Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D

Seven, Gülseren; Karatayli, SC; Sk, Köse; Yakut, Mustafa; Kabaçam, Gökhan; Törüner, Murat; Ao, Heper; Voelker, Michael; Erden, Esra; Bozdayı, A. Mithat; Uzunalımoǧlu, Özden; Bozkaya, Hakan; Yurdaydın, Cihan; Schuppan, Detlef

doi:10.4318/tjg.2011.0217

Cited by 17 publications

(15 citation statements)

References 60 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The AUROC of serum TIMP-1 was 0.92 for significant liver fibrosis (≥stage 2), with sensitivity 89.4% and specificity 83.6% at a cut-off value ≥174.5 ng/mL. Seven et al (87) concluded that TIMP-1 and HA were powerful predictors of fibrosis (odds ratio's of 8.65 and 8.38) in 109 patients with HBV and hepatitis D (HDV) infection. Another small study found that TIMP-1 mRNA levels in combination with platelet-derived growth factor-BB (PDGF-BB) gave sensitivity and specificity values for liver fibrosis of 97.4% and 95%, respectively (88).…”

Section: Direct Serum Markers Of Fibrosismentioning

confidence: 99%

Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection

Parikh¹,

Ryan²,

Tsochatzis³

2017

Ann. Transl. Med.

View full text Add to dashboard Cite

Chronic hepatitis B virus (HBV) infection is a major cause of liver morbidity and mortality worldwide.While a proportion of the 250 million individuals chronically infected with HBV will not come to significant harm or require therapy, many others risk developing complications of the end-stage liver disease such as decompensated cirrhosis and hepatocellular carcinoma (HCC), without intervention. Due to the complex natural history of HBV infection, patients require an expert assessment to interpret biochemistry, viral serology and appropriately stage the disease, and to initiate monitoring and/or therapy where indicated. The detection and quantification of liver fibrosis is a key factor for disease management and prognostication for an individual with HBV. The reliance on invasive liver biopsy to stage disease is diminishing with the advent of robust non-invasive blood-and imagingbased algorithms which can reliably stage disease in many cases. These tests are now incorporated into International guidelines for HBV management and relied upon daily to inform clinical judgement. Both blood-and imagingbased approaches have advantages over liver biopsy, including minimal risks, lower cost, better patient acceptance and speed of results, while disadvantages include lower diagnostic accuracy in intermediate disease stages and variability with co-existing hepatic inflammation or steatosis. This review outlines the methods of fibrosis assessment in chronic HBV infection and focuses on the most commonly used blood-and imaging-based noninvasive tests, reviewing their diagnostic performance and applicability to patient care.

show abstract

Section: Direct Serum Markers Of Fibrosismentioning

confidence: 99%

Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection

Parikh¹,

Ryan²,

Tsochatzis³

2017

Ann. Transl. Med.

View full text Add to dashboard Cite

show abstract

“…Studies on evaluating liver disease by serum markers date back to 1970. N terminal propeptide of type III collagen (PIIINP) was the first serum marker suggested for liver fibrosis grading (10). The list of serum markers is long, the most common include; AST, ALT, bilirubin, alkaline phosphatase, albumin, prothrombin time, gamma glutamyltransferase, haptoglobin, apolipoprotein A1, α-2-macroglobin; collagen markers of type I, type II, type III, procollagen I carboxyl terminal peptide (PICP), procollagen IV C peptide, procollagen IV N peptide (7-S collagen), collagen IV, collagenases (metalloproteinase) and their inhibitors (tissue inhibitors of metalloproteinase), glycoproteins such as human cartilage glycoprotein (YKL-40), fibronectin, laminin, osteonectin, tenascin, glycosaminoglycans such as perlecan, hyaluronic acid, decorin, aggrecan, lumican, and fibromodulin (2, 9, 11).…”

Section: Evidence Acquisitionmentioning

confidence: 99%

“…In another study on discriminating those with and without cirrhosis, HA was the most efficient index among HA, N-acetyl-β-D-glucosaminidase, glucuronic acid, glucosamine and AST/ALT ratio (12). The applicability of serum HA levels to estimate liver necroinflammatory injuries, has also been approved in other studies (10, 29). …”

Section: Evidence Acquisitionmentioning

confidence: 99%

“…Seven et al measured nine serum fibrosis markers including tissue inhibitor of metalloproteinase 1 (TIMP-1), tenascin-C, PIIINP, laminin, matrix metalloproteinase-2 and 9, collagen type IV, collagen type VI and hyaluronan to predict advanced liver disease in patients with chronic hepatitis B. They observed that levels of TIMP1 and HA and finally their combination are powerful markers amongst other measured serum fibrosis markers to be used instead of a liver biopsy (10). …”

