Serum Copper Levels in Elderly Patients with Femoral-neck Fractures

Conlan, D.; Korula, Roy John; Tallentire, D.

doi:10.1093/ageing/19.3.212

Cited by 56 publications

(30 citation statements)

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“…In humans, there is some evidence for a role for Cu de®ciency in age-related osteoporosis. For example, Conlan et al (1990) found that serum Cu levels of 46 elderly patients with fractures of the femoral neck were signi®cantly lower than those of a group of controls matched for age and sex. A signi®cant positive correlation between serum Cu concentration and bone mineral density (BMD) at the lumbar spine has been reported in a cross-sectional study in postmenopausal women (Howard et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status

et al. 2001

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Objective: To investigate the effects of increasing Cu intakes, above the usual dietary intake, on biomarkers of bone metabolism in healthy young adult females (aged 21 ± 28 y) over a 4 week period. Design: A double-blind, placebo-controlled randomised repeat crossover Cu supplementation trial. Setting: The study was conducted at the Royal Veterinary and Agricultural University (RVAU), Copenhagen, Denmark. Subjects: Sixteen healthy young adult females aged 20 ± 28 y were recruited from among students at the RVAU. Intervention: During the 4 week intervention periods in this randomised, crossover trial (3Â4 weeks with a minimum 3 week wash-out period), each subject received, in addition to their usual diet, either 3 or 6 mg elemental Cuaday as CuSO 4 or a matching placebo. On the last 3 days of each dietary period 24 h urines were collected. In addition, blood was collected on the last day of each dietary period. Results: Serum Cu and erythrocyte superoxide dismutase (but not caeruloplasmin protein concentration or activity (putative indices of Cu status)) were signi®cantly increased (P`0.05) after daily Cu supplementation with 3 and 6 mgaday for 4 weeks. Serum osteocalcin (biomarker of bone formation), urinary creatinine (Cr) concentration, urinary pyridinoline (Pyr)aCr or deoxypyridinoline (Dpyr)aCr excretion, or daily urinary Pyr or Dpyr excretion (biomarkers of bone resorption) were unaffected by Cu supplementation. Conclusion: Copper supplementation of the usual diet in healthy young adult females, while apparently improving Cu status, had no effect on biochemical markers of bone formation or bone resorption over 4 week periods. Sponsorship: Funding from the European Commission.

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Section: Introductionmentioning

confidence: 99%

No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status

et al. 2001

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“…Hence, the demonstrated physiological rise of ceruloplasmin in arthritis is suggested to represent a protective response. Consistent with this, a lack of rise of ceruloplasmin may increase the risk of chronic disease, as seen in Cu-deficient animals with adjuvant arthritis (Conlan et al 1990). There is some evidence for a role of Cu deficiency in age-related osteroporosis.…”

Section: Discussionmentioning

confidence: 73%

“…Serum copper levels of 46 elderly patients with fractures of the femoral neck were reported to be significantly lower than those of a group of controls matched for age and sex (Jorde et al 2010). A significant positive correlation between serum Cu concentration and bone mineral density at the lumbar spine has been reported in a cross-sectional study in postmenopausal women (Conlan et al 1990). EatonEvans et al (1996) have recently shown that Cu supplementation (3 mg/day for 2 days) reduced the rate of loss of bone mineral density at the lumbar spine in 46to 56year-old women.…”

