Serum copper concentration significantly less in abnormal pregnancies.

Buamah, Paul K.; Russell, M.; Milford-Ward, A; Taylor, P; Roberts, David G.

doi:10.1093/clinchem/30.10.1676

Cited by 21 publications

(11 citation statements)

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“…The results presented in the discussion confirm the U-shaped relationship between the concentration of Cu in the blood of pregnant women and the health effects related to OS, representing the left [ 86 , 87 , 88 , 89 , 90 , 91 , 99 , 100 , 101 ] or the right [ 85 , 92 , 95 , 96 , 101 ] arm of the curve. Taking into account that the results obtained in the present study concerned a group of women characterized mostly by insufficient Cu concentrations (66.7%), with a median value of 78.02 (IQR—44.00–123.20) μg/dL, the demonstrated correlation seems to support the U-shaped nature of the curve of the discussed relationship, representing its left arm, and suggesting the concentration of 3′NT in umbilical cord blood may decrease as the concentration of Cu in maternal blood approached the optimal values.…”

Section: Discussionsupporting

confidence: 74%

“…A lower blood Cu concentration was also found by Biswas et al (2016) in women with gestational hypertension compared to that in healthy pregnant women [ 89 ]. Neural tube defects, including foetal anencephaly, also appear to be associated with both maternal Cu deficiency [ 90 , 91 ] and its excess [ 92 ], and OS was suggested as one of the probable mechanisms [ 55 , 93 , 94 ]. Moreover, Wilson et al (2018) showed that pregnant women with higher blood Cu levels (3rd tertile) had a significantly higher risk of gestational complications (pre-eclampsia, gestational diabetes, premature birth and/or SGA) compared to pregnant women whose Cu blood concentration was within the 1st and 2nd tertiles.…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

et al. 2021

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Oxidative stress (OS) in the foetal and neonatal periods leads to many disorders in newborns and in later life. The nutritional status of pregnant women is considered to be one of the key factors that triggers OS. We investigated the relationship between the concentration of selected mineral elements in the blood of pregnant women and the concentration of 3′nitrotyrosine (3′NT) as a marker of OS in the umbilical cord blood of newborns. The study group consisted of 57 pregnant women and their newborn children. The concentrations of magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn) and copper (Cu) in maternal serum (MS) were measured by the flame atomic absorption/emission spectrometry (FAAS/FAES) method. The concentration of 3′NT in umbilical cord serum (UCS) of newborns was determined by the ELISA method. A positive correlation between MS Fe and UCS 3′NT in male newborns was shown (rho = 0.392, p = 0.053). Significantly higher UCS 3′NT was demonstrated in newborns, especially males, whose mothers were characterized by MS Fe higher than 400 μg/dL compared to those of mothers with MS Fe up to 300 μg/dL (p < 0.01). Moreover, a negative correlation between the MS Cu and UCS 3′NT in male newborns was observed (rho = −0.509, p = 0.008). Results of the study showed the need to develop strategies to optimize the nutritional status of pregnant women. Implementation of these strategies could contribute to reducing the risk of pre- and neonatal OS and its adverse health effects in the offspring.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

et al. 2021

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“…major defect is quite low, for example, 1 in 8,000 for anencephaly. It is of interest to note that Bumah et al 48 have reported that low serum copper concentrations in pregnant women during midgestation is a risk factor for anencephaly. The women in their report were, of course, not Wilson' s disease patients, but the concordance with our one case of microcephaly bears watching.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy

et al. 2000

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Therapy of Wilson's disease continues to evolve. In 1997, zinc acetate was added to the list of drugs approved by the Food and Drug Administration, which includes penicillamine and trientine. The mechanism of zinc's anticopper action is unique. It induces intestinal cell metallothionein, which binds copper and prevents its transfer into blood. As intestinal cells die and slough, the contained copper is eliminated in the stool. Thus, zinc prevents the intestinal absorption of copper. It is universally agreed that pregnant Wilson's disease patients should remain on anticopper therapy during pregnancy. There are numerous reports of such patients stopping penicillamine therapy to protect their fetus from teratogenicity, only to undergo serious deterioration and even death from renewed copper toxicity. Penicillamine and trientine have teratogenic effects in animals, and penicillamine has known teratogenic effects in humans. In this report we discuss the results of 26 pregnancies in 19 women who were on zinc therapy throughout their pregnancy. The evidence is good that zinc protects the health of the mother during pregnancy. Fetal outcomes were generally quite good, although one baby had a surgically correctable heart defect and one had microcephaly. (HEPATOLOGY 2000;31:364-370.)

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“…One study of over 800 problem pregnancies found that serum copper levels were much lower throughout pregnancy compared to healthy pregnant controls and especially lower in those involving spontaneous abortion of the fetus [32]. Similarly, other studies have found lower copper in women with spontaneous abortion, threatened abortion, missed abortion and blighted ovum [31,33], and in anencephalic pregnancies [33]. Another study found that in drinking water, copper was the mineral most strongly associated with central nervous system (CNS) malformations [34].…”

Section: Researchmentioning

confidence: 98%

“…In general, Tables 1 and 2 indicate that many maternal and infant health complications are associated with one or more minerals. [3,7,8,10,11,[14][15][16][17]20,24,[26][27][28][30][31][32][33][35][36][37]39,40,49,[94][95][96][97]100,[102][103][104][105]116,124,[126][127][128]130,132,141].…”

Section: Associations Between Health Outcomes and Mineral Statusmentioning

confidence: 99%

Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals

et al. 2021

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The levels of many essential minerals decrease during pregnancy if un-supplemented, including calcium, iron, magnesium, selenium, zinc, and possibly chromium and iodine. Sub-optimal intake of minerals from preconception through pregnancy increases the risk of many pregnancy complications and infant health problems. In the U.S., dietary intake of minerals is often below the Recommended Dietary Allowance (RDA), especially for iodine and magnesium, and 28% of women develop iron deficiency anemia during their third trimester. The goal of this paper is to propose evidence-based recommendations for the optimal level of prenatal supplementation for each mineral for most women in the United States. Overall, the evidence suggests that optimal mineral supplementation can significantly reduce a wide range of pregnancy complications (including anemia, gestational hypertension, gestational diabetes, hyperthyroidism, miscarriage, and pre-eclampsia) and infant health problems (including anemia, asthma/wheeze, autism, cerebral palsy, hypothyroidism, intellectual disability, low birth weight, neural tube defects, preterm birth, rickets, and wheeze). An evaluation of 180 commercial prenatal supplements found that they varied widely in mineral content, often contained only a subset of essential minerals, and the levels were often below our recommendations. Therefore, there is a need to establish recommendations on the optimal level of mineral supplementation during pregnancy.

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Serum copper concentration significantly less in abnormal pregnancies.

Abstract: We estimated copper concentration in maternal serum during 244 normal and 15 abnormal pregnancies. Values were lower in the abnormal pregnancies than in the normal ones, and did not vary with gestational age between 15 to 18 weeks in normal pregnancies.

Cited by 21 publications

References 0 publications

Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy

Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals

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