Serum Chemerin in Obese Children and Adolescents Before and After L-Carnitine Therapy: Relation to Nonalcoholic Fatty Liver Disease and Other Features of Metabolic Syndrome

Hamza, Rasha T.; El-Kabbany, Zeinab A.; Shedid, Ahmed M.; Hamed, Amira; Ebrahim, Asmaa

doi:10.1016/j.arcmed.2016.11.010

Cited by 25 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it seems that this adipokine might create a relationship between inflammation and metabolic disorders such as metabolic syndrome, obesity, and obesity‐related comorbidities (Landgraf et al, ). Lifestyle modification and L‐carnitine supplementation can reduce chemerin levels (Hamza, Elkabbany, Shedid, Hamed, & Ebrahim, ; Niklowitz, Rothermel, Lass, Barth, & Reinehr, ). However, the curcumin supplementation effect on chemerin levels in adolescents is not clear.…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Saraf‐Bank

Ahmadi

Paknahad

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Introduction: It is well known that there is a strong linkage between obesity, systemic low-grade inflammation, and oxidative stress in the pediatric population. Possible strategies that might control obesity and its relevant problems in this crucial group are of utmost importance. Therefore, the aim of this study was to evaluate the effects of curcumin supplements on inflammation, oxidative stress, and chemerin levels in adolescent girls.Methods: Totally, 60 overweight and obese adolescent girls were randomly assigned to either placebo or intervention group in a randomized placebocontrolled parallel trial design. Adolescents consumed one 500-mg curcumin or placebo per day along with a slight weight loss diet for 10 weeks. High-sensitive Creactive protein (hs-CRP), interleukin 6 (IL-6), total antioxidant capacity (TAC), malondialdehyde (MDA), chemerin levels, and anthropometric measurements were assessed at the beginning and end of the trial.Results: Curcumin supplementation had a significant effect on IL-6 levels and oxidative stress markers including TAC and MDA in crude model. After controlling the effects of confounders, curcumin supplementation had a substantial effect on inflammation (hs-CRP and IL-6) and oxidative stress (TAC) marker of adolescents.Discussion: Ten weeks of curcumin supplementation had beneficial effects on inflammation and oxidative stress markers among postpubescent overweight and obese girl adolescents.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Saraf‐Bank

Ahmadi

Paknahad

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Chemerin is primarily produced in liver and adipose tissue and exerts important roles in multiple aspects such as adipogenesis, lipolysis, glycolipid metabolism, insulin resistance (IR), inflammation [2], energy metabolism, immunity, and cell proliferation and differentiation [3]. Circulating chemerin is elevated in numerous metabolic and inflammatory diseases including obesity [4], metabolic syndrome [5], type 2 diabetes [6], atherosclerosis [7, 8], hypertension [9], cardiovascular disease [8, 10] and nonalcoholic fatty liver disease [11, 12], and the chemerin level is associated with symptoms severity of these inflammatory diseases [13].…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ

Lin

Yang

et al. 2019

Nutr Metab (Lond)

View full text Add to dashboard Cite

Objective To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism is related to peroxisome proliferator activated receptor γ (PPARγ), a key modulator of glycolipid metabolism. Methods Obesity rats induced by 8-week high fat diet (HFD) were randomly divided into obesity group (OB) and exercised obesity group (EOB) with 8 rats each group, and 40 diabetes rats established by 8-week HFD plus low dose of streptozotocin were randomly divided into 4 groups: diabetes group (DM), exercised diabetes group (EDM), exercised diabetes plus PPARγ agonist pioglitazone group (EDP), and exercised diabetes plus PPARγ antagonist GW9662 group (EDG). The rats in EOB, EDM, EDG and EDP groups participated in a 4-week moderate-intensity aerobic exercise on a treadmill with gradually increasing intensity, once a day and 6 days/week, and 30 min before each exercise EDP and EDG were administrated to the rats in EDP and EDG groups, respectively. Before and after 4-week exercise, glycolipid metabolism indexes, serum chemerin and the levels of chemerin and CMKLR1 in metabolic organs such as liver and gastrocnemius were investigated (not detecting adipose for no available perirenal adipose from DM rats). Results (1) In addition to serum chemerin, the levels of chemerin and CMKLR1 in the liver and gastrocnemius of EOB and EDM rats were declined, accompanied with the improved glycolipid metabolism. (2) The decreased chemerin/CMKLR1 in the EDM rats were reversed by PPARγ antagonist GW9662 and further strengthened by PPARγ agonist pioglitazones. Conclusions Besides serum chemerin, the levels of chemerin/CMKLR1 in the metabolic organs of obesity and diabetes rats were alleviated by exercise, which were likely to be associated with the improvement of glycolipid metabolism. Exercise-induced decrements of chemerin/CMKLR1 in the diabetes rats were mediated by PPARγ. Electronic supplementary material The online version of this article (10.1186/s12986-019-0344-9) contains supplementary material, which is available to authorized users.

