Serum cholesterol in bulimia nervosa

Pauporte, Joelle; Walsh, B. Timothy

doi:10.1002/eat.1087

Cited by 13 publications

(7 citation statements)

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“…However, the serum total cholesterol values in patients with AN in previously published papers were widely distributed (10,11,(17)(18)(19)(20)(21). Although the frequency of cardiac events in patients with BN is not clear, the serum cholesterol values in patients with BN were also widely distributed (22)(23)(24)(25)(26). Small numbers of subjects studied and/or different definitions of hypercholesterolemia in previous reports may account for the different results in the percentages of hypercholesterolemia in these patients.…”

Section: Discussionmentioning

confidence: 86%

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Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

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Objective To evaluate some risk factors for cardiovascular diseases in feeding and eating disorders, the degree of lipid abnormalities was investigated in a large Japanese cohort of different groups of feeding and eating disorders, according to the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012). Methods Participants in the current study included 732 women divided into four groups of feeding and eating disorders: anorexia nervosa, restricting type (AN-R); anorexia nervosa, binge-eating/purging type; bulimia nervosa (BN); and binge-eating disorder (BED). We measured the serum levels of total cholesterol, highdensity-lipoprotein (HDL) cholesterol, and triglyceride in these participants. Low-density-lipoprotein (LDL) cholesterol and non-HDL cholesterol levels were also calculated. Results The concentrations of LDL cholesterol and non-HDL cholesterol were widely distributed in all groups. When the LDL cholesterol risk was defined as ! 120 mg/dL and the non-HDL cholesterol risk as ! 150 mg/dL, according to the JAS Guidelines 2012, the proportion of LDL cholesterol risk ranged from 29.6% (BN) to 38.6% (AN-R), and the proportion of non-HDL cholesterol risk ranged from 17.8% (BN) to 30.1% (BED). Conclusion The present findings suggest the existence of LDL cholesterol risk and non-HDL cholesterol risk in all groups of eating disorders. Given the chronicity of this condition, the development of elevated concentrations of LDL cholesterol and non-HDL cholesterol at an early age may increase the risk of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 86%

“…When the LDL cholesterol risk was defined as ! 120 mg/dL, according to the JAS Guidelines 2012 (25), the proportions of LDL cholesterol risk were 38.6% in AN-R, 31.4% in AN-BP, 29.6% in BN, and 36.4% in BED. No significant group differences were found in the proportion of LDL cholesterol risk.…”

Section: Resultsmentioning

confidence: 99%

Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

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“…Over the last two decades, a leading hypothesis regarding the persistence of this behavior is that individuals with BN have a disturbance in satiation. Evidence supporting this hypothesis includes documentation of the consumption of very large amounts of food during binge meals in laboratory settings2–5 and diminished release of the hormone cholecystokinin (CCK) that normally aids the development of satiation6–8. In addition, during the course of meals during which subjects were asked to binge eat and allowed to consume food ad libitum, individuals with BN reported achieving a maximum level of fullness comparable to that of controls only after the consumption of substantially larger amounts of food9.…”

Section: Introductionmentioning

confidence: 99%

The development of satiation in bulimia nervosa

Zimmerli

Devlin

Kissileff

et al. 2010

Physiology & Behavior

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Bulimia nervosa (BN) is characterized by the recurrent consumption of excessive amounts of food (binge eating) followed by inappropriate compensatory behaviors. A leading hypothesis is that the persistence of BN may be due, in part, to a disturbance in the development of satiation. Because patients with BN consume larger meals than controls, previous studies have not been able to directly compare the development of satiation. In order to address this problem, subjects consumed large meals of predetermined size without knowing when they would be stopped. Twenty-one women with BN and 13 control women participated in a study in which they rated hunger and fullness during the course of a 975 g liquid meal eaten from an opaque reservoir. Subjects’ ratings were obtained after each 75 g increment of consumption. There were no statistically significant differences between the two groups in the mean ratings of hunger or of fullness before, after, or during the meal. Individuals with BN consumed the meal more rapidly than control participants. These results suggest that, when individuals with BN are not instructed to binge eat and do not control meal size, they do not manifest a disturbance in reported satiation over the course of a large liquid meal.

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“…Sometimes the bulimic behavior is present in patients with AN or people whom carry out restrictive diets, but the BN itself does not produce significant weight loss. What may occur due to induced vomiting, are gastrointestinal problems, severe hypokalemia, hypercholesterolemia (Pauporte & Walsh, 2001), hypernatremia (Crow et al, 2001), hypophosphatemia (Winston & Wells, 2002), impairment in renal fluid and electrolyte balance, with changes that can influence heart function (Andersen, 1985), as well as damage to teeth due to the acidity of vomiting (Daee et al, 2002).…”

Section: Introductionmentioning

confidence: 99%