Serum concentration and skin tissue expression of insulin‐like growth factor 2 in canine generalized demodicosis

Yarım, Gül Fatma; Yağci, Buğrahan Bekir; Yarım, Murat; Sözmen, Mahmut; Pekmezci, Didem; Çenesiz, Sena; Pekmezci, Gökmen Zafer; Karaca, Efe

doi:10.1111/vde.12270

Cited by 7 publications

(11 citation statements)

References 21 publications

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“…Acne patients who show insulin resistance may have a higher tendency towards Demodex infestation. Yarim et al [ 54 ] demonstrated that serum concentration and skin tissue expression of insulin-like growth factor 2 (IGF-2) increased in canine generalised demodicosis. The IGF-2 levels are high in acne patients as well.…”

Section: Discussionmentioning

confidence: 99%

Demodex spp. as a possible aetiopathogenic factor of acne and relation with acne severity and type

Akçınar¹,

Ünal²,

Al³

2018

pdia

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IntroductionAcne is a very common skin disease in adolescents and young adults, but it also affects adults. However, its aetiology is not yet fully understood. Demodex appears to be associated with multiple skin disorders, but controversy persists. Some reports indicate a connection between acne vulgaris and demodicosis.AimTo confirm the association between Demodex infestation and acne vulgaris.Material and methodsA total of 108 patients were enrolled in the acne group. Acne severity was calculated as GASS and acne type (adolescent and post adolescent) was recorded. An age-sex matched healthy control group comprising 65 individuals were included in the study. Dermatological examinations were performed and an SSSB was used to determine the presence of Demodex.ResultsIn our study, Demodex positivity was seen in 46 (42.6%) patients in the acne group and 8 (12.3%) in the control group; this difference was statistically significant (p < 0.001). A multivariate Backward Step-By-Step Logistic Regression analysis identified the most effective factors for acne development such as Demodex positivity (OR = 5.565, 95% CI: 2.384–12.99 and p < 0.001) and age under 25 years (OR = 2.3 and 95% CI: 1.183–4.473 and p = 0.014). Alcohol consumption was related to Demodex positivity (p = 0.019) in post adolescent acne.ConclusionsOur study is the first one to evaluate acne severity, acne type and the relationship to Demodex prevalence. We suggest that Demodex infestation should be considered when the classical therapies are ineffective especially in cases of post adolescent acne.

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Section: Discussionmentioning

confidence: 99%

Demodex spp. as a possible aetiopathogenic factor of acne and relation with acne severity and type

Akçınar¹,

Ünal²,

Al³

2018

pdia

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“…en animales con demodicosis generalizada crónica se ha encontrado un aumento en la circulación del TGF-β, el cual podría explicar el paso de la enfermedad de una etapa localizada a una generalizada. Asimismo, en estos animales se ha encontrado un aumento en la producción de TGF-α, citoquina que no presenta un efecto inmunosupresor como la TGF-β, pero que puede desplegar la respuesta inflamatoria y provocar daño a nivel tisular; esta acción podría explicar, en parte, los signos clínicos encontrados en la demodicosis (3,11,18,19). También, se ha observado en perros con demodicosis recurrente un aumento en los niveles séricos de Il-10; esta molécula es esencial en la inhibición de la síntesis de citoquinas de las células Th1, lo cual deriva en una supresión de células T; además, esta supresión afecta la capacidad de presentación de antígenos por las células presentadoras de antígenos.…”

Section: Hipótesis De Inmunosupresión Regulada Por Citoquinasunclassified

“…También, se ha observado en perros con demodicosis recurrente un aumento en los niveles séricos de Il-10; esta molécula es esencial en la inhibición de la síntesis de citoquinas de las células Th1, lo cual deriva en una supresión de células T; además, esta supresión afecta la capacidad de presentación de antígenos por las células presentadoras de antígenos. los cambios en los niveles de ciertas citoquinas e interleucinas durante la demodicosis generalizada pueden explicar la aparición de la enfermedad y los hallazgos clínicos encontrados en esta (3,11,18,19).…”

Section: Hipótesis De Inmunosupresión Regulada Por Citoquinasunclassified

“…los receptores tipo Toll (Tlrs) son proteínas transmembranales encontradas en la membrana de las células y en algunos organelos; su función principal es activar la inflamación e inducir una respuesta adaptativa por medio del reconocimiento de ciertas estructuras bacterianas, virales y parasitarias (18). en los últimos años estos receptores han ganado una atención especial debido a su importancia en la lucha contra enfermedades parasitarias, y en dermatología veterinaria estas proteínas son estudiadas buscando una relación especial con el inicio, desarrollo y mantenimiento de la demodicosis en perros.…”

Section: F Hipótesis Del Efecto En Los Receptores Tipo Tollunclassified

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Principales hipótesis inmunológicas de la demodicosis canina

2018

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La demodicosis canina es una enfermedad dermatológica común en perros; se presenta por un aumento en la proliferación de los ácaros del género Demodex spp., pero, a pesar de su alta prevalencia, su aparición y desarrollo son aún desconocidos, sin embargo, se asocian, principalmente, a una inmunodisfunción. El sistema inmune juega un papel importante tanto en el control del ácaro en animales sanos como en el desarrollo de la enfermedad en enfermos; en estos últimos se desconocen los mecanismos inmunitarios que llevan al desbalance en el sistema innato y adaptativo y a la evasión del sistema inmune por el ácaro; debido a esto se han postulado hipótesis que, en conjunto, tratan de explicar los posibles mecanismos inmunológicos. El presente artículo revisa las principales hipótesis inmunológicas relacionadas con la presentación de demodicosis en perros.

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“…A number of studies involving the immunopathogenic mechanisms of demodicosis have been performed and although there is no evidence of any abnormalities related to nonspecific or humoral immunity, functional immunodeficiency was observed in T lymphocytes [7,18]. Furthermore, the role of proinflammatory and immunosuppressive cytokines in modulating the immune response of demodicosis has been investigated and the results demonstrate the active participation of these proteins in recruitment and activation, as well as the suppression, of host immune system cells [11,[19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immuno-Pathology Aspects of Canine Demodicosis

Sousa¹,

Gasparetto²,

Almeida³

2020

Parasitology and Microbiology Research

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Canine demodicosis is a common and often severe dermatopathy of dogs. It is caused mainly by Demodex canis, a parasitic mite of the skin of dogs of the genus Demodex, of the order Acarina and family Demodecidae. This study is aimed to review the clinical-pathological presentation of canine demodicosis and the cytokine-mediated immune response to the cutaneous density of the mite. Only dogs with a defective immune response will present the disease, whether localised or generalised. Microscopically, the dermal inflammatory response is similar among dogs. Localised and generalised demodicosis and pyoderma associated with a high cutaneous density of mites are factors associated with aggravation of lesions in both forms of disease presentation. In addition, the participation of cytokines has been investigated in the induction of the immune response in the different forms of the disease. Although different research groups have invested in studies aimed at elucidating the canine demodicosis pathogenesis, there is still insufficient data to understand the important role of the host immune system in triggering clinical signs and the reproductive management is still an effective preventive method for disease perpetuation.

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Serum concentration and skin tissue expression of insulin‐like growth factor 2 in canine generalized demodicosis

Abstract: These findings indicate that keratinocytes, histiocytes and fibrocytes in the dermis are positive for IGF-2; they may be a source of the elevated serum IGF-2 levels in dogs with generalized demodicosis.

Cited by 7 publications

References 21 publications

Demodex spp. as a possible aetiopathogenic factor of acne and relation with acne severity and type

Demodex spp. as a possible aetiopathogenic factor of acne and relation with acne severity and type

Principales hipótesis inmunológicas de la demodicosis canina

Clinical and Immuno-Pathology Aspects of Canine Demodicosis

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