Serum Concentration of D-Dimers as a Marker of the Activation of the Fibrinolytic System in Patients Undergoing Bronchoscopic and Thoracoscopic Investigations

Abstract

Background: Hypercoagulability is common even after minimally invasive surgical techniques and is pathogenetically linked to postoperative thrombotic and cardiac complications. The activation of the coagulation and fibrinolytic systems after bronchoscopic and thoracoscopic investigations has not yet been elucidated. Objective: The aim of our study was to evaluate whether bronchoscopic and thoracoscopic investigations activate the fibrinolytic system. Methods: This study assessed cross-linked fibrinogen degradation products (D-dimer) in 120 patients after bronchoscopy with and without biopsies and/or bronchoalveolar lavage and after thoracoscopy with biopsies of the parietal pleura. Results: Both bronchoscopy and thoracoscopy induced a minor but significant increase in D-dimers in most patients, reversible mostly within 24 h. In rare cases, distinct increases lasting at least 24 h occurred. Conclusions: The slight and temporary increase in serum D-dimers induced by bronchoscopy and thoracoscopy is nonsignificant in most patients; however, in some cases, the coagulation/fibrinolytic systems may become markedly activated.

Coagulopathy and Venous Thromboembolic Events Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

“…Furthermore, the risks are considered to be higher for patients with predisposing conditions, as well as comorbidity and lifestyle, including high BMI and the use of tobacco. 29,30 Mean Using the classification of thrombotic risk factors in cancer patients by Falanga et al, 28 our results failed to show that patient-related factors were related to a significant risk for VTE within 6 months of CRS and HIPEC (Table 3). Although it is well known that the risk of VTE is increased approximately threefold for patients with IBD, 31 none of the 4% of IBD patients in this study (n = 16) developed VTE within 6 months postoperatively.…”

Coagulopathy and Venous Thromboembolic Events Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

“…Furthermore, the risks are considered to be higher for patients with predisposing conditions, as well as comorbidity and lifestyle, including high BMI and the use of tobacco. 29,30 Using the classification of thrombotic risk factors in cancer patients by Falanga et al, 28 our results failed to show that patient-related factors were related to a significant risk for VTE within 6 months of CRS and HIPEC (Table 3). Although it is well known that the risk of VTE is increased approximately threefold for patients with IBD, 31 none of the 4% of IBD patients in this study (n = 16) developed VTE within 6 months postoperatively.…”