Serum concentrations of organochlorine compounds during pregnancy and the newborn

Roncević, N; Pavkov, S.; Galetin-Smith, R.; Vukavić, Tamara; M, Vojinović; Djordjević, Miljana

doi:10.1007/bf01606568

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…Decreases in plasma DDE and β-HCH concentrations were observed among five women providing specimens approximately 240 days (mean=8.4 and 4.5 parts per billion (ppb), respectively) prior to and approximately six days (mean=2.4 and 1.2 ppb, respectively) following delivery. In a study of 14 gravid women conducted in the former country of Yugoslavia (Roncevic et al 1987), women providing blood specimens six and three months prior to and at, delivery demonstrated increases in geometric mean sera concentrations for β-HCH (1.28, 1.41, 1.45 µg/L serum, respectively) and DDE (6.61, 6.14, and 7.57 µg/L serum, respectively), though none achieved statistical significance. More recently, a Canadian study of 105 pregnant women with sera concentrations of DDE and HCB similar to those measured in the current study (Jarrell et al 2005) reported no statistically significant difference in arithmetic/geometric mean concentrations measured during the 2 nd trimester (i.e., 0.30/0.26 and 0.12/0.10 ng/g serum, respectively) and at delivery (i.e., 0.33/0.27 and 0.13/0.10 ng/g serum, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Data addressing this question in the literature are sparse. While fairly recent publications have reported stable maternal organochlorine/metabolite blood concentrations across gestation (Jarrell et al 2005; Longnecker et al 1999), early evidence suggests otherwise (Curley and Kimbrough 1969; Roncevic et al 1987). To address this critical data gap, we assessed concentrations of serum organochlorine pesticides/metabolites across critical windows of human reproduction and development commencing with preconception quantification.…”

Section: Introductionmentioning

confidence: 99%

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Changes in maternal serum chlorinated pesticide concentrations across critical windows of human reproduction and development

Bloom

Louis

Schisterman

et al. 2009

Environmental Research

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Investigators often employ a single cross-sectional measure of in utero exposure when evaluating associations between organochlorine pesticides/ metabolites (OCs) and adverse reproductive outcomes. Few data are available on the stability of exposures to OCs over critical windows of human reproduction and development inclusive of the periconception window. Our objective was to measures changes in OC concentrations prior to conception and throughout pregnancy or after 12 unsuccessful months attempting pregnancy. Seventy-nine women planning pregnancy were prospectively enrolled and followed for up to 12 menstrual cycles. Blood specimens were obtained for toxicologic analysis of seven OCs from participating women at baseline (preconception, n=79), at the first prenatal visit following a positive pregnancy test leading to a live birth (n=54) or after pregnancy loss (n=10), at approximately 6 weeks post-partum (n=53), and after 12 unsuccessful cycles (n=9). Overall and daily rate of change in OCs concentration (ng/g serum) were estimated adjusting for serum lipids and baseline concentration. Significant (P<0.05) decreases in the overall and daily rate of change in OCs concentrations (ng/mL serum) were observed from baseline to pregnancy for HCB (−0.032, −0.001, respectively) and trans-nonachlor (−0.050, −0.002, respectively) while oxychlordane demonstrated an increase during this critical window (0.029, 0.001, respectively). Significant decreases in aldrin (−0.002, −1.47 × 10 −4 , respectively), HCB (−0.069, −0.003, respectively), and trans-nonachlor (−0.045, −0.002 respectively), and an overall increase for oxychlordane (0.015) were seen for women with pregnancy losses. Significant decreases also were observed among infertile women for aldrin (−0.003, −3.52 × 10 −6 , respectively), DDE (−0.210, −4.29 × 10 −4 , respectively), and HCB (−0.096, −2.03 × 10 −4 , respectively), along with an increase for transnonachlor (0.034, 7.59 × 10 −5 , respectively). These data, though limited by sample size and the possibility of laboratory measurement error, suggest that OC concentrations may change over critical windows. This underscores the importance of timing biospecimen collection to critical windows for development in the assessment of reproductive and/or developmental effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in maternal serum chlorinated pesticide concentrations across critical windows of human reproduction and development

