and mortality in patients with cardiovascular diseases. Psychiatric conditions before and after cardiac surgery worsen patient prognosis and increase mortality rate. Specifically, preoperative depression increases postoperative depression and is associated with impaired functional status, slow physical recovery, and an increased readmission rate. Discussion Although the exact pathophysiology between depression and cardiovascular disease (CVD) is unknown, several pathways have been implicated. Unmanaged depression can also lead to other psychological conditions such as delirium. Like depression, the exact association between delirium and CVD is not well understood, but believed to be multifactorial. Conclusion Herein, we provide a comprehensive review of the links between depression, delirium, and cardiovascular surgery. We critically examine the current data that pertains to the pathophysiology of these debilitating mental health issues in the context of cardiac surgery. Finally, we summarize the various treatment options available for managing depression and delirium in the cardiac surgery patient population.

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Section: Depressionmentioning

confidence: 96%

Section: Autonomic Nervous System Activation Enhanced Inflammatory Re...mentioning

confidence: 99%

Section: Autonomic Nervous System Activation Enhanced Inflammatory Re...mentioning

confidence: 99%

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Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management

Hassanabad

Bahrami

Novick

et al. 2021

Journal of Cardiac Surgery

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Gastric vagotomy blocks opioid analgesia enhancement produced by placenta ingestion

Tarapacki¹,

Thompson²,

Kristal³

1992

Physiology & Behavior

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Ingestion of amniotic fluid or placenta by rats has been shown to enhance opioid-mediated analgesia induced by morphine injection, footshock, vaginal/cervical stimulation, or late pregnancy. This enhancement by ingestion appears to be specific to the central actions of opioids. The present study was designed to examine the possibility that information traveling via the vagus nerve might be involved in mediating this effect. Rats that had undergone either selective gastric vagotomy or sham vagotomy were injected with either morphine sulfate or vehicle and fed either placenta or a meat control. Enhancement was observed in rats that had undergone sham vagotomy but not in those that had undergone gastric vagotomy. These results support an interpretation of vagal involvement in the enhancement of opioid-mediated analgesia by placenta.

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Opiate receptor sensitivity in depressed patients before and after clomipramine treatment

Jungkunz¹

1986

Journal of Affective Disorders

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Serum Cortisol Correlates With Depression Score After Open-Heart Surgery

Cited by 5 publications

References 11 publications

Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management

Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management

Gastric vagotomy blocks opioid analgesia enhancement produced by placenta ingestion

Opiate receptor sensitivity in depressed patients before and after clomipramine treatment

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