Serum cobalt in children with essential hypertension

Nicoloff, G.; Angelova, Maia; Christova, Iva; Николов, А; Alexiev, A. A.

doi:10.1002/ajhb.20554

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…The literature on Co levels in children includes studies on this element’s status in children with iron deficiency anemia [ 31 ], severe malnutrition [ 32 ], and hypertension [ 33 ]. In the available literature, we found one study, which was already mentioned, on the serum and urine Co balance in four adult patients receiving PN.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition

Romanowska,

Wilk,

Danko

et al. 2024

Nutrients

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This study continues the research in which we determined the concentration of aluminum in children receiving long-term parenteral nutrition (LPN). Since our results were interesting, we decided to assay arsenic (As) and cobalt (Co) in the collected material, which, like aluminum, constitute contamination in the mixtures used in parenteral nutrition. Excesses of these trace elements in the human body are highly toxic, and deficiencies, particularly in the case of Co, can lead to various complications. The aim of this study was to determine the impact of LPN in children on their serum levels of As and Co, as well as the excretion of these elements in urine, and to compare them with a control group of healthy children. The study group consisted of 83 children receiving home parenteral nutrition from two Polish centers, while the control group included 121 healthy children. In both groups, the levels of As and Co in serum and urine were measured. The elemental compositions of the samples were determined using inductively coupled plasma mass spectrometry (ICP-MS). It was demonstrated that the children receiving LPN did not have increased As exposure compared to the controls. Greater exposure compared to the control group was shown for Co. In conclusion, children receiving LPN are not exposed to As, and even though the concentrations of Co in serum and urine were higher in the LPN group than in the healthy controls, neither trace element poses a health threat to children requiring LPN.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition

Romanowska,

Wilk,

Danko

et al. 2024

Nutrients

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“…1,2022 cardiovascular diseases 20 metabolism in humans. A study on children with essential HTN showed significantly higher systolic and diastolic blood pressure and significantly lower serum cobalt concentrations than controls [49]. Oxidative stress, inflammation, and apoptosis are pathologic mechanisms in rats' CoCl2 induced HTN and cardiovascular complications [50].…”

Section: Variation Of Serum Trace Element Levels Inmentioning

confidence: 99%

Variation of Serum Trace Element Levels in Patients with Hypertension, Acute Coronary Syndrome and Heart Failure: A Pilot Study

et al. 2022

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Cardiovascular diseases (CVD) contribute to significant mortality and morbidity where trace elements can affect the pathogenesis of CVD. We did a case-control study at the Teaching Hospital, Peradeniya, from January 2017 to August 2017. A trained interviewer was used to collect the patient information and the blood samples; analysis was carried out at the Geochemical Laboratory, Faculty of Science, the University of Peradeniya. Seventy-six individuals were included in the study consisting of 21 hypertension (HTN), 11 acute coronary syndromes (ACS), 20 heart failure (HF), and 24 controls. In HTN patients, Cu, Cd, and Pb showed a high serum level, and V, Cr, Mn, Fe, Ni, Zn, Sr, Ba, and Tl showed a low serum level compared to the control group (p<0.050). In ACS patients Al, As, Cd, and Tl showed a high serum level, and V, Mn, Fe, Zn, Rb, Sr, and Ba showed a low serum level compared to the control group (p<0.050). In HF patients Al, As, Cd, and Tl showed a significantly high serum level, and V, Mn, Zn, Sr, Ba, and Pb, showed a low serum level compared to the control group (p<0.050). Multivariate apportionment of the elements using cluster analyses showed mutual solid clusters among different elements considering patient groups separately. This study concludes that elements in the human body show a heterogeneous variation throughout CVD. Further large-scale studies are vital to establishing the cause-and-effect relationship of these elements to CVD.

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“…Nicoloff et al [12] determined serum cobalt concentrations in children with hypertension. Cobalt is known to be associated with hypertension in adults.…”

Section: Identification Of Causementioning

confidence: 99%

Evaluation of hypertension by the general pediatrician

Nguyen

Mitsnefes²

2007

Current Opinion in Pediatrics

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Current knowledge emphasizes the need to diagnose and treat hypertension when it develops in childhood to decrease the risk of cardiovascular morbidity in adulthood. End-organ injury is evident, illustrated by the presence of left ventricular hypertrophy, even in young children. Assessment for the presence of comorbidities and end-organ damage should be emphasized. Further study is needed to isolate the etiologic factors for childhood hypertension, improve evaluation techniques, and determine if end-organ damage is reversible with proper therapy.

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Serum cobalt in children with essential hypertension

Cited by 11 publications

References 41 publications

Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition

Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition

Variation of Serum Trace Element Levels in Patients with Hypertension, Acute Coronary Syndrome and Heart Failure: A Pilot Study

Evaluation of hypertension by the general pediatrician

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