Bloom

Louis

Schisterman

et al. 2009

Environmental Research

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“…Studies assessing the influence of weight change on organochlorine change have been few, particularly for long term trends (8, 12, 44-46). Increased fat as a result of weight gain may lead to the dilution of organochlorine concentrations, thereby resulting in a negative association between body fat and serum organochlorine levels (47).…”

Section: 6 Discussionmentioning

confidence: 99%

Dichlorodiphenyldichloroethane and Polychlorinated Biphenyls: Intraindividual Changes, Correlations, and Predictors in Healthy Women from the Southeastern United States

Gladen

Cooper

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Dichlorodiphenyldichloroethane (DDE) and polychlorinated biphenyls (PCBs) are widespread environmental contaminants that have been postulated to increase the risk of diseases such as non-Hodgkin's lymphoma, breast cancer, as well as lead to early menopause. Studies assessing the effect of organochlorine exposure often can only measure organochlorine levels once, such as at study enrollment which may not be an etiologically relevant time period. We assessed the temporal changes in DDE and PCBs and the predictors of those changes using interview data and DDE/PCB measures collected from 123 women who were enrolled in a baseline study from 1978-1982 and followed up in 2003-2004. Baseline and follow-up organochlorine levels were compared using Spearman correlations (rs) and predictors of the rate of change in log concentration were evaluated using linear regression models. While serum concentrations dramatically declined (median follow-up to baseline concentration ratio was 16% for DDE and 45% for PCBs), baseline and follow-up measures were strongly correlated for DDE (rs=0.72) and moderately correlated for PCBs (rs=0.43). Prediction of follow-up PCB levels was substantially improved (rs=0.75) with data on initial concentration, length of lactation, baseline body mass index and percent change in body fat, while DDE prediction improved slightly (rs=0.83) with data on lactation and baseline body mass index. These findings suggest that a single organochlorine measure provides considerable information on relative ranking at distant times and that the predictive power can be improved, particularly for PCBs, with information on a few predictors.

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“…There have been a dozen studies to investigate the variation of POP levels in sequential maternal blood samples across pregnancy [ 13 , 14 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 37 , 46 , 47 , 48 , 49 ]. Unfortunately, most published literature focused on the level differences (significant or insignificant) and/or variation patterns (increasing, decreasing, or stable), discussion on the variation extent in POP levels throughout pregnancy was restricted [ 16 , 21 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison of Dechlorane Plus Concentrations in Sequential Blood Samples of Pregnant Women in Taizhou, China

Wan

et al. 2022

Molecules

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To develop an appropriate sampling strategy to assess the intrauterine exposure to dechlorane plus (DP), we investigated DP levels in sequential maternal blood samples collected in three trimesters of pregnancy, respectively, from women living in Taizhou. The median concentration of DPs (sum of syn-DP and anti-DP) in all samples was 30.5 pg g−1 wet-weight and 5.01 ng g−1 lipid-adjusted weight, respectively. The trimester-related DP concentrations were consistently strongly correlated (p < 0.01), indicating that a single measurement of DP levels could represent intrauterine exposure without sampling from the same female repeatedly; however, the wet-weight levels significantly increased across trimesters (p < 0.05), while the lipid-adjusted levels did not significantly vary. Notably, whether lipid-adjusted weight or wet-weight levels, the variation extent of DP across trimesters was found to be less than 41%, and those for other persistent organic pollutants (POPs) reported in the literature were also limited to 100%. The limitation in variation extents indicated that, regardless of the time of blood collection during pregnancy and how the levels were expressed, a single measurement could be extended to screen for exposure risk if necessary. Our study provides different strategies for sampling the maternal blood to serve the requirement for assessment of in utero exposure to DP.

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Serum concentrations of organochlorine compounds during pregnancy and the newborn

Cited by 10 publications

References 14 publications

Changes in maternal serum chlorinated pesticide concentrations across critical windows of human reproduction and development

Changes in maternal serum chlorinated pesticide concentrations across critical windows of human reproduction and development

Dichlorodiphenyldichloroethane and Polychlorinated Biphenyls: Intraindividual Changes, Correlations, and Predictors in Healthy Women from the Southeastern United States

Comparison of Dechlorane Plus Concentrations in Sequential Blood Samples of Pregnant Women in Taizhou, China

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