Serum Cortisol and DHEA-S Levels in Schizophrenic Patients with Different Response to Antipsychotic Therapy: Association with Psychopathology / Серумски Концентрации На Кортизол И DHEA-S Кал Пациенти Со Шизофренша Со Различен Одговор На Антипсихотичната Терапша Асоци.1Аци.1А Со Психопатологшата

Babinkostova, Zoja; Stefanovski, Branislav; Janicevic-Ivanovska, Danijela; Samardziska, Valentina; Stojanovska, Lila

doi:10.1515/prilozi-2015-0042

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…This finding is in agreement with other studies conducted previously. [19][20][21][22] Studies argue that serum cortisol level may potentially mediate the effects of lifestyle factors on psychotic symptoms and neurological deficits. According to these studies, serum cortisol may serve as biomarkers for diagnosing schizophrenia and monitoring treatment efficacy.…”

Section: Discussionmentioning

confidence: 99%

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

et al. 2021

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Background: Hypothalamic–pituitary–adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology of schizophrenia. Objective: We examined the association of serum cortisol with disease severity and improvement in schizophrenia patients in Jimma, Ethiopia. Method: A total of 34 newly diagnosed schizophrenics were included in this study. Data on demographic, behavioral, clinical state, serum cholesterol level, and antipsychotic usage were obtained at baseline and after 8 weeks. The Positive and Negative Syndrome Scale was used to assess psychotic symptoms severity. A paired sample t-test was used to compare baseline and post-treatment values. Linear regression was used to assess associations. Result: Post-treatment serum cortisol level was significantly lower than its baseline value ( p = 0.001). There was also a significant positive and negative psychotic symptoms decrease after treatment (baseline positive psychotic vs post-treatment positive psychotic symptoms: t(33) = 6.24 (95% confidence interval = 7.03,13.84, p = 0.000) and (baseline negative psychotic vs post-treatment negative psychotic symptoms: t(33) = 4.21 (95% confidence interval = 3.82, 10.99, p = 0.000). At baseline, neither positive nor negative subscore on the Positive and Negative Syndrome Scale showed an association with serum cortisol level ( B = −0.016, p = 0.794 and B = −0.032, p = 0.594). However, serum cortisol level showed strong associations with post-treatment positive sub scores and negative sub scores ( B = 0.167, p = 0.007) and ( B = 0.144, p = 0.010) on the Positive and Negative Syndrome Scale. Conclusion: We found a significant decrease in serum cortisol level after antipsychotics treatment and that was associated with improvement in psychotic symptoms in schizophrenics in Jimma, Ethiopia.

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Section: Discussionmentioning

confidence: 99%

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

et al. 2021

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Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies

et al. 2016

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Objective Several studies have reported an association between non-celiac gluten sensitivity and schizophrenia. Immune and kynurenine pathways have also been implicated in the pathophysiology of schizophrenia, and certain proinflammatory immune mediators may increase kynurenine (KYN) and reduce tryptophan (TRP) levels. Methods We thus measured serum anti-gliadin IgG, KYN and TRP in 950 patients with schizophrenia. Patients with antibody level at the 90th percentile or higher of control participants (21.9% of all patients) were classified as having elevated anti-gliadin IgG. Independent t-tests and linear regression models were used to compare TRP, KYN and KYN-TRP ratio (indicator of TRP metabolism) between patients with, and those without elevated anti-gliadin IgG. The correlation between anti-gliadin IgG and TRP, KYN and the ratio was also evaluated in the patients. Results KYN and KYN-TRP ratio were higher in patients with elevated anti-gliadin IgG (geometric mean 2.65 mmol/l, SD = 0.25 vs. 2.25mmol/l, SD = 0.23, p < 0.001 and 0.05, SD = 0.26 vs. 0.04, SD = 0.25, p = 0.001 respectively), findings robust to adjustment for potential demographic and clinical confounders. Anti-gliadin IgG correlated with KYN and KYN-TRP ratio in unadjusted analysis (r = 0.12, p < 0.001; r = 0.11, p = 0.002). TRP did not differ between the 2 groups and did not correlate with anti-gliadin IgG. Conclusions Our results connect non-celiac gluten sensitivity with the kynurenine pathway of tryptophan metabolism in psychotic illness and hint towards potential individualized treatment targets.

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Cited by 2 publications

References 28 publications

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies

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