Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients

Roy, Alec; Gonzalez, Bienvenido; Marcus, Abir; Berman, J

doi:10.1016/s0165-1781(01)00217-7

Cited by 16 publications

(6 citation statements)

References 24 publications

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“…Additionally, suicide rates were reported to be higher in individuals using drugs. For instance, in research reviewing some 14,000 cases in the USA, it was seen that suicide attempt rates increased in cocaine users [20]. In our study, it was observed that substance use was significantly higher in the case group compared to that in the control group.…”

Section: Resultssupporting

confidence: 53%

An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

Akbaba¹,

Atan²,

Tunçez³

et al. 2021

Int j pharm res allied sci

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Suicide is an important public health issue. In this study, we aimed to review suicide attempt cases by applying a 20-item survey to cases where suicide was attempted and a 15-item survey to the individuals in the control group. After obtaining the required approvals, 200 attempted suicide cases were admitted to the ER between 14.12.2015 and 31.07.2016, and a control group consisting of 198 people was included in the study. Data obtained from the surveys were analyzed using the SPSS program. 132 (66%) of the cases that had attempted suicide were female and 68 (34%) male. The most common age group among those who had attempted suicide was the 12-24 age group with 108 cases (54%). The monthly income, education level, and parental education level of those who had attempted suicide were lower than those in the control group. Approximately two-thirds of the cases were not economically independent, approximately 60% were unmarried, 22% had a fragmented or unstable family environment, more than half smoked or drank alcohol, one-quarter had a history of repeated suicide attempts, 27% had been diagnosed with a psychiatric disease, 32% were using psychiatric drugs and 18% (36 people) had a family history of suicide attempts. Family issues were the reasons most commonly adduced for attempted suicide. The most commonly preferred suicide method (86.5% -173 individuals) was medication overdose. Psycho-sociodemographic profile, reasons for the attempted suicide, and risk factors for suicide have been set out in this study.

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Section: Resultssupporting

confidence: 53%

An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

Akbaba¹,

Atan²,

Tunçez³

et al. 2021

Int j pharm res allied sci

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show abstract

“…Numerous studies showed lower cholesterol levels in patients hospitalized after suicide attempt as compared to non attempters hospitalized patients (Sarchiapone et al, 2001; Guillem et al, 2002; Kim et al, 2002). On the other hand, there are some other studies showing no relationship between low cholesterol levels and suicide attempt (Roy et al, 2001; Tsai et al, 2002; Deisenhammer et al, 2004; Fiedorowizc et al, 2007).…”

Section: Introductionmentioning

confidence: 94%

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa

Marčinko

Nađ

et al. 2009

Acta Neuropsychiatr.

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Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population.Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (N=20) and without suicide attempts (N=20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (p=0.013) and triglyceride levels (p=0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

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“…Nonetheless, many case control studies have found no relationship between cholesterol levels and recent or remote suicide attempts (Fritze et al, 1992;Engstrom et al, 1995;Seefried and Gumpel, 1997;Almeida-Montes et al, 2000;Huang and Wu, 2000;Huang, 2001;Roy et al, 2001;Tsai et al, 2002;Deisenhammer et al, 2004). One recent, large cross-sectional study demonstrated a relationship to elevated cholesterol and suicide attempts in the past year (Brunner et al, 2006) while another demonstrated an association between low high-density lipoprotein cholesterol and increased lifetime suicide attempts in women only (Zhang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Fiedorowicz

Coryell

2007

Psychiatry Research

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Low cholesterol levels have commonly been associated with various suicide measures. We sought to examine suicide attempts in a prospective sample of depressed patients that on prior analysis demonstrated an association between low cholesterol and subsequent suicide completions. Seventyfour inpatients with Research Diagnostic Criteria unipolar major depression, bipolar depression or schizoaffective depression entered a prospective follow-up study from 1978 -1981. Kaplan-Meier survival analysis and Cox regression were utilized to elucidate the relationship between cholesterol levels and subsequent severe suicide attempts as well as all suicide attempts regardless of severity. Attempts preceding index hospitalization and other lifetime attempts were evaluated crosssectionally. Low serum cholesterol levels did not predict subsequent suicide attempts. Contrary to our hypothesis, the high cholesterol group was associated with increased risk of suicide attempts on survival analysis in those less than median age. Nonetheless, in cross-sectional analysis, the low cholesterol group had more suicide attempts preceding index hospitalization and more remote lifetime attempts. The results from this prospective dataset do not support an association between low cholesterol and subsequent suicide attempts despite replicating the retrospective findings of previous case-control and cross-sectional studies.

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Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients

Cited by 16 publications

References 24 publications

An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Cholesterol and suicide attempts: A prospective study of depressed inpatients

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