Serum concentration of NSE and S-100b during LVAD in non-resuscitated patients

Pfeifer, Rüdiger; Ferrari, Markus; Börner, A.; Deufel, Thomas; Figulla, Hans R.

doi:10.1016/j.resuscitation.2008.04.016

Cited by 28 publications

(18 citation statements)

References 29 publications

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“…This subgroup analysis removed the potentially confusing factor of patients who had received IABP implantation, known to elevate NSE serum levels. 20 The conflict between our results and those in the literature are difficult to explain. It is unlikely to be because of differences in the details of TH.…”

Section: Discussioncontrasting

confidence: 80%

“…IABP can increase NSE levels by haemolysis. 20 Hence, we conducted a subgroup analysis of NSE and S-100b serum levels after excluding all patients that received IABP. We did not find any significant differences in the mean serum concentrations of either protein between these subgroups (results not depicted).…”

Section: Resultsmentioning

confidence: 99%

“…There are, furthermore, several factors other than CA that influence the serum concentrations of NSE levels such as haemolysis or several forms of cancer. 20,21,30 For S-100b, there is little consistency. Threshold serum values over the unbelievably wide range 0.2-1.5 μg/l have been proposed as predictors of poor neurological outcome.…”

Section: Fig 3 Box Plots With Median and Interquartile Ranges And 9mentioning

confidence: 99%

“…21,[23][24][25]28,30 Likewise, S-100b is released from tissues other than the brain such as adipocytes, chondrocytes, and several forms of cancer of the central nervous system and melanoma. 20,21 Moreover, serum levels of both proteins may differ between laboratories due to a lack of standardization. 31 In agreement with several other experts in the field, we were able to demonstrate that, in patients with poor neurological outcome, serum levels of NSE and S-100b increase further and remarkably after CA peaking at day three after ROSC, irrespective of TH.…”

Section: Fig 3 Box Plots With Median and Interquartile Ranges And 9mentioning

confidence: 99%

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Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Pfeifer

Franz

Figulla

2014

Acta Anaesthesiol Scand

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Section: Discussioncontrasting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Fig 3 Box Plots With Median and Interquartile Ranges And 9mentioning

confidence: 99%

Section: Fig 3 Box Plots With Median and Interquartile Ranges And 9mentioning

confidence: 99%

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Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Pfeifer

Franz

Figulla

2014

Acta Anaesthesiol Scand

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“…Serum S100B is influenced by diet and by body weight gain (Holtkamp et al, 2008). In human and animal studies, myocardial ischemia increases serum S100B (Pfeifer et al, 2008; Mazzini et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats

Benetti

Silveira

Matté

et al. 2009

Intl J of Devlp Neuroscience

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We have previously demonstrated that early environment influences the metabolic response, affecting abdominal fat deposition in adult female rats exposed to a long-term highly caloric diet. In the present study, our goal was to verify the effects of the chronic exposure, in adulthood, to a highly palatable diet (chocolate) on cerebral Na+,K+-ATPase activity and S100B protein concentrations, and the response to its withdrawal in neonatally handled and non-handled rats. We measured the consumption of foods (standard lab chow and chocolate), body weight gain, S100B protein concentrations, as well as cerebral Na(+),K(+)-ATPase activity during chronic exposure and after chocolate withdrawal in adult female rats that had been exposed or not to neonatal handling (10 min/day, 10 first days of life). Non-handled rats chronically exposed to chocolate exhibited increased plasma S100B levels, but there was no difference in abdominal fat S100B concentration between groups. Chronic chocolate consumption decreased Na+,K+-ATPase activity in both amygdala and hippocampus in non-handled, but not in handled rats, and this effect disappeared after chocolate withdrawal. Non-handled animals also demonstrated increased frequency of head shaking in the open field after 24h of chocolate withdrawal in comparison to handled ones. These findings suggest that neonatal handling modifies the vulnerability to metabolic and brain alterations induced by chronic exposure to a highly palatable diet in adulthood.

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Diagnostik und Prognostik von Bewusstseinsstörungen und Enzephalopathien

Hansen

Jansen

Cnyrim

et al. 2013

Bewusstseinsstörungen Und Enzephalopathien

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Serum concentration of NSE and S-100b during LVAD in non-resuscitated patients

Cited by 28 publications

References 29 publications

Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats

Diagnostik und Prognostik von Bewusstseinsstörungen und Enzephalopathien

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Serum concentration of NSE and S-100b during LVAD in non-resuscitated patients

Cited by 28 publications

References 29 publications

Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na+,K+‐ATPase and plasma S100B in neonatally handled rats

Diagnostik und Prognostik von Bewusstseinsstörungen und Enzephalopathien

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Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats