2022
DOI: 10.4103/jfmpc.jfmpc_960_21
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Serum complements and immunoglobulin profiles in systemic lupus erythematosus patients: An observational study at a teaching hospital

Abstract: Context: Serum complement proteins and autoantibodies play an important role in the pathogenesis and diagnosis of systemic lupus erythematosus (SLE). Abnormalities in various immunoglobulin levels are described in patients of SLE. Aims: To study the spectrum of clinical manifestations and measure the serum levels of complement C3, complement C4, autoantibodies and immunoglobulin G (IgG) in patients of SLE and compare with healthy controls. Settings and De… Show more

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Cited by 3 publications
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“…C3 and C4 levels were negatively associated with SLE disease activity index. This was in accordance with Rana et al [18] Weinstei et al [19] The BECN1 expression was substantially increased in SLE group contrasted to control group. Using the ROC curve, 1.15 was set as cutoff value for detection of beclin1 relative gene expression with 90% sensitivity and 83% specificity.…”
Section: Discussionsupporting
confidence: 91%
“…C3 and C4 levels were negatively associated with SLE disease activity index. This was in accordance with Rana et al [18] Weinstei et al [19] The BECN1 expression was substantially increased in SLE group contrasted to control group. Using the ROC curve, 1.15 was set as cutoff value for detection of beclin1 relative gene expression with 90% sensitivity and 83% specificity.…”
Section: Discussionsupporting
confidence: 91%