Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population

Wuthisuthimethawee, Prasit; Saeheng, Sakchai; Oearsakul, Thakul

doi:10.1007/s00068-013-0263-9

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…1 Wuthisuthimethawee et al reported the mean age in their study as 34.9 AE 15.6 years (range: 15-74), focusing on minor head trauma. 13 In another study by Zemlan et al (1999), mean age was 32.4 AE 14.1 years. 12 These are studies from various geographic regions of the world, and all of them reflect that TBI is more often seen in the most productive age group that comprise a larger part of population and directly have an impact on economy of countries, as they are more involved and exposed to the daily outdoor activities.…”

Section: Discussionmentioning

confidence: 91%

“…17 No serum cleaved tau protein could be detected by Wuthisuthimethawee et al in 2013 in either the healthy control group or the patients with mild TBI. 13 They concluded that there was no correlation of serum cleaved tau level in mild TBI, thus making it an unreliable marker in early detection and decision making in mild TBI injury patients at the emergency department. Thus, an increase in serum C-tau levels occurring after mild head trauma does not signify it to the tune of diagnostic significance.…”

Section: Discussionmentioning

confidence: 99%

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“Cleaved Tau Protein”: A Novel Biomarker Candidate in Mild Neurotrauma in Emergency Settings

Pandey

Singh

Pandey³

et al. 2017

IJNT

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Background Neurotrauma has been labeled as a “silent epidemic” affecting both the developed and the developing nations. Traumatic brain injury (TBI) in humans leads to the proteolytic cleavage of tau protein called cleaved tau (C-tau) protein. The objectives of the study are to the role of serum cleaved tau (C-tau/τC) protein as a biomarker in patients with mild TBI and correlate it with the clinical progression (GCS) and clinical outcome (GOS) in emergency settings. Materials and Methods The study has been approved by the institutional ethical committee. The study included 40 cases with mild TBI and 40 controls. C-tau protein levels were measured in venous samples in emergency using human cleaved microtubule-associated protein tau ELISA kit (by CUSABIO). Results The mean serum C-tau protein level in cases was 44.76 ± 23.10 pg/mL (range: 12.32–96.44, 95% CI: 37.37–52.15) and controls was 33.82 ± 13.65 pg/mL, (range: 2.48–66.54, 95% CI: 29.46–38.19, p = 0.091). At admission the mean serum C-tau level was 65.15 ± 22.41, 43.87 ± 9.67, 26.15 ± 9.13 pg/mL in patients with GCS 13, 14, and 15, respectively. Serum cleaved tau protein levels in the good outcome group were significantly lower, that is, 40.77 ± 19.63 pg/mL (mean ± SD) (range: 12.32–88.71, 95% CI: 34.13–47.42) compared with the poor-outcome group 80.66 ± 23.10 pg/mL (mean ± SD) (range: 46.55–96.44, 95% CI: 43.88–117.43, p = 0.004). Conclusion In this study, serum C-tau levels in patients with mild TBI were comparatively higher than those in the controls. Reaching a definitive conclusion will be too early and beyond the scope of this study. Thus, more studies are required in identifying its role as a diagnostic and prognostic marker in mild TBI.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

“Cleaved Tau Protein”: A Novel Biomarker Candidate in Mild Neurotrauma in Emergency Settings

Pandey

Singh

Pandey³

et al. 2017

IJNT

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“…4 Several biomarkers have been developed to directly determine the pathology of the nerve cells in the central nervous system (CNS) when it is injured. 5 The blood-brain barrier (BBB), which normally is almost impermeable, can lose its integrity upon brain injury and allow the permeation of molecules into the blood. 6 A number of patients who suffer from mild head injury later on develop significant disabilities.…”

Section: Introductionmentioning

confidence: 99%

Glial Fibrillary Acidic Protein (GFAP) and Cleaved Tau Protein (CTP) Biomarkers as a Forensic Tool for Detection and Assessement of Traumatic Brain Injury

Mohamed¹,

Elsalam²,

Elzohairy³

et al. 2021

IJFMT

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Traumatic brain injury (TBI) is defined as a traumatically-induced structural brain injury or physiological disruption of brain function caused by an external force. Traumatic brain injury is a neuropsychiatric disorder that breaks down the remaining barriers between neurology and psychiatry. Several biomarkers have been developed to directly determine the pathology of the nerve cells in the central nervous system (CNS) when it is injured. This review recent research on brain injury biomarkers could be used for rapid and accurate diagnostics of TBI in easily accessible fluid. Objectives:The purpose of this study was to assess utility of GFAP-BDP for the diagnosis of intracranial injury in patients with a positive clinical screen for head injury across the spectrum of TBI typically presenting to ED in Kasr-Alainy hospital. Subjects & Methods:This prospective cohort study was based on the data collected from 90 cases presented to Kasr Al-Aini Hospitals Emergency Department, Cairo University, with history of traumatic brain injury through the period from April 2017 to Mars 2019. According to age, they were classified into 3 age groups; age group A (18-35 years), age group B (36-50 years) and age group C (> 50 years). Data were analyzed with respect to socio-demographic data, type of head injury, clinical presentations, radiological investigation, and management of TBI in relation to serum specific biomarkers level (GFAP, C-tau). Results:The most common age group was age group B (18-35 years) (70%). Males were more common than females (71.1% and 28.9% respectively). The most common cause of trauma was fall from height (33.3%). Serum GFAP level and C-tau levels in studied groups show high significant correlation between them (p value <0.001). Conclusion and Recommendations:The combination of the two biomarkers or more may be more useful than either biomarker in isolation for predicting intracranial lesions on CT scanning therefor decreases unwanted CT head scanning and radiological bad effect especially in young ages.

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Tau protein, biomarker for traumatic brain injury

Tovar

2020

Biomarkers for Traumatic Brain Injury

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Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population

Abstract: As it was uncorrelated with traumatic MHI, serum cleaved tau protein proved to be an unreliable biomarker to use in the early detection of and decision-making for traumatic MHI patients at the emergency department.

Cited by 3 publications

References 26 publications

“Cleaved Tau Protein”: A Novel Biomarker Candidate in Mild Neurotrauma in Emergency Settings

“Cleaved Tau Protein”: A Novel Biomarker Candidate in Mild Neurotrauma in Emergency Settings

Glial Fibrillary Acidic Protein (GFAP) and Cleaved Tau Protein (CTP) Biomarkers as a Forensic Tool for Detection and Assessement of Traumatic Brain Injury

Tau protein, biomarker for traumatic brain injury

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