Serum concentrations of 3,3'-diiodothyronine, 3',5'-diiodothyronine, and 3,5-diiodothyronine in altered thyroid states.

Nishikawa, Mitsushige; Inada, Mitsuo; Naito, Koichi; Ishii, Hitoshi; Tanaka, Kiyoshi; Mashio, Yasuo; Imura, Hiroo

doi:10.1507/endocrj1954.30.167

Cited by 7 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with results reported in previous studies on euthyroid humans, we measured markedly higher median serum 3,5-T2 concentration (15)(16)(17)(18)(19)(29)(30)(31)(32)(33). One possible explanation might be the brief incubation time of almost one hour in most polyclonal antibody-based RIAs compared with the overnight incubation performed in our monoclonal antibody immunoassay.…”

Section: Discussioncontrasting

confidence: 61%

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Pietzner

Lehmphul

Friedrich

et al. 2015

Thyroid

View full text Add to dashboard Cite

Background: During the last two decades, it has become obvious that 3,5-diiodothyronine (3,5-T2), a wellknown endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the former but also exhibits specific metabolic activities. Administration of 3,5-T2 to hypothyroid rodents rapidly stimulated their basal metabolic rate, prevented highfat diet-induced obesity as well as steatosis, and increased oxidation of long-chain fatty acids. Objective: The aim of the present study was to analyze associations between circulating 3,5-T2 in human serum and different epidemiological parameters, including age, sex, or smoking, as well as measures of anthropometry, glucose, and lipid metabolism. Methods: 3,5-T2 concentrations were measured by a recently developed immunoassay in sera of 761 euthyroid participants of the population-based Study of Health in Pomerania. Subsequently, analysis of variance and multivariate linear regression analysis were performed. Results: Serum 3,5-T2 concentrations exhibited a right-skewed distribution, resulting in a median serum concentration of 0.24 nM (1st quartile: 0.20 nM; 3rd quartile: 0.37 nM). Significant associations between 3,5-T2 and serum fasting glucose, thyrotropin (TSH), as well as leptin concentrations were detected ( p < 0.05). Interestingly, the association to leptin concentrations seemed to be mediated by TSH. Age, sex, smoking, and blood lipid profile parameters did not show significant associations with circulating 3,5-T2. Conclusion: Our findings from a healthy euthyroid population may point toward a physiological link between circulating 3,5-T2 and glucose metabolism.

show abstract

Section: Discussioncontrasting

confidence: 61%

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Pietzner

Lehmphul

Friedrich

et al. 2015

Thyroid

View full text Add to dashboard Cite

show abstract

“…The pathways involved in the formation and clearance of the T2 are currently unknown [45][46][47]. Previous studies showed that T2 production from the T3 hormone might be less prominent in hypothyroid patients treated with L-T4 [48]. These data could suggest a possible involvement of changes in T2 levels in PTCA if the decrease after TT is proven.…”

Section: Discussionmentioning

confidence: 97%

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Scerrino¹,

Raspanti²,

Attard³

et al. 2017

Langenbecks Arch Surg

View full text Add to dashboard Cite

Purpose Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Graves' disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre-and postoperative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

show abstract

“…However, serum TAGs, which are high in HFD-fed rats, appear to be normalised by T 2 treatment, as previously reported by us and others (Lanni et al 2005, Grasselli et al 2008, so that an increase in trigliceridemia by T 2 is not apparent, despite the possible stimulation of VLDL secretion. The VLDL receptor number is increased in the muscle of hyperthyroid rats (Jokinen et al 1994), and TH administration increases serum levels of T 2 (Nishikawa et al 1983). Therefore, it could be hypothesised that the increased rate of VLDL secretion induced by T 2 might be balanced by an increase in plasma VLDL removal rate by skeletal muscle, or other tissues.…”

Section: Discussionmentioning

confidence: 99%

3,5-Diiodo-l-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver

Grasselli¹,

Voci²,

Demori³

et al. 2011

Journal of Endocrinology

View full text Add to dashboard Cite

Recent reports demonstrated that 3,5-diiodo-L-thyronine (T 2 ) was able to prevent lipid accumulation in the liver of rats fed a high-fat diet (HFD). In this study, we investigated how the rat liver responds to HFD and T 2 treatment by assessing the transcription profiles of some genes involved in the pathways of lipid metabolism: oxidation, storage and secretion. The mRNA levels of the peroxisome proliferator-activated receptors (PPARa, PPARg and PPARd), and of their target enzymes acyl-CoA oxidase and stearoyl-CoA desaturase were evaluated by real-time RT-PCR. Moreover, the expression of the adipose triglyceride lipase involved in lipid mobilisation, of the main PAT proteins acting in lipid droplet (LD) turnover, and of apoprotein B (apo B), the major protein component of very low-density lipoproteins (VLDLs) were analysed. Overall, our data demonstrated that T 2 administration to HFD rats counteracts most of the hepatic transcriptional changes that occurred in response to the excess exogenous fat. In particular, our results suggest that T 2 may prevent the pathways leading to lipid storage in LDs, promote the processes of lipid mobilisation from LDs and secretion as VLDL, in addition to the stimulation of pathways of lipid oxidation. In conclusion, our findings might give an insight into the mechanisms underlying the anti-steatotic ability of T 2 and help to define the potential therapeutic role of T 2 for preventing or treating liver steatosis.

show abstract

Serum concentrations of 3,3'-diiodothyronine, 3',5'-diiodothyronine, and 3,5-diiodothyronine in altered thyroid states.

Cited by 7 publications

References 12 publications

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

3,5-Diiodo-l-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver

Contact Info

Product

Resources

About