Section: Discussionmentioning

confidence: 89%

Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers

Afridi

Talpur

Kazi

et al. 2015

Environ Monit Assess

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Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining the health. A significant flux of heavy metals, among other toxins, reaches the lungs through smoking. In the present study, the relationship between toxic element (TE) exposure via cigarette smoking and rheumatoid arthritis incidence in population living in Dublin, Ireland, is investigated. The trace {zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se)} and toxic elements arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) were determined in biological (scalp hair and blood) samples of patients diagnosed with rheumatoid arthritis, who are smokers living in Dublin, Ireland. These results were compared with age and sex-matched healthy, nonsmoker controls. The different brands of cigarette (filler tobacco, filter, and ash) consumed by the studied population were also analyzed for As, Cd, Hg, and Pb. The concentrations of trace and TEs in biological samples and different components of cigarette were measured by inductively coupled plasma mass spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials. The recovery of all the studied elements was found to be in the range of 96.4-99.8 % in certified reference materials. The filler tobacco of different branded cigarettes contains Hg, As, Cd, and Pb concentrations in the ranges of 9.55-12.4 ng, 0.432-0.727 μg, 1.70-2.12 μg, and 0.378-1.16 μg/cigarette, respectively. The results of this study showed that the mean values of As, Cd, Hg, and Pb were significantly higher in scalp hair and blood samples of rheumatoid arthritis patients as compare to healthy controls, while Zn, Cu, Mn, and Se concentrations were found to be lower in rheumatoid arthritis patients, the difference was significant in the case of smoker patients (p<0.001). The levels of four toxic elements were 2-3-folds higher in scalp hair and blood samples of nonrheumatoid arthritis smoker subjects as compared to nonsmoker controls. The high exposure of toxic metals as a result of cigarette smoking may be synergistic with risk factors associated with rheumatoid arthritis.

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“…Hence the demonstrated physiological rise of ceruloplasmin in arthritis is suggested to repre-sent a protective response. Consistent with this, a lack of rise of ceruloplasmin may increase the risk of chronic disease, as seen in Cu-deficient animals with adjuvant arthritis (Conlan et al, 1990). There is some evidence for a role of Cu deficiency in age-related osteoporosis.…”

Section: -Discussionmentioning

confidence: 74%

“…Serum copper levels of 46 elderly patients with fractures of the femoral neck were reported to be significantly lower than those of a group of controls matched for age and sex (Jorde et al, 2010). A significant positive correlation between serum Cu concentration and bone mineral density at the lumbar spine has been reported in a cross sectional study in postmenopausal women (Conlan et al, 1990). Eaton- Evans et al(1996) have recently shown that Cu supplementation (3 mg/day for 2 days) reduced the rate of loss of bone mineral density at the lumbar spine in 46-to 56-year-old women.…”

Section: -Discussionmentioning

confidence: 89%

Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects

Afridi

Kazi

Brabazon

et al. 2011

Science of The Total Environment

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The incidence of rheumatoid arthritis (RA) has been increased among people who possess habit of tobacco smoking. In the present study, zinc (Zn), copper (Cu), manganese (Mn), lead (Pb) and cadmium (Cd) were determined in scalp hair samples of smokers and nonsmokers RA patients, residents of Dublin, Ireland. For comparison purposes scalp hair samples of age and sex matched healthy smokers and nonsmokers were also analyzed. The concentrations of understudied elements were measured by inductive coupled plasma atomic emission spectrophotometer, prior to microwave assisted acid digestion. The validity and accuracy of methodology was checked using certified reference material (NCS ZC 81002b) and by the conventional wet acid digestion method on the same certified reference material and on real samples. The mean hair Zn, Cu and Mn contents were significantly lower in smokers and nonsmokers RA patients as compared to healthy individuals (p = 0.01-0.001). Whereas the concentrations of Cd and Pb were significantly higher in scalp hair samples of RA patients of both group (p <0.001). The referent smokers have high level of Cd and Pb in their scalp hair samples as compared to those had not smoking tobacco (p <0.01). The ratio of Cd and Pb to Zn, Cu and Mn in scalp hair samples was also calculated. The Cd/Zn ratio was higher in smoker RA patients with re-lated to nonsmoker RA and referents. This study is compelling evidence in support of positive associations between toxic elements, cigarette smoking, deficiency of essential trace elements and risk of arthritis.

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Serum Copper Levels in Elderly Patients with Femoral-neck Fractures

Cited by 56 publications

References 0 publications

No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status

No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status

Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers

Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects

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