Serum concentration of interleukin 10, anti-mannan Candida antibodies and the fungal colonization of the gastrointestinal tract in patients with ulcerative colitis

Ksiądzyna, Dorota; J, Semianów-Wejchert; Nawrot, Urszula; Włodarczyk, Katarzyna; Paradowski, Leszek

doi:10.2478/v10039-009-0023-6

Cited by 21 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, large amounts of Candida sp. can also be detected in the feces or intestinal mucosa among UC patients , and the clinical symptoms and intestinal inflammation may be improved after antifungal treatment. Although fungi represent only a very small fraction of the human gastrointestinal tract microbiota and even though there is limited information available about the prevalence and classification of the intestinal fungal microbiota, one study reported significant differences in fungal communities related to IBD compared to non‐IBD controls .…”

Section: Other Microbial Communities In the Gastrointestinal Tractmentioning

confidence: 99%

The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review

López

Grande

Galvez

et al. 2016

APMIS

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) includes a spectrum of diseases from ulcerative colitis (UC) to Crohn's disease (CD). Many studies have addressed the changes in the microbiota of individuals affected by UC and CD. A decrease in biodiversity and depletion of the phyla Bacteroidetes and Firmicutes has been reported, among others. Changes in microbial composition also result in changes in the metabolites generated in the gut from microbial activity that may involve the amount of butyrate and other metabolites such as H S being produced. Other factors such as diet, age, or medication need to be taken into consideration when studying dysbiosis associated with IBD. Diverse bacterial species have been associated specifically or non-specifically to IBD, but none of them have been demonstrated to be its ethiological agent. Recent studies also suggest that micro-eukaryotic populations may also be altered in IBD patients. Last, but not least, viruses, and specially bacteriophages, can play a role in controlling microbial populations in the gastrointestinal tract. This may affect both bacterial diversity and metabolism, but possible implications for IBD still remain to be solved. Dysbiosis in the oral microbiome associated with IBD remains an emerging field for future research.

show abstract

Section: Other Microbial Communities In the Gastrointestinal Tractmentioning

confidence: 99%

The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review

López

Grande

Galvez

et al. 2016

APMIS

View full text Add to dashboard Cite

show abstract

“…Patients with ulcerative colitis (UC), another form of IBD, are also frequently colonized by Candida [33,34]. For example, in one study, many patients with long standing disease (duration >5 yr) had high level colonization detected in stool or brush smears from inflamed mucosa (Table 1)[34].…”

Section: Candida Colonization Is Associated With Diseases Of the Gi Tmentioning

confidence: 99%

Inflammation and gastrointestinal Candida colonization

Kumamoto

2011

Current Opinion in Microbiology

214

153

View full text Add to dashboard Cite

SUMMARY Candida organisms commonly colonize the human gastrointestinal tract as a component of the resident microbiota. Their presence is generally benign. Recent studies, however, show that high level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization. These effects may create a vicious cycle in which low-level inflammation promotes fungal colonization and fungal colonization promotes further inflammation. Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation. Because Candida is a frequent colonizer, these effects have the potential to impact many people.

show abstract

“…Candida gut overgrowth has been associated with a number of diseases such as diabetes, hematologic malignancies, Crohn's disease and graft vs. host disease and populations such as hospital inpatients and extremely low birth weight infants (TABLE II). Patients with gastrointestinal disorders such as ulcerative colitis and Crohn's disease are more frequently and heavily colonized by C. albicans than are control groups (Ksiadzyna et al 2009, Standaert-Vitse et al 2009). …”

Section: The Gut Mycobiome In Healthy and Diseased Statesmentioning

confidence: 99%

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

2015

View full text Add to dashboard Cite

Abstract:We have entered the Age of the Microbiome, with new studies appearing constantly and whole journals devoted to the human microbiome. While bacteria outnumber other gut microbes by orders of magnitude, eukaryotes are consistently found in the human gut and are represented primarily by the fungi. Compiling 36 studies 1917-2015 we found at least 267 distinct fungal taxa have been reported from the human gut, and seemingly every new study includes one or more fungi not previously described from this niche. This diversity, while impressive, is illusory. If we examine gut fungi, we will quickly observe a division between a small number of commonly detected species (Candida yeasts, Saccharomyces and yeasts in the Dipodascaceae, and Malassezia species) and a long tail of taxa that have been reported only once. Furthermore, an investigation into the ecology of these rare species reveals that many of them are incapable of colonization or long-term persistence in the gut. This paper examines what we know and have yet to learn about the fungal component of the gut microbiome, or "mycobiome", and an overview of methods. We address the potential of the field while introducing some caveats and argue for the necessity of including mycologists in mycobiome studies.

show abstract

Serum concentration of interleukin 10, anti-mannan Candida antibodies and the fungal colonization of the gastrointestinal tract in patients with ulcerative colitis

Cited by 21 publications

References 29 publications

The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review

The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review

Inflammation and gastrointestinal Candida colonization

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

Contact Info

Product

Resources

About