Serum Concentrations of Interferon Gamma (IFN- and #947;) in Patients with Psoriasis: Correlation with Clinical Type and Severity of the Disease

Abstract

Introduction: The etiopathogenesis of psoriasis is still unclear but there is evidence that many of cytokines released by keratinocytes and inflammatory leukocytes may contribute to the induction or persistence of the inflammatory process in psoriasis. Aim: The aim of the study was to evaluate serum concentrations of Interferon gamma (IFN-γ) in patients with psoriasis and the healthy subjects and also to assess a possible association between IFN-γ, clinical type and severity of disease. Material and Methods: The study included a total of 60 patients with psoriasis and 20 healthy subjects in the control group. According to the clinical type of disease, patients with psoriasis were divided into four groups: psoriasis vulgaris (PV), psoriasis erythrodermica (PE), psoriasis pustulosa (PP) and psoriasis arthropatica (PA). Blood samples were collected from all psoriasis patients and from healthy control subjects. Serum IFN-γ levels were measured by an enzyme-linked immunosorbent assay (ELISA) technique. The severity of PV was assessed by Psoriasis Area and Severity Index (PASI) score. Results: The serum concentration of IFN-γ in patients with psoriasis was significantly higher than that in the control group (1.91±1.79 pg/mL vs 0.91±0.38 pg/mL, respectively). Significantly elevated serum IFN-γ concentrations were noticed in patients with PV (2.15±0.30 pg/mL). There was no statistically significant difference between the mean values of IFN- γ compared to the clinical type of psoriasis (p>0.05). In the group of patients with PV 36 (85.71%) patients had mild form of disease with PASI <50, and 6 (14.29%) patients had severe disease with PASI >50. It was not found statistically significant correlation between serum IFN-γ level and PASI score in the group of PV. Conclusions: The results of our study indicate that psoriasis is associated with significant changes in the serum concentration of IFN-γ. There was no significant correlation between serum IFN-γ concentrations, clinical type of psoriasis and severity of PV evaluated with the use of PASI score.

Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation

“…Since portal blood from healthy individuals is not accessible without invasive intervention, portal blood control samples could not be ethically obtained for comparison. Therefore, portal and peripheral blood samples were compared to manufacturer/literature cited mean or median values for healthy human peripheral blood plasma (mean 33.7pg/ml GM-CSF, BioLegend, mean 83.7pg/ml M-CSF, BioLegend, mean 7.13pg/ml IL-34 [ 23 ], median 83pg/ml IL-8 [ 24 ], mean 1.91pg/ml IFNγ [ 25 ], mean 0.74pg/ml IL1α [ 26 ], mean 1.85pg/ml IL1β [ 27 ], mean 312pg/ml PGE2, ThermoFisher).…”

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

“…Several autoimmune diseases, such as psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and multiple sclerosis (MS), are characterized by elevated amounts of IL-23 [ 41 ]. Psoriasis is a disease in which IFN-γ [ 42 ] and IL-17 [ 43 ] play an important role, hence the significance of IL-23 in the pathogenesis of this disease is not surprising. Interestingly, unlike in our studies on patients with depression, serum IL-23 levels in patients with psoriasis were negatively correlated with disease duration.…”

Orchestrated Cytokines Mediated by Biologics in Psoriasis and Its Mechanisms of Action

“…Earlier data suggested that all clinical types of psoriasis, namely, plague, erythrodermic and guttate, concluded a significant positive correlation between PASI score and high levels of IFN-γ [ 153 ]. The role of IFN-γ in psoriasis vulgaris remains to be discovered, since there is no relationship between highly elevated IFN-γ with both the mean values of IFN-γ and PASI score [ 154 ]. Other previous findings are in an agreement with this different pattern; elevated IFN-γ may or may not correlate with the PASI score [ 155 ].…”

“…Other previous findings are in an agreement with this different pattern; elevated IFN-γ may or may not correlate with the PASI score [ 155 ]. The disparity of findings suggested that IFN-γ may play a role in psoriasis pathogenesis, but this is somewhat ambiguous; therefore, it is not considered to be the definite regulator or a single player in the overall pathways [ 153 , 154 ]. Nevertheless, it still contributes to the psoriasis cytokine storm; hence, other postulations suggested that IFN-γ is synergic with TNF-α.…”