Section: Evidence Acquisitionmentioning

confidence: 99%

See 1 more Smart Citation

Hyaluronic Acid: From Biochemical Characteristics to its Clinical Translation in Assessment of Liver Fibrosis

Mansoor

Parsian

2013

Hepat Mon

View full text Add to dashboard Cite

Context:Hyaluronic acid (HA) is a high molecular weight polysaccharide that is distributed in all bodily tissues and fluids. The liver is the most important organ involved in the synthesis and degradation of HA. Research has shown that liver cell injury can affect serum HA levels. In this review, authors aimed to describe the biochemical and physiological roles of this glycosaminoglycan and its changes in various liver diseases.Evidence Acquisition:Liver fibrosis and in more severe form, cirrhosis are results of an imbalance between fibrogenesis and fibrinolysis. Liver biopsy is the gold standard to assess liver necro inflammatory injuries. This method is invasive and has some major side effects; therefore it is an unfavorable method for both physicians and patients. Now, a wide variety of noninvasive methods have been introduced based on evaluating serum level of different markers. They are safe, readily available, and more favorable. Serum HA levels are used by some researchers to assess stages of liver fibrosis.Results:There are several scientific studies indicating HA as a biomarker for high score fibrosis and cirrhosis in various liver diseases alone or in algorithm models. It seems from various algorithm models that the use of HA as a major constituent has more diagnostic reliability and accuracy than the use of HA alone.Conclusions:Use of HA in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of HA as an appropriate clinical tool.

show abstract

“…CIV and PIIINP are collagens that reflect extracellular matrix collagen turnover . Recent studies have shown that HA, LN, CIV, and PIIINP are correlated with advanced fibrosis . However, their use in distinguishing between inflammation stages has not been well established.…”

Section: Introductionmentioning

confidence: 99%

Serum liver fibrosis markers discriminate significant liver inflammation in chronic hepatitis B patients with normal or near‐normal alanine aminotransferase

Liao

Gong

Zhou

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Chronic liver inflammation caused by chronic hepatitis B virus (CHB) infection leads to liver cirrhosis and hepatocellular carcinoma. Recently, the role of alanine aminotransferase (ALT) as a predictor of liver inflammation has been questioned. The aim of this study was to investigate the utility of noninvasive fibrosis markers including hyaluronic acid (HA), collagen type IV (CIV), N‐terminal propeptide of type III procollagen (PIIINP), and laminin (LN) in identifying significant liver inflammation in patients with CHB, especially in patients with normal or near‐normal ALT. A total of 242 CHB patients who underwent liver biopsy were enrolled. The serum levels of ALT, aspartate aminotransferase, HA, CIV, PIIINP, and LN were quantified and the relationship between histological staging and serum markers was systematically analyzed. Serum CIV, PIIINP, HA, and LN levels increased significantly along with the increasing severity of liver inflammation. Multivariate analysis showed that CIV and LN were independently associated with significant inflammation. CIV, PIIINP, HA, and LN levels were found to have high diagnostic values for predicting significant inflammation in patients with CHB (area under the curve, AUC = 0.807, 0.795, 0.767, and 0.703, respectively). The combined index for the identification of significant inflammation, including CIV, PIIINP, HA, and LN levels, significantly improved diagnostic performance (AUC = 0.851). Moreover, the combined index also achieved excellent diagnostic accuracy (AUC = 0.861) in patients with CHB with normal or near‐normal ALT. In conclusion, the combined index may be a strong indicator for discriminating significant liver inflammation, especially in patients with CHB with normal or near‐normal ALT.

show abstract

Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D

Abstract: Amaç: Karaci¤er fibrozisinin biyopsi ile de¤erlendirilmesi invaziv bir yöntemdir ve örnekleme hatas›na yol açabilir. Fibrozis evresini öngö-ren serum fibrozis belirteç algoritmalar› kronik hepatit C'de tan›mlanm›fl olmas›na ra¤men, kronik hepatit B'de benzer

Cited by 17 publications

References 60 publications

Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection

Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection

Hyaluronic Acid: From Biochemical Characteristics to its Clinical Translation in Assessment of Liver Fibrosis

Serum liver fibrosis markers discriminate significant liver inflammation in chronic hepatitis B patients with normal or near‐normal alanine aminotransferase

Contact Info

Product

Resources

About