Serum copper in Alzheimer’s disease and vascular dementia

Agarwal, Rachna; Kushwaha, Suman; Tripathi, Chandra Bhushan; Singh, Neeraj; Chhillar, Neelam

doi:10.1007/s12291-008-0081-8

Cited by 29 publications

(13 citation statements)

References 23 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NINCDS-ADRDA criteria [44] and a Mini-Mental State Examination (MMSE) [45] score of 25 or less (range [16][17][18][19][20][21][22][23][24] were used for AD diagnosis.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals

Squitti

Ghidoni

Scrascia

et al. 2011

JAD

View full text Add to dashboard Cite

In patients affected by Alzheimer's disease (AD), serum copper not bound to ceruloplasmin ('free' copper) appears elevated, slightly but significantly enough to distinguish AD patients from healthy elderly subjects. In this paper we tested the hypothesis that this is also the case for individuals affected by mild cognitive impairment (MCI). A sample of 83 MCI subjects were compared with 100 elderly control subjects in terms of levels of serum copper, free copper, ceruloplasmin, apolipoprotein E4 genotype (APOE4), iron, transferrin, and total antioxidant capacity (TRAP). The groups were also compared in terms of demographic and cardiovascular risk factors. The comparison with an additional group of 105 mild to moderate AD patients was also evaluated. The possible effects of copper dysfunction on cognitive decline were evaluated by multinomial logistic regression analysis. A linear regression model was applied to define the role of metals and antioxidant dysfunction in explaining Mini-Mental Status Examination (MMSE) variations. APOE4 and free copper differentiated the MCI group from the healthy control group. The probability of acquiring MCI increased by about 24% for each free copper unit (μmol/L) increment. APOE4 and free copper differentiated the MCI group also from the AD group. APOE4 and free copper appeared associated to MMSE worsening, as did age and gender. These results suggest that free copper can help in discriminating MCI subjects from healthy controls, but not on an individual basis.

show abstract

“…NINCDS-ADRDA criteria [44] and a Mini-Mental State Examination (MMSE) [45] score of 25 or less (range [16][17][18][19][20][21][22][23][24] were used for AD diagnosis.…”

Section: Methodsmentioning

confidence: 99%

“…Some studies of AD patients versus healthy controls reported an increase of circulating copper in AD [12][13][14][15][16][17][18]. Other studies have reported no variation [19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals

Squitti

Ghidoni

Scrascia

et al. 2011

JAD

View full text Add to dashboard Cite

show abstract

“…Decreased concentration Unchanged concentration Cu Hippocampus, entorhinal cortex, frontal cortex, putamen (102,119) and senile plaques (121) Hippocampus, amygdala (99) , basal ganglia (116) and cortex (117) Hippocampus, cerebellum, cortex (98,99,118) , amygdala (99,118) and hippocampus (114) Fe Senile plaques (121) , amygdala, piriform cortex, olfactory system (109) , hippocampus/amygdala (99,124) , frontal cortex (102) , grey motor cortex (103,124) , temporal cortex (105) , hippocampus (106) , frontal/parietal/temporal lobe (107) , putamen/thalamus/globus pallidus/area occipitalis (108) and cortex (116) Basal ganglia (116) and hippocampus (114,115) Pituitary gland (125) CSF (61) levels of Cu in patients with AD or mild cognitive impairment (93) compared with healthy controls. In these studies, total Cu (78,80,94,139 -141) , ceruloplasmin (140,141) as well as 'free' Cu (ceruloplasmin non-bound Cu) (78,93,140,142,143) have been found at increased rates. The free Cu fraction correlated positively with CSF biomarkers of AD including Ab and hyperphosphorylated t (143) and inversely with MMSE (143) .…”

Section: Increased Concentrationmentioning

confidence: 96%

Copper and iron in Alzheimer's disease: a systematic review and its dietary implications

Loef

Walach

2011

Br J Nutr

View full text Add to dashboard Cite

Fe and Cu could represent dietary risk factors for Alzheimer's disease (AD), which has become a global health concern. To establish the relationship between diets high in Cu and Fe and cognitive decline or AD, we have conducted a systematic review of the literature (up to January 2011). We identified two meta-analyses, two systematic reviews, eleven placebo-controlled trials, five observational studies, forty-five case -control studies, thirty autopsy and five uncontrolled studies, and one case report. There were eleven interventional trials that tried to either supplement or deplete Fe and Cu, but none of them provided clear evidence of a beneficial effect on cognitive performance in patients with AD. The prospective studies revealed an association between a diet simultaneously high in SFA and Cu and cognitive decline. Case -control and autopsy studies showed elevated Fe levels in the brains of AD patients, whereas the evidence was less consistent for Cu. In most of the studies, Cu concentrations were unchanged in the cerebrospinal fluid and the brain but increased in the serum. In conclusion, the existing data suggest that diets excessive in Fe or Cu, together with a high intake of SFA, should be avoided in the elderly who are not at risk of anaemia. Basic studies and, building on this, clinical investigations are needed to further elucidate in which dietary patterns and in which patient groups an Fe-and Cu-rich diet might foster the risk of developing AD.

show abstract

“…Non-ceruloplasmin bound copper (NCC) is slightly bound to peptides, albumin, amino acids and, due to its low molecular weight, is able to cross the brainblood barrier [32] so that the increase of plasma copper levels lowers cognitive function [5]. It has been found that high dietary intake of copper may be associated with accelerated cognitive decline [33] as well as the plasma copper levels in Alzheimer's patients is higher than that of healthy people [34] and copper-chelating agents slowed cognitive decline in Alzheimer's patients [35]. It is thought that a brain damage may occur due to the interaction of copper with copper with amyloid-β (Aβ) peptide which can cause a b amyloid (b-amyloid) conversion to rouge form, generating H 2 O 2 and impacts on cognition [5,32] but in this study there was no significant changes in copper levels in patients, as though there is no correlation between serum copper level and Alzheimer's patients in Iran [36].…”

Section: Discussionmentioning

confidence: 99%

A Research on the Level of Zinc and Copper in the Hair of Students with Lower IQ

Meghrazi

Sabet²,

Kheradmand

et al. 2017

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: The measurement of trace elements in human body has proved to be of great use in the evaluation of human health and the diagnosis of various diseases. No light, however, has been shed on these elements where they concern the human intelligence. Objectives:The goal is to make a comparison between the students with a lower IQ and those having an ordinary IQ in terms of the amount of zinc and copper as two trace elements. Methods: This is a case-control study and the subjects as the patients were chosen from mentally retarded students having no particular diseases. The sample size for the patient and control was 30 for each. The hair samples of the experimental group and the ordinary students (the control group) were digested with concentrated HNO3 after being washed with water and acetone. After being digested, the values of zinc and copper in the samples were measured with atomic absorption spectroscopy. The obtained data were analyzed using SPSS-15 via two independent sample tests of significance tests.

show abstract

Serum copper in Alzheimer’s disease and vascular dementia

Abstract: Alzheimer's disease is the most common form of dementia in the elderly

Cited by 29 publications

References 23 publications

Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals

Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals

Copper and iron in Alzheimer's disease: a systematic review and its dietary implications

A Research on the Level of Zinc and Copper in the Hair of Students with Lower IQ

Contact Info

Product

Resources

About