Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2

Abstract

Aim:The present study was intended to establish the role of bone in grade III obese women with and without type 2 diabetes mellitus (T2DM). Material & Methods:Serum osteocalcin (OC), Beta Cross-Laps (Beta-CTx), parathormone (PTH) separar and y 25-hydroxyvitamin D (25OHD) concentrations were measured in 48 morbid obesity women (11 with T2DM and 37 control group). Insulin resistance and insulin secretion was assessed by measuring the HOMA-IR and the HOMAβ index and its association with OC and Beta-CTx.Results: Serum OC was signifi cant lower in the diabetic group compared with non-diabetic patients 15.4 ± 3.6 ng/ml vs 22.1 ± 3.5 ng/ml, p<0.001 without signifi cant differences in Beta-CTx (0.24 ± 0.1 vs 0.31 ± 0.2 ng/ml, ns). Both bone biomarkers, OC and Beta-CTx, showed a positive correlation (r=0.76; p<0.01) in the whole group subjects and in the control group (r=0.80, p<0.00), but no in the T2DM group (r=0.50, p ns). In the whole group of patients, OC correlated signifi cantly with HOMA-IR (r=0.36; p<0.01) and HOMA-ß (r=0.36, p<0.01). Beta-CTx also correlated with HOMA-IR (r= 0.40, p<0.01) and HOMA-ß (r= 0.41, p<0.001. OC also signifi cantly correlated with HOMA-IR (r=0.41, p<0.01) in non-diabetic patients and almost reached statistical signifi cance with HOMA-ß (r=0.32, p=0.053), but was not signifi cantly correlated with HOMA-ß (r= -0.53, ns) and with HOMA-IR index (r=0.52, ns) in the T2DM group. When we performed the multivariate logistic regression the serum level of OC was the only covariate found signifi cantly with DM2 with a coefi cient -6.65 , (95% CI, -12.75049 -.5674469 ); p = 0.03). Both groups showed secondary hyperparathyroidism (T2DM, 78.4 ± 19.4 pg/ml vs non-diabetic group, 75.4 ± 35.6 pg/ ml; ns). The majority of the patients showed 25OHD defi ciency 62.5%, followed by 25OHD insuffi ciency 27.1% and normal 25OHD levels in only 10.4%. The 25OHD defi ciency was present in both study groups (T2DM patients, 18.3 ± 7.4 pg/ml and nondiabetic group, 19.7 ± 9.6 pg/ml; ns). Conclusion: OC and Beta-CTx could play a role in glucose metabolism and insulin resistance. Serum OC concentrations are signifi cantly reduced in T2DM morbidily obese women compared with nondiabetic group, and add new evidence on the possible role of bone as an endocrine organ with metabolic implications specially the levels of OC. Citation: Arrieta F, Iglesias P, Piñera M, Arrieta A,Quiñones J, et al. (2017) Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2. Glob J Obes Diabetes Metab Syndr 4(3): 072-076.

Роль Маркера Костного Ремоделирования Остеокальцина В Регуляции Энергетического Гомеостаза При Сахарном Диабете 2 Типа

“…При заболевании сахарным диабетом отмечаются негативные изменения костной ткани, включая костную структуру, плотность костной ткани и биохимические маркеры костного обмена [20,26,48]. Опубликованные результаты целого ряда систематических обзоров клинических исследований подтверждают обратные ассоциации между уровнем остеокальцина в сыворотке крови с риском и тяжестью дисметаболических состояний, таких как инсулинорезистентность, метаболический синдром, сахарный диабет 2 типа [3,21,25,43].…”