Serum Cholesteryl Ester Transfer Protein (CETP) and Sortilin (SORT) in Patients with Psoriasis with Relation to Systemic Treatment

Nowowiejska, Julia; Baran, Anna; Krahel, Julita A.; Kamiński, Tomasz W.; Maciaszek, Magdalena; Flisiak, Iwona

doi:10.3390/metabo12040340

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…And the results showed that the expression of CETP was different. It was lower in some psoriatic patients, higher in others, and no difference in still others ( 155 ).…”

Section: Cholesterol Metabolism and Psoriatic Inflammationmentioning

confidence: 82%

Crosstalk between cholesterol metabolism and psoriatic inflammation

et al. 2023

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Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities, with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical and clinical studies have revealed that alterations in cholesterol and lipid metabolism are strongly associated with psoriasis. Cytokines (tumor necrosis factor-α (TNF-α), interleukin (IL)-17), which are important in the pathogenesis of psoriasis, have been shown to affect cholesterol and lipid metabolism. Cholesterol metabolites and metabolic enzymes, on the other hand, influence not only the biofunction of keratinocytes (a primary type of cell in the epidermis) in psoriasis, but also the immune response and inflammation. However, the relationship between cholesterol metabolism and psoriasis has not been thoroughly reviewed. This review mainly focuses on cholesterol metabolism disturbances in psoriasis and their crosstalk with psoriatic inflammation.

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“…And the results showed that the expression of CETP was different. It was lower in some psoriatic patients, higher in others, and no difference in still others ( 155 ).…”

Section: Cholesterol Metabolism and Psoriatic Inflammationmentioning

confidence: 82%

Crosstalk between cholesterol metabolism and psoriatic inflammation

et al. 2023

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“…Both are the best models for studying the relationship between lower HDL and psoriasis, so CETP-Tg and PLTP-Tg mice with low HDL were selected as the subjects. CETP is regarded as a marker of liver side effects of acitretin treatment in psoriasis [30]. However, the CETP status in psoriasis may not be clear.…”

Section: Discussionmentioning

confidence: 99%

Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models

Liu

Niu

et al. 2022

Lipids Health Dis

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Background Psoriasis is a chronic inflammatory skin disorder related to dyslipidemia, with decreased high-density lipoprotein (HDL). Various cell types express phospholipid transfer protein (PLTP) as well as cholesteryl ester transfer protein (CETP). Their elevated levels among transgenic (Tg) mice led to reduced HDL and a higher risk of atherosclerosis (AS). This study examined whether elevated CETP and PLTP could aggravate psoriasis in a psoriasis vulgaris mouse model. Methods The back skins of CETP-Tg, PLTP-Tg, and C57BL/6 male mice, aged six to 8 weeks, were shaved for imiquimod cream (IMQ) (5%) treatment for five consecutive days. The clinical pathological parameters were rated independently using the modified target lesion psoriasis severity score. The skin sections stained with hematoxylin-eosin were scored by the Baker score. Epidermal thickening and differentiation and inflammatory factor infiltration were determined by immunohistochemistry. Inflammatory cytokine levels were measured using quantitative reverse transcription-polymerase chain reaction (RT–PCR) and enzyme-linked immunosorbent assay (ELISA) kits. This work employed SPSS Statistics Version to conduct statistical analyses. Results In this study, CETP-Tg and PLTP-Tg mice had higher clinical and histological scores than wild-type (WT) mice. Immunohistochemistry of the epidermis and dermis revealed a high proportion of proliferating cell nuclear antigen (PCNA) positivity within psoriatic skin lesions of CETP-Tg and PLTP-Tg mice compared with WT mice. Interferon-α (IFN-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-17F, IL-22, and IL-23p19 mRNA levels increased within CETP-Tg and PLTP-Tg mice compared with WT counterparts. In comparison with WT mice, plasma tumor necrosis factor-α (TNF-α) levels, rather than IL-6 levels, were increased in CETP-Tg and PLTP-Tg mice. Conclusions Elevated CETP and PLTP aggravate psoriasis in a imiquimod-induced mouse model.

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