show abstract

“…In human plasma chemerin levels were higher in many chronic inflammatory disorders including rheumatoid arthritis, coronary artery disease, obesity, type 2 diabetes, Crohn disease or COPD (chronic obstructive pulmonary disease) [18][19][20][21]. Additionally increased expression of chemerin was found in various inflammatory sites including skin lesion of acute psoriasis, lupus and in kidney tissuein lupus nephritis [18][19][20][21]. In contrast, lower chemerin levels were found in children with anorexia nervosa [22].…”

Section: Discussionmentioning

confidence: 99%

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

Machura¹,

Ziora²,

Szczepańska³

et al. 2017

Pediatr. Endocrinol.

View full text Add to dashboard Cite

Introduction. Patients with cystic fibrosis (CF) present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentration. The aim of the study is to evaluate serum concentration of chemerin, omentin and vaspin in children with cystic fibrosis. Material and Methods. The study group included 21 children (mean age 11.3±0.4 years) with stable CF. The diagnosis of CF was established by sweat test and later confirmed by genetic examination in all subjects. Patients with pulmonary exacerbation were excluded from study. In all children history, physicalexamination, anthropometric parameters, sputum, blood samples, and lung function tests were assessed.The control group consisted of 22 healthy children (mean age 10.9 ±4.4years). Results. The mean serum levels of chemerin and omentin were higher (p<0.001) in CF children than in healthy children. The mean serum vaspin concentration was significantly lower than in controls (p<0.001). Concentrations of examined adipokines showed no correlation with BMI, BMI-SDS, Słowa kluczowe mukowiscydoza, chemeryna, omentyna, waspina, dzieci Streszczenie Wstęp. Pacjenci z mukowiscydozą (cysticfibrosis, CF) prezentują liczne patologiczne stany, jak niedożywienie, zmniejszenie masy tłuszczowej ciała, zaburzenia metaboliczne (zaburzony metabolizm glukozy, wzrost insulinooporności, przewlekły deficyt energii, miejscowe i chroniczne zapalenie), które mogą mieć związek z zaburzeniami stężeń adipokin. Celem badań jest ocena stężenia chemeryny, omentyny i waspiny w surowicy krwi u dzieci z mukowiscydozą. Materiał i metody. Badaniami objęto21 dzieci (średni wiek: 11,7± 1,59 lat) ze stabilną CF. Diagnozę CF u tych dzieci potwierdzono badaniem genetycznym. Pacjentów z zaostrzeniem choroby wykluczono z badań. U wszystkich dzieci przeprowadzono wywiad, badanie fizykalne i antropometryczne, zbadano plwocinę, pobrano krew, wykonano czynnościowe badania płuc. Grupę kontrolną stanowiło 22 zdrowych dzieci (średni wiek: 10,9 ± 4,4 lat). Wyniki. Średnie stężenie chemeryny i omentyny w surowicy krwi było istotnie wyższe (p<0.001), a waspiny znamiennie niższe (p<0,001) u dzieci z mukowiscydozą aniżeli u zdrowych. Nie stwierdzono znamiennych statystycznie korelacji pomiędzy stężeniem badanych adipokin we krwi a BMI, BMI-SDS, glukozą, cholesterolem całkowitym, LDL i HDL we krwi. FEV1 i FVC Praca oryginalna

show abstract

Serum Chemerin in Obese Children and Adolescents Before and After L-Carnitine Therapy: Relation to Nonalcoholic Fatty Liver Disease and Other Features of Metabolic Syndrome

Cited by 25 publications

References 43 publications

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

Contact Info

Product

Resources

About