Serum cholinesterase as diagnostic marker of liver disease

Gokani, Ruchi; Jadav, Pranay; Shaikh, Nadeem; Shah, Rita; Chhatriwala, Mitul; Patel, Bhavita

doi:10.7439/ijbar.v5i9.890

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…8,14 The predominant hepatic source of serum cholinesterase, the marked decrease in its synthesis with hepatocyte dysfunction and restoration of synthesis with hepatocyte recovery suggests that serum cholinesterase activity might be a more specific indicator of liver dysfunction than the traditional liver function tests. 15 Despite all the studies, this simple biochemical test is not routinely done as a liver function test worldwide.…”

Section: Articlementioning

confidence: 99%

“…It is essential for the degradation of acetylcholine, after impulse transmission has been mediated. 7,8 The sensitivity and specificity of serum cholinesterase were estimated about 90% and 100% respectively by Gokani et al 8 and they conclude that it must be added as a routine diagnostic test beside other liver function tests for investigation of liver dysfunction. The estimation of serum cholinesterase reflects hepatocellular damage and is regarded as a sensitive indicator of liver diseases.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Amin

El-Shahat

El-Garem

et al. 2017

Gastroenterol Insights

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Section: Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Amin

El-Shahat

El-Garem

et al. 2017

Gastroenterol Insights

View full text Add to dashboard Cite

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Sexually Dimorphic Response to Hepatic Injury in Newborn Suffering from Intrauterine Growth Restriction

Wei,

Tang,

Mao

et al. 2024

Advanced Science

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Intrauterine growth restriction (IUGR), when a fetus does not grow as expected, is associated with a reduction in hepatic functionality and a higher risk for chronic liver disease in adulthood. Utilizing early developmental plasticity to reverse the outcome of poor fetal programming remains an unexplored area. Focusing on the biochemical profiles of neonates and previous transcriptome findings, piglets from the same fetus are selected as models for studying IUGR. The cellular landscape of the liver is created by scRNA‐seq to reveal sex‐dependent patterns in IUGR‐induced hepatic injury. One week after birth, IUGR piglets experience hypoxic stress. IUGR females exhibit fibroblast‐driven T cell conversion into an immune‐adapted phenotype, which effectively alleviates inflammation and fosters hepatic regeneration. In contrast, males experience even more severe hepatic injury. Prolonged inflammation due to disrupted lipid metabolism hinders intercellular communication among non‐immune cells, which ultimately impairs liver regeneration even into adulthood. Additionally, Apolipoprotein A4 (APOA4) is explored as a novel biomarker by reducing hepatic triglyceride deposition as a protective response against hypoxia in IUGR males. PPARα activation can mitigate hepatic damage and meanwhile restore over‐expressed APOA4 to normal in IUGR males. The pioneering study offers valuable insights into the sexually dimorphic responses to hepatic injury during IUGR.

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Protective effect of Tritone (Livosone) on oxidative DNA damage and its hepatoprotective potential against various hepatotoxic agent in wistar rats

Medhekar¹,

Jadhav

Sasane

et al. 2017

Experimental and Toxicologic Pathology

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Serum cholinesterase as diagnostic marker of liver disease

Cited by 3 publications

References 17 publications

Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Sexually Dimorphic Response to Hepatic Injury in Newborn Suffering from Intrauterine Growth Restriction

Protective effect of Tritone (Livosone) on oxidative DNA damage and its hepatoprotective potential against various hepatotoxic agent in wistar rats

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