Serum concentrations and tissue expression of components of insulin-like growth factor-axis in females with type 2 diabetes mellitus and obesity: The influence of very-low-calorie diet

Toušková, Věra; Trachta, Pavel; Kaválková, Petra; Drápalová, J.; Haluzíková, D; Mráz, Miloš; Lacinová, Z; Jakóbisiak, Marek; Haluzı́k, Martin

doi:10.1016/j.mce.2012.04.005

Cited by 29 publications

(18 citation statements)

References 41 publications

(40 reference statements)

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“…In our previous studies, we have demonstrated the beneficial effect of various weight reduction methods on the metabolic and proinflammatory profile of obese patients both with and without type 2 diabetes mellitus (Mraz et al 2011, Touskova et al 2012, Urbanova et al 2014. In this study, we investigated whether very-lowcalorie diet (VLCD) and laparoscopic sleeve gastrectomy (LSG) affect plasma clusterin concentrations or its mRNA expression in subcutaneous adipose tissue in obese patients with or without T2DM.…”

Section: Discussionmentioning

confidence: 93%

Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Kloučková

Lacinová²,

Kaválková³

et al. 2016

Physiol Res

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Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese women with type 2 diabetes mellitus (T2DM) who underwent a 2-week very low-calorie diet (VLCD), 10 obese women without T2DM who underwent laparoscopic sleeve gastrectomy (LSG) and 8 patients with T2DM, 8 patients with impaired glucose tolerance (IGT) and 8 normoglycemic patients who underwent hyperinsulinemic euglycemic clamp (HEC). VLCD decreased plasma clusterin in OB but not in T2DM patients while LSG and HEC had no effect. Clusterin mRNA expression in SCAT at baseline was increased in OB and T2DM patients compared with controls. Clusterin mRNA expression decreased 6 months after LSG and remained decreased 12 months after LSG. mRNA expression of clusterin was elevated at the end of HEC compared with baseline only in normoglycemic but not in IGT or T2DM patients. In summary, our data suggest a possible local regulatory role for clusterin in the adipose tissue rather than its systemic involvement in the regulation of energy homeostasis.

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Section: Discussionmentioning

confidence: 93%

Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Kloučková

Lacinová²,

Kaválková³

et al. 2016

Physiol Res

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“…Although circulating inflammatory cytokines originate from multiple sources [1, 3, 6], we may speculate that the anti-inflammatory effect of the exercise training was due, at least partially, to the reduction of adipose tissue mass and to the consequent reduced adipokine secretion in the EXE group. Notably, recent studies demonstrated that very low-calorie diet significantly reduced serum concentration and peripheral monocyte expression of proinflammatory markers and specific components of IGF-1 axis in adult nondiabetic [43] and diabetic [44] obese women. Accordingly, this study demonstrated that concurrent training increases fat-free mass along with muscle strength and endurance and is associated with an increase of IGF-1 plasma level and of its mRNA expression in PBMC.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients

Annibalini

Lucertini

Agostini

et al. 2017

Oxidative Medicine and Cellular Longevity

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Type 2 diabetes (T2D) is an age-related chronic disease associated with metabolic dysregulation, chronic inflammation, and activation of peripheral blood mononuclear cells (PBMC). The aim of this study was to assess the effects of a concurrent exercise training program on inflammatory status and metabolic parameters of T2D patients. Sixteen male patients (age range 55–70) were randomly assigned to an intervention group (n = 8), which underwent a concurrent aerobic and resistance training program (3 times a week; 16 weeks), or to a control group, which followed physicians' usual diabetes care advices. Training intervention significantly improved patients' body composition, blood pressure, total cholesterol, and overall fitness level. After training, plasma levels of adipokines leptin (−33.9%) and RBP4 (−21.3%), and proinflammatory markers IL-6 (−25.3%), TNF-α (−19.8%) and MCP-1 (−15.3%) decreased, whereas anabolic hormone IGF-1 level increased (+16.4%). All improvements were significantly greater than those of control patients. Plasma proteomic profile of exercised patients showed a reduction of immunoglobulin K light chain and fibrinogen as well. Training also induced a modulation of IL-6, IGF-1, and IGFBP-3 mRNAs in the PBMCs. These findings confirm that concurrent aerobic and resistance training improves T2D-related metabolic abnormalities and has the potential to reduce the deleterious health effects of diabetes-related inflammation.

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“…For example, the Ala54Thr FABP2 polymorphism was specifically associated with type 2 diabetes (T2DM) among Hispanic Americans [58], and a new SNP of FABP5 (rs454550) specifically associated with T2DM among non-Hispanic whites and African Americans [58]. Other markers in the biomarker profile of AD among Mexican Americans have also been associated with metabolic conditions including CD40 [60], glucagon-like peptide 1[61, 62], pancreatic polypeptide [63], β2-microglobulin [64], insulin-like-growth factor [65], peptide YY [66], insulin, and TSH [67]. Therefore, the current findings may point towards a metabolic endophenotype of AD among Mexican Americans and this possibility requires further attention.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Alzheimer's Disease Among Mexican Americans

O’Bryant¹,

Xiao

Edwards

et al. 2013

JAD

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Background Mexican Americans are the fastest aging segment of the U.S. population yet little scientific literature exists regarding the Alzheimer disease (AD) among this segment of the population. The extant literature suggests that biomarkers of AD will vary according to race/ethnicity though no prior work has explicitly studied this possibility. The aim of this study was to create a serum-based biomarker profile of AD among Mexican American. Methods Data were analyzed from 363 Mexican American participants (49 AD and 314 normal controls) enrolled in the Texas Alzheimer’s Research & Care Consortium (TARCC). Non-fasting serum samples were analyzed using a luminex-based multi-plex platform. A biomarker profile was generated using random forest analyses. Results The biomarker profile of AD among Mexican Americans was different from prior work from non-Hispanic populations with regards to the variable importance plots. In fact, many of the top markers were related to metabolic factors (e.g. FABP, GLP-1, CD40, pancreatic polypeptide, insulin-like-growth factor, and insulin). The biomarker profile was a significant classifier of AD status yielding an area under the receiver operating characteristic curve (AUC), sensitivity (SN) and specificity (SP) of 0.77, 0.92 and 0.64, respectively. Combining biomarkers with clinical variables yielded a better balance of SN and SP. Conclusion The biomarker profile for AD among Mexican American cases is significantly different from that previously identified among non-Hispanic cases from many large-scale studies. This is the first study to explicitly examine and provide support for blood-based biomarkers of AD among Mexican Americans. Areas for future research are highlighted.

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Serum concentrations and tissue expression of components of insulin-like growth factor-axis in females with type 2 diabetes mellitus and obesity: The influence of very-low-calorie diet

Cited by 29 publications

References 41 publications

Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients

Biomarkers of Alzheimer's Disease Among Mexican Americans

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