Serum corin is associated with the risk of chronic heart failure

Abstract

It has been well documented that corin is a critical protease involved in the regulation of blood pressure and cardiac function. We performed a case-control study to determine whether serum corin is associated with the risk of chronic heart failure (CHF). We included 484 consecutive CHF patients and 484 control subjects to investigate the potential relationship between serum corin and CHF using logistic regression analysis. Compared with healthy controls, the CHF patients were more likely to have histories of hypertension and diabetes, and had higher levels of N-terminal pro-brain natriuretic peptide and lower levels of corin. The odds ratios of ischemic and non-ischemic HF were significantly reduced with the growing levels of serum corin after multivariate adjustment. Moreover, the decrease in serum corin levels seemed to be associated with the severity of CHF. In conclusion, our study suggested that serum corin levels were reduced in CHF patients and inversely correlated with the incidence of ischemic and non-ischemic HF.

Edema formation in congestive heart failure and the underlying mechanisms

“…Additionally, corin is also found in the blood system in its circulating forms. Previous studies demonstrated the decreased concentration of soluble circulating corin in patients with HF and acute myocardial infarction, compared to healthy individuals (183)(184)(185)(186)(187)(188)(189)(190)(191). Noteworthy, clinical studies demonstrated that decompensated heart failure, assessed by edema and elevated plasma ANP/BNP levels, is associated with reduced corin levels and decreased cleavage of proANP/proBNP peptides (179,(192)(193)(194)(195).…”

Evaluation of CORIN in patients with heart failure: A systematic review and meta-analysis

“…[16][17][18] Clinical and translational studies conducted over the past decade strongly support the pro-ANP convertase CORIN as a biomarker and effector of HF and myocardial infarction. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] CORIN is proteolytically cleaved from the cell membrane and released into circulation as soluble fragments of different sizes. Heart failure and acute myocardial infarction affect cardiac corin expression and shedding by different mechanisms.…”

“…24,30,31 Plasma and cardiac CORIN levels decreased in patients with HF and animal models of HF. 14,16,21,24,29,32 So far, several newly published randomized controlled trials have compared the evaluation of CORIN between heart failure group and control group. In order to fully evaluate the role of CORIN, relevant articles are included to evaluate CORIN levels from a different direction.…”

“…16–18 Clinical and translational studies conducted over the past decade strongly support the pro-ANP convertase CORIN as a biomarker and effector of HF and myocardial infarction. 16–29…”

“…24,30,31 Plasma and cardiac CORIN levels decreased in patients with HF and animal models of HF. 14,16,21,24,29,32…”