Serum Cholesterol Levels in Neutropenic Patients with Fever

Fraunberger, Peter; Hahn, J.; Holler, Ernst; Walli, Autar K.; Seidel, D.

doi:10.1515/cclm.2002.048

Cited by 17 publications

(11 citation statements)

References 25 publications

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“…Several studies showed that the reduction in cholesterol levels and the alterations in apolipoprotein concentrations were correlated with certain cytokine and acute phase protein levels. Indeed, such correlations were demonstrated in patients with sepsis ( 44 ), in neutropenic patients with fever ( 45 ), and in normal volunteers after a single intravenous endotoxin injection ( 46 ). Moreover, similar associations were noticed in patients with AIDS ( 47 ) and in critically ill surgical patients ( 48 ).…”

Section: Pon1 (Paraoxonase) and Pon1 (Arylesterase) Activitiesmentioning

confidence: 65%

Persistence of an atherogenic lipid profile after treatment of acute infection with brucella

Apostolou

Gazi

Kostoula

et al. 2009

Journal of Lipid Research

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This article is available online at http://www.jlr.org herpes simplex virus, helicobacter pylori, as well as periodontitis have been studied ( 2-4 ). On the contrary, other studies have disputed the causal role of infectious agents in atherogenesis ( 5-7 ).Current evidence suggests that atherosclerosis develops as a response to infl ammatory stimulus. Therefore, common or uncommon infections could represent a risk factor. Mechanisms that may be implicated in the atherogenesis caused by infectious agents include local increase of proinfl ammatory cells, local effusion of endotoxins, autoimmune reaction, systemic cytokine release, and changes in lipid metabolism ( 8 ).Infection and infl ammation cause similar cytokineinduced changes in lipid and lipoprotein metabolism ( 9 ). These include reductions in serum levels of total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apolipoproteins (Apo) AI and B, and lipoprotein (a) [Lp(a)] and increases in triglyceride (TG) and ApoE concentrations ( 9-14 ).Current evidence suggests that the host response to infection and infl ammation increases oxidized lipids in serum and induces LDL oxidation in vivo. Oxidative modifi cation of LDL is an important event in the development of atherosclerosis ( 15 ). In addition, the cholesterol ester transfer protein (CETP) plays a central role in HDL metabolism and the regulation of HDL-C levels in serum. High levels of CETP activity lead to a reduction in HDL-C levels and an atherogenic lipoprotein profi le ( 16 ).Platelet-activating factor (PAF) is a potent pro-infl ammatory phospholipid produced by activated platelets, -C), ApoB, ApoAI, and ApoCIII and higher LDL-C/HDL-C and ApoB/ApoAI ratios; 2 ) higher levels of IL-1b, IL-6, and TNFa; 3 ) similar ApoCII and oxLDL levels and Lp-PLA 2 activity, lower PON1, and higher CETP activity; and 4 ) higher small dense LDL-C concentration. Four months later, increases in TC, HDL-C, LDL-C, ApoB, ApoAI, and ApoCIII levels, ApoB/ApoAI ratio, and PON1 activity were noticed compared with baseline, whereas CETP activity decreased. LDL-C/HDL-C ratio, ApoCII, and oxLDL levels, Lp-PLA 2 activity, and small dense LDL-C concentration were not altered. Brucella infection is associated with an atherogenic lipid profi le that is not fully restored 4 months following treatment. There is increasing evidence that a link exists between infection/infl ammation and atherosclerosis ( 1 ). Infections with chlamydia pneumoniae, cytomegalovirus,

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Section: Pon1 (Paraoxonase) and Pon1 (Arylesterase) Activitiesmentioning

confidence: 65%

Persistence of an atherogenic lipid profile after treatment of acute infection with brucella

Apostolou

Gazi

Kostoula

et al. 2009

Journal of Lipid Research

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“…Allocholic acid and 3-hydroxychola-7, 22-dien-24-oic acid, both of which was in the plasma of pyrexia rats, belong to bile acids and their derivatives that are the metabolites of cholesterol. Previous reports have documented that neutropenic patients with fever showed a significant decrement for the level of serum cholesterol [48], indicating that the decrease bile acids in pyrexia rats might be related to the cholesterol decrease.…”

Section: Discussionmentioning

confidence: 89%

Plasma Metabolomic Profiling to Reveal Antipyretic Mechanism of Shuang-Huang-Lian Injection on Yeast-Induced Pyrexia Rats

Gao

Guo

et al. 2014

PLoS ONE

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Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford a certain anti-febrile action. However, seldom does research concern the pharmacological mechanisms of SHLI. In the current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to reveal the antipyretic mechanism of SHLI on yeast-induced pyrexia rat model using UPLC-Q-TOF/MS coupled with multivariate statistical analysis and pattern recognition techniques. We discovered a significant perturbance of metabolic profile in the plasma of fever rats and obvious reversion in SHLI-administered rats. Eight potential biomarkers, i.e. 1) 3-hydeoxybutyric acid, 2) leucine, 3) 16∶0 LPC, 4) allocholic acid, 5) vitamin B2, 6) Cys-Lys-His, 7) 18∶2 LPC, and 8) 3-hydroxychola-7, 22-dien-24-oic acid, were screened out by OPLS-DA approach. Five potential perturbed metabolic pathways, i.e. 1) valine, leucine, and isoleucine biosynthesis, 2) glycerophospholipid metabolism, 3) ketone bodies synthesis and degradation, 4) bile acid biosynthesis, and 5) riboflavin metabolism, were revealed to relate to the antipyretic mechanisms of SHLI. Overall, we investigated antipyretic mechanisms of SHLI at metabolomic level for the first time, and the obtained results highlights the necessity of adopting metabolomics as a reliable tool for understanding the holism and synergism of Chinese patent drug.

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“…The majority of studies in humans included patients with sepsis [2,25,26]. The majority of studies in humans included patients with sepsis [2,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies by us and others have shown that lipids are altered in patients with various infections. The majority of studies in humans included patients with sepsis [2,25,26]. Other infections were also investigated [1].…”

Section: Discussionmentioning

confidence: 99%