Serum copper, zinc and high-sensitivity C-reactive protein in short and long sleep duration in ageing men

Luojus, Maria K.; Lehto, Soili M.; Tolmunen, Tommi; Elomaa, Antti-Pekka; Kauhanen, Jussi

doi:10.1016/j.jtemb.2015.07.008

Cited by 19 publications

(5 citation statements)

References 36 publications

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“…Consistent with the present study results, Luojus et al reported a significant and direct correlation between serum zinc levels and participants' sleep hours (31). Also, the results of another study showed that administration of zinc-containing yeast extract to mice increased the total amount of nonrapid eye movement sleep and decreased the locomotor activity (32).…”

Section: Discussionsupporting

confidence: 91%

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

Afzali¹,

Mohandes²,

Goli³

et al. 2022

Acta fac medic Naissensis

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Introduction/Aim: The use of macronutrient and micronutrient foods is associated with the duration of sleep. This study aimed to determine the effect of zinc supplements on the sleep quality of older adults. Methods: The current parallel randomized clinical trial study was performed using a convenience sampling method. One hundred and fifty older adults who met the inclusion criteria were assigned to intervention and control group. The participants in the intervention group received a daily dose of 30 mg zinc supplementation pill for 70 days and the control group did not receive any supplement. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). Serum zinc level in both groups was measured through the auto-analysis method. The questionnaire was completed and the serum level of zinc was measured twice, before the intervention and 70 days after the intervention. Results: Both groups were homogeneous in terms of demographic variables, sleep quality, and serum zinc level before the intervention. Of all, 73.3% of older adults in the intervention group and 74.7% of older adults in the control group had poor sleep quality. Sleep quality in the intervention group, as compared with the control group, significantly improved after the intervention. Furthermore, serum zinc levels in older adults in the intervention group, as compared with the control group, significantly increased after the intervention. Conclusion: Based on the results of this study, it is recommended to utilize zinc supplementation as a new therapeutic approach for improving sleep quality in older adults.

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Section: Discussionsupporting

confidence: 91%

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

Afzali¹,

Mohandes²,

Goli³

et al. 2022

Acta fac medic Naissensis

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“…Cu levels showed mixed effects in prior research. Whereas researchers reported a negative relationship between hair Cu levels and sleep duration in 126 women aged 21–72 years ( 41 ) , a study of 2570 men aged 42–60 years showed highest average levels of serum Cu in the group with the longest sleep duration ( 43 ) .…”

Section: Resultsmentioning

confidence: 99%

“…Confounders that were typically adjusted for included age, sex, education, family income, BMI, energy intake, smoking status and race/ethnicity. There are only four studies involving covariates of depressive symptoms or antidepressant use ( 20 , 43 , 52 , 53 ) . Future research should take into account important covariates, such as a medical history of psychiatric disorder or medication usage known to affect micronutrient absorption or sleep, to uncover the nature of the associations.…”

Section: Discussionmentioning

confidence: 99%

The relationship between micronutrient status and sleep patterns: a systematic review

Grandner

Liu

2016

Public Health Nutr.

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Objective To review articles on the relationship of dietary and circulating micronutrients with sleep patterns, and to identify issues surrounding implications for future research and public health practice. Design A systematic review was conducted. PubMed, Embase and Scopus were searched through January 2016. Setting Both experimental and observational studies were included. However, studies that focused on secondary sleep impairment due to comorbidities were excluded. Subjects Individuals in different age groups, from infants to older adults. Results A total of twenty-six articles were selected. In the articles reviewed, researchers generally supported a potential role of micronutrients, particularly Fe and Mg, in the development of sleep stages among infants and in reversing age-related alterations in sleep architecture in older adults. Micronutrient status has also been linked to sleep duration, with sleep duration positively associated with Fe, Zn and Mg levels, and negatively associated with Cu, K and vitamin B12 levels. The mechanisms underlying these relationships include the impact of micronutrients on excitatory/inhibitory neurotransmitters and the expression of circadian genes. Conclusions Although the number of studies on the relationship between micronutrient status and sleep remains low, evidence has emerged that suggests a link between dietary/circulating micronutrients and sleep. Future research is needed to investigate the dose-dependent as well as the longitudinal relationships between micronutrient levels and human sleep across populations, test the interactions among micronutrients on sleep outcomes, and ultimately examine the clinical relevance of micronutrients on sleep health.

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“…On the contrary, some studies have suggested that sleep duration is associated with serum Zn level. Luojus, Lehto, Tolmunen, Elomaa, and Kauhanen (2015) reported that the level of serum Zn was low in men who sleep less than 6 hours per night. In another study, Song, Kim, and Jung (2012) found a significant association between serum Zn level and sleep duration in adult women.…”

mentioning

confidence: 99%

The Effect of Zinc Supplementation on Sleep Quality of ICU Nurses: A Double Blinded Randomized Controlled Trial

Baradari

Alipour

Mahdavi

et al. 2017

Workplace Health Saf

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This study examined the effect of zinc supplementation on the sleep quality (SQ) of intensive care unit (ICU) nurses. In a double-blind, randomized controlled trial, 54 ICU nurses were randomly assigned to the intervention group ( n = 27) that received 220 mg zinc sulfate capsules every 72 hours for 1 month and the control group ( n = 26) that received placebo. Sleep quality of ICU nurses was measured by calculating the total quality sleep score using the Pittsburgh Sleep Quality Index (PSQI). The serum zinc level was a secondary outcome. All measurements were calculated at both baseline and 1 month after intervention. The total PSQI, subjective SQ, and sleep latency scores for the intervention group were significantly lower than the control group, which means that the SQ of ICU nurses in the intervention group improved from baseline. The serum zinc level of the intervention group at the end of the study was significantly higher than the control group, which means that zinc supplementation improved participants' serum zinc level. Based on these findings, the researcher suggested that zinc supplementation could be associated with better SQ, subjective SQ, and sleep latency in this group of workers.

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Serum copper, zinc and high-sensitivity C-reactive protein in short and long sleep duration in ageing men

Cited by 19 publications

References 36 publications

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

The relationship between micronutrient status and sleep patterns: a systematic review

The Effect of Zinc Supplementation on Sleep Quality of ICU Nurses: A Double Blinded Randomized Controlled Trial

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