2018
DOI: 10.5455/medarh.2018.72.410-413
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Serum Concentrations of Interferon Gamma (IFN- and #947;) in Patients with Psoriasis: Correlation with Clinical Type and Severity of the Disease

Abstract: Introduction: The etiopathogenesis of psoriasis is still unclear but there is evidence that many of cytokines released by keratinocytes and inflammatory leukocytes may contribute to the induction or persistence of the inflammatory process in psoriasis. Aim: The aim of the study was to evaluate serum concentrations of Interferon gamma (IFN-γ) in patients with psoriasis and the healthy subjects and also to assess a possible association between IFN-γ, clinical type and sev… Show more

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Cited by 34 publications
(19 citation statements)
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“…Since portal blood from healthy individuals is not accessible without invasive intervention, portal blood control samples could not be ethically obtained for comparison. Therefore, portal and peripheral blood samples were compared to manufacturer/literature cited mean or median values for healthy human peripheral blood plasma (mean 33.7pg/ml GM-CSF, BioLegend, mean 83.7pg/ml M-CSF, BioLegend, mean 7.13pg/ml IL-34 [ 23 ], median 83pg/ml IL-8 [ 24 ], mean 1.91pg/ml IFNγ [ 25 ], mean 0.74pg/ml IL1α [ 26 ], mean 1.85pg/ml IL1β [ 27 ], mean 312pg/ml PGE2, ThermoFisher).…”
Section: Methodsmentioning
confidence: 99%
“…Since portal blood from healthy individuals is not accessible without invasive intervention, portal blood control samples could not be ethically obtained for comparison. Therefore, portal and peripheral blood samples were compared to manufacturer/literature cited mean or median values for healthy human peripheral blood plasma (mean 33.7pg/ml GM-CSF, BioLegend, mean 83.7pg/ml M-CSF, BioLegend, mean 7.13pg/ml IL-34 [ 23 ], median 83pg/ml IL-8 [ 24 ], mean 1.91pg/ml IFNγ [ 25 ], mean 0.74pg/ml IL1α [ 26 ], mean 1.85pg/ml IL1β [ 27 ], mean 312pg/ml PGE2, ThermoFisher).…”
Section: Methodsmentioning
confidence: 99%
“…Several autoimmune diseases, such as psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and multiple sclerosis (MS), are characterized by elevated amounts of IL-23 [ 41 ]. Psoriasis is a disease in which IFN-γ [ 42 ] and IL-17 [ 43 ] play an important role, hence the significance of IL-23 in the pathogenesis of this disease is not surprising. Interestingly, unlike in our studies on patients with depression, serum IL-23 levels in patients with psoriasis were negatively correlated with disease duration.…”
Section: Discussionmentioning
confidence: 99%
“…Earlier data suggested that all clinical types of psoriasis, namely, plague, erythrodermic and guttate, concluded a significant positive correlation between PASI score and high levels of IFN-γ [ 153 ]. The role of IFN-γ in psoriasis vulgaris remains to be discovered, since there is no relationship between highly elevated IFN-γ with both the mean values of IFN-γ and PASI score [ 154 ]. Other previous findings are in an agreement with this different pattern; elevated IFN-γ may or may not correlate with the PASI score [ 155 ].…”
Section: Other Pro-inflammatory Cytokines Candidatesmentioning
confidence: 99%
“…Other previous findings are in an agreement with this different pattern; elevated IFN-γ may or may not correlate with the PASI score [ 155 ]. The disparity of findings suggested that IFN-γ may play a role in psoriasis pathogenesis, but this is somewhat ambiguous; therefore, it is not considered to be the definite regulator or a single player in the overall pathways [ 153 , 154 ]. Nevertheless, it still contributes to the psoriasis cytokine storm; hence, other postulations suggested that IFN-γ is synergic with TNF-α.…”
Section: Other Pro-inflammatory Cytokines Candidatesmentioning
confidence: 99%