Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet

Janas, Roman; Rybak, Anna; Wierzbicka-Rucińska, Aldona; Socha, Piotr; Śnitko, Rafał; Szaflarska-Popławska, Anna; Stolarczyk, Anna; Oralewska, Beata; Cytra-Jarocka, Elżbieta; Iwańczak, Barbara; Grzybowska-Chłebowczyk, Urszula; Cichy, Wojciech; Czaja‐Bulsa, Grażyna; Socha, Jerzy

doi:10.5009/gnl15404

Cited by 11 publications

(6 citation statements)

References 42 publications

(55 reference statements)

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“…Discrepancies between the above-mentioned reports may indicate a complex relationship between ghrelin and GERD. Theoretically, high ghrelin levels may lead to GERD by increasing the secretion of gastric juice and decreasing its pH or may also result from esophageal wall lesions as a result of the inflammatory process, as in the case of IBD or celiac disease [ 40 , 65 , 66 ]. On the other hand, ghrelin stimulates stomach motility; thus, decreased levels of ghrelin prolong the duration of gastric emptying, which may be conducive to GERD.…”

Section: Discussionmentioning

confidence: 99%

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Pardak

Filip

Woliński

et al. 2021

JCM

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Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; n = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (p5.00 = 0.0207; p7.00 = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. No significant differences in hormonal levels were observed between the groups depending on the diagnosis of GERD. However, correlations of ghrelin levels with the severity of esophagitis, leptin and ghrelin levels with the severity of GERD symptoms, and leptin levels with lower esophageal pH were found. GERD is more frequent among patients with OSA. In both GERD and OSA, deviations were observed in the levels of ghrelin and leptin. However, our analysis demonstrates that the relationship between OSA and GERD does not result from these disorders.

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Section: Discussionmentioning

confidence: 99%

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Pardak

Filip

Woliński

et al. 2021

JCM

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“…Additionally, the expression of LCN2, the gene that encodes lipocalin-2, is increased in the duodenum of patients with environmental enteric dysfunction, another small bowel enteropathy with histopathologic similarities to celiac disease (12,13). A prior study found no elevation of plasma lipocalin-2 in patients with celiac disease (14). While immunohistochemistry for lipocalin-2 shows staining in small bowel biopsies of children with celiac disease and not in healthy controls, a difference was not found on quantification (13).…”

Section: Introductionmentioning

confidence: 87%

Non-Invasive markers of inflammation and protein loss augment diagnosis of celiac disease

Sutton

et al. 2023

Preprint

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BackgroundCirculating tissue transglutaminase IgA (TTG IgA) concentrations are sensitive and specific indicators of celiac disease, but discrepancies between serologic and histologic findings still occur. We hypothesized that fecal markers of inflammation and protein loss would be greater in patients with untreated celiac disease than in healthy controls. Our study aims to evaluate multiple fecal and plasma markers in celiac disease and correlate these findings with serologic and histologic findings as non-invasive means of evaluating disease activity.MethodsParticipants with positive celiac serologies and controls with negative celiac serologies were enrolled at the time of upper endoscopy. Blood, stool and duodenal biopsies were collected. Concentrations of fecal lipocalin-2, calprotectin and alpha-1-antitrypsin and plasma lipcalin-2 were determined. Biopsies underwent modified Marsh scoring. Significance was tested between cases and controls, modified Marsh score and TTG IgA concentration.ResultsLipocalin-2 was significantly elevated in the stool (p=0.007) but not the plasma of participants with positive celiac serologies compared to controls. There was no significant difference in fecal calprotectin or alpha-1 antitrypsin between participants with positive celiac serologies and controls. Fecal alpha-1 antitrypsin >100mg/dL was specific, but not sensitive for biopsy proven celiac disease.ConclusionsLipocalin-2 is elevated in the stool but not the plasma of patients with celiac disease suggesting a role in the local inflammatory response. Calprotectin was not a useful marker in the diagnosis of celiac disease and did not correlate with degree of histologic changes on biopsy. While random fecal alpha-1 antitrypsin was not significantly elevated in cases compared to controls, an elevation of greater than 100mg/dL was 90% specific for biopsy proven celiac disease.

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“…On the other hand, excessive sOB-R could inhibit leptin binding to membrane receptors so that leptin failed to play an effective role on reducing caloric intake, increasing energy expenditure as well as evoking GnRH and LH secretion in vivo [28,29]. Prior studies mentioned that sOB-R levels were not directly related to leptin or body fatness, and presumably mediated by other parameters related to nutrition and energy metabolism [26]. Therefore, the plasma sOB-R levels as a potential factor of PCOS independent of leptin and BMI, can be recommended as a novel indicator of PCOS severity.…”

Section: Discussionmentioning

confidence: 99%

“…However, whether the serum leptin receptor levels had a correlation with the quantity of the total fat mass has not been confirmed. In the previous studies, researchers demonstrated the significant correlation between serum sOB-R and BMI in a cohort of healthy children and adolescents [26]; and Sun and colleagues showed that the two nonsynonymous SNPs in the LEPR gene were associated with plasma sOB-R levels at the genome-wide significance level, which highlighted and confirmed the role of LEPR as a candidate gene for regulating sOB-R levels [27]. The above conflicting data might reflect variations in the study design and population stratification.…”

Section: Discussionmentioning

confidence: 99%

LEPR Gene Polymorphism and Plasma Soluble Leptin Receptor Levels are Associated with Polycystic Ovary Syndrome in Han Chinese Women

Gao

et al. 2017

Per. Med.

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Aim:To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women. Patients & methods: LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured. Results: The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups. Plasma sOB-R levels increased significantly in PCOS patients and were associated with PCOS independent of BMI. Furthermore, luteinizing hormone, triglyceride and fasting blood glucose correlated significantly to PCOS patients' sOB-R levels. Conclusion: LEPR Lys109Arg (rs1137100) was associated with PCOS susceptibility and genotype AA was deduced to be a protective factor for PCOS; sOB-R levels might be recognized as a new indicator for the severity of PCOS.

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Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet

Cited by 11 publications

References 42 publications

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Non-Invasive markers of inflammation and protein loss augment diagnosis of celiac disease

LEPR Gene Polymorphism and Plasma Soluble Leptin Receptor Levels are Associated with Polycystic Ovary Syndrome in Han Chinese Women

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