Serum cholinesterase activity in diabetes and associated pathologies

Lunkes, Gilberto Inácio; Stefanello, Franciele; Lunkes, Daniéle Sausen; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Gonçalves, Jamile Fabbrin

doi:10.1016/j.diabres.2005.08.009

Cited by 30 publications

(23 citation statements)

References 19 publications

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“…In conclusion, BChE activity can be regarded as a biomarker in PD, especially in PD-related dementia. The same function has also been reported in other disorders, including Alzheimer's disease [ 11 ], vascular dementia [ 25 ], ischemic stroke [ 26 ], traumatic brain injury [ 7 ], postoperative delirium [ 27 ], severe trauma [ 28 ], septic shock [ 29 ], burn injuries [ 30 ], adverse cardiac events [ 16 ], hepatic disease [ 17 ], diabetes [ 31 ], and hyperlipidemia [ 32 ]. A former study on AChE levels in PD patients suggested that polymorphisms in ACHE genes fail to initiate ACHE expression, resulting in an impaired Ach/DA balance and subsequent vulnerability of dopaminergic neurons and PD development [ 9 ].…”

Section: Discussionsupporting

confidence: 57%

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Dong

et al. 2017

BioMed Research International

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Objective This study aim to determine changes of serum butyrylcholinesterase (BChE) activity in PD patients and related dementia. Patients and Methods Consecutive PD patients and healthy controls were included and clinical data were collected. Fast serum BChE activity was determined and compared between healthy controls and PD patients. Independent risk factors were performed for BChE activity, PD, and related dementia. The relationship between BChE activity and disease severity was also evaluated. Receiver operating characteristic (ROC) curves were obtained to explore serum BChE activity in distinguishing PD patients and related dementia. Results Serum BChE activity mainly independently correlated with gender, albumin, triglyceride, body mass index, and PD. Serum BChE activity decreased in PD patients compared with healthy controls. Based on the ROC curve, the optimal cut-off point was 6864.08 IU/L for distinguishing PD patients, and the sensitivity and specificity values were 61.8% and 72.1%. It inversely correlated with Unified Parkinson's Disease Rating Scale score. BChE activity decreased in PD-related dementia compared with those without dementia. The sensitivity and specificity values were 70.6% and 76.3%, respectively, with an optimal cut-off point of 6550.00 IU/L. Conclusions Serum BChE activity can be regarded as a biomarker for PD and related dementia.

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Section: Discussionsupporting

confidence: 57%

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Dong

et al. 2017

BioMed Research International

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“…These findings are consistent with those of Estepa and colleagues who reported that higher butyrylcholinesterase activities were observed in pre-pubescent (ages 6-9) obese children (n=46) than in control children (n=49) (Martos Estepa, et al, 2000). Several studies have shown that the enzymatic activity of butyrylcholinesterase is increased in several conditions associated with metabolic syndrome, including obesity, diabetes, and cardiovascular disease (Iwasaki, et al, 2007; Chu, et al, 1978; Inacio Lunkes, et al, 2006; Kutty, et al, 1981; Alcantara, et al, 2005; Annapurna, et al, 1991; Li, et al, 2008). Conversely, decreased butyrylcholinesterase activities have been reported in malnourished humans (Waterlow, 1970).…”

Section: Discussionmentioning

confidence: 99%

Cholinesterase and paraoxonase (PON1) enzyme activities in Mexican–American mothers and children from an agricultural community

González

Huen

Venkat

et al. 2012

J Expo Sci Environ Epidemiol

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Exposure to organophosphate and carbamate pesticides can lead to neurotoxic effects through inhibition of cholinesterase enzymes. The paraoxonase (PON1) enzyme can detoxify oxon derivatives of some organophosphates. Lower PON1, acetylcholinesterase, and butyrylcholinesterase activities have been reported in newborns relative to adults, suggesting increased susceptibility to organophosphate exposure in young children. We determined PON1, acetylcholinesterase, and butyrylcholinesterase activities in Mexican-American mothers and their 9-year-old children (n=202 pairs) living in an agricultural community in California. We used paired t-tests to compare enzymatic activities among mothers and their children and analysis of variance to determine which factors are associated with enzyme activities. Substrate-specific PON1 activities were slightly lower in children than their mothers; however, these differences were not statistically significant. We observed significantly lower acetylcholinesterase but higher butyrylcholinesterase levels in children compared to their mothers. Mean butyrylcholinesterase levels were strongly associated with child obesity status (BMI Z scores >95%). We observed highly significant correlations among mother-child pairs for each of the enzymatic activities analyzed; however, PON1 activities did not correlate with acetylcholinesterase or butyrylcholinesterase activities. Our findings suggest that by age nine, PON1 activities approach adult levels and host factors including sex and obesity may affect key enzymes involved in pesticide metabolism.

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“…This work will further highlight pesticide exposure as a risk for farmers, workers and their families, leading to an easily adopted method that will quantify the environmental exposures providing early detection. Research has also shown links between cholinesterase activity and vascular complications in diabetic patients [ 14 ]. Diabetes is a disease also of increasing concern to the farming and rural population in Australia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Cholinesterase Research Outreach Project (CROP): measuring cholinesterase activity and pesticide use in an agricultural community

2015

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BackgroundAustralian farmers and their workers are exposed to a wide variety of pesticides. Organophosphate (OP) insecticides are a widely used class of pesticide used for animal husbandry practices (Naphthalophos for sheep dipping, jetting and drench), crop production for pest control (Dimethoate) and in public health (Maldison for head lice). Acute poisonings with this class of insecticide are reported among agricultural workers and children around the globe, due to the inhibition of acetylcholinesterase (AChE). Less is known about chronic exposures. Regular monitoring of erythrocyte AChE will enable farmers to identify potential exposure to organophosphate insecticides and take action to reduce exposures and improve their health and safety practices. This study aims to assess and improve the integration of AChE monitoring into routine point of care health clinics, and provide farming and non-farming people with a link between their AChE activity and their household chemical and agrichemical use.Methods/DesignThe research will target individuals who work on mixed farming enterprises and routinely using OPs (n = 50) and non-farmers (n = 30). Baseline data are collected regarding demographic, health conditions and behaviours, Kessler 10 (K10) scores, chemical use and personal protection. Baseline anthropometric measures include height, weight, hip and waist circumference, body fat analysis and, biochemical analysis of fasted total serum cholesterol, triglycerides, low-density cholesterol (LDL), high-density cholesterol (HDL) and blood glucose. Analysis of erythrocyte cholinesterase (EAChE) activity is also conducted using a finger prick test. Testing of EAChE is then repeated in all participants every 3 weeks for a maximum of three times over a period 10 weeks. Participants are provided with full feedback and counselling about their EAChE activity after each reading and a detailed summary provided to all participants at the completion of the study. Data will be analysed using repeated measures within a general linear model.DiscussionThis work will provide an evidence base and recommendations for the integration of EAChE monitoring into Australian rural health clinics, leading to research which will further quantify pesticide exposure both on the farm and in the home, highlighting the importance of sustaining and providing a safe work and home environment for farming communities.Trial registrationACTRN12613001256763

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Serum cholinesterase activity in diabetes and associated pathologies

Cited by 30 publications

References 19 publications

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Cholinesterase and paraoxonase (PON1) enzyme activities in Mexican–American mothers and children from an agricultural community

Cholinesterase Research Outreach Project (CROP): measuring cholinesterase activity and pesticide use in an agricultural community

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