Serum cholesterol, MTHFR methylation, and symptoms of depression in children.

Mesirow, Maurissa Sydney Chapman; Roberts, Stephen K.; Cecil, Charlotte A.M.; Maughan, Barbara; Jacka, Felice N.; Relton, Caroline L; Barker, Edward D.

doi:10.1037/dev0000831

Cited by 3 publications

(3 citation statements)

References 90 publications

(124 reference statements)

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“…Although P-selectin, thromboglobulin, and MTHFR, a key modulator of purine and thymidylate biosynthesis, play a critical role in thrombosis ( 80 , 81 ), and their alterations have been observed in subjects with depression ( 82 , 83 ), definitive potential relationship with BDNF is actually missing.…”

Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis

Amadio

Macchi

Favero

et al. 2022

Front. Cardiovasc. Med.

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BackgroundObesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs.Research ProcessAssociations among circulating BDNF, depression and EV-derived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score.ResultsBDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-γ. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group.

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Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis

Amadio

Macchi

Favero

et al. 2022

Front. Cardiovasc. Med.

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“…141 In addition, longitudinal studies have found that associations of cholesterol levels between birth and adolescence are associated with the later development of depressive symptoms. [142][143][144]…”

Section: N Kappelmann Et Almentioning

confidence: 99%

“…One longitudinal study found an association between childhood alterations in lipid profiles with psychotic symptoms at age 18 years 141 . In addition, longitudinal studies have found that associations of cholesterol levels between birth and adolescence are associated with the later development of depressive symptoms 142–144 …”

Section: Epidemiologic Evidence For Prenatal and Childhood Infection ...mentioning

confidence: 99%

Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis

Kappelmann

Perry

Khandaker

2022

Harv Rev Psychiatry

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Depression and psychosis have a developmental component to their origin. Epidemiologic evidence, which we synthesize in this nonsystematic review, suggests that early-life infection, inflammation, and metabolic alterations could play a role in the etiology of these psychiatric disorders. The risk of depression and psychosis is associated with prenatal maternal and childhood infections, which could be mediated by impaired neurodevelopment. Evidence suggests linear dose-response associations between elevated concentrations of circulating inflammatory markers in childhood, particularly the inflammatory cytokine interleukin 6, and the risk for depression and psychosis subsequently in early adulthood. Childhood inflammatory markers are also associated with persistence of depressive symptoms subsequently in adolescence and early adulthood. Developmental trajectories reflecting persistently high insulin levels during childhood and adolescence are associated with a higher risk of psychosis in adulthood, whereas increased adiposity during and after puberty is associated with the risk of depression. Together, these findings suggest that higher levels of infection, inflammation, and metabolic alterations commonly seen in people with depression and psychosis could be a cause for, rather than simply a consequence of, these disorders. Therefore, early-life immuno-metabolic alterations, as well as factors influencing these alterations such as adversity or maltreatment, could represent targets for prevention of these psychiatric disorders. Inflammation could also be an important treatment target for depression and psychosis. The field requires further research to examine sensitive periods when exposure to such immuno-metabolic alterations is most harmful. Interventional studies are also needed to test the potential usefulness of targeting early-life immuno-metabolic alterations for preventing adult depression and psychosis.

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Epigenetic Pathways from Dietary Fat to Psychopathology

Ragsdale

2024

Epigenetics and Human Health

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Serum cholesterol, MTHFR methylation, and symptoms of depression in children.

Cited by 3 publications

References 90 publications

Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis

Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis

Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis

Epigenetic Pathways from Dietary Fat to Psychopathology

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