Serum Concentration of Prednisolone in Children with Nephrotic Syndrome

Abstract

139 1vorc.J.; Ste.~ekal.J.;Faculty of Pediatric.Charles Univereity, Praha, Czechoelovakia Experience with 103 children euffering from ne hrotic eyndrome with a follow up even for the perfod of 20 years is preeented. Congenital nephrotic eyndrome, differing from the finnieh type wee found twice. 69 children euffered from the mlnimal changee dieeaee. The affection mostly began in the preschool age.No correlation ae to the recovery or number of relapees in connection with age at oneet or with the freguency of adjoining allergic dieeaee could be found. The prognoeie wee excellent, none of the patiente died from renal ineufficiency in spite of the fact that they were obeerved even for 20 years. The moat dangerous complication was hypovolemic ahock and thromboeia of great veseele. The reeponee to prednieone wae moetly very good? cyclophosphamide was ueed in eome patlente, but Ita effect on gonads ahould not be forgotten. In 32 children with other types of nephrotic eyndrome 8 died in chronic renal failure and renal insufficiency developed in 3 othere. No therapy in thia group gave eatiefactory resulte with exception of eome caeee of lupue nephritis. Minimal changes disease differ8 dietinctly in clinical course and prognoeie from other forms of the primary nephrotic eyndrome.