Serum CCL11 level is associated with radiographic spinal damage in patients with ankylosing spondylitis

Jeong, Hoim; Roh, Jong Seong; Lee, Hanna; Kim, Eunsung; Koh, Jung Hee; Lee, Seung-Geun

doi:10.1007/s00296-018-4073-6

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…However, twin and family studies suggest that HLA-B27 only can explain less than 30% of the overall risk for AS (10,11), meaning there are other genes related with the genetic disorder of AS. Recently, scholars have also aimed to investigate other inflammatory biomarkers for AS, including interleukin ( IL )-8 (12), tumor necrosis factor ( TNF )-α (13), C-reactive protein ( hsCRP ) (14) and C-C motif chemokine 11 ( CCL11 ) (15), but studies that have focused on the genetic biomarkers are limited (16,17).…”

Section: Introductionmentioning

confidence: 99%

Screening of underlying genetic biomarkers for ankylosing spondylitis

Fan

et al. 2019

Mol Med Report

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Genetic biomarkers for the diagnosis of ankylosing spondylitis (AS) remain unreported except for human leukocyte antigen B27 (HLA-B27). Therefore, the aim of the present study was to screen the differentially expressed genes (DEGs), and those that also possess differential single nucleotide polymorphism (SNP) loci in the whole blood of AS patients compared with healthy controls by integrating two mRNA expression profiles (GSE73754 and GSE25101) and SNP microarray data (GSE39428) collected from the Gene Expression Omnibus (GEO). Using the t-test, 1,056 and 1,073 DEGs were identified in the GSE73754 and GSE25101 datasets, respectively. Among them, 234 DEGs were found to be shared in both datasets, which were subsequently overlapped with 122 differential SNPs of genes in the GSE39428 dataset, resulting in identification of two common genes [eukaryotic translation elongation factor 1 epsilon 1 ( EEF1E1 ) and serpin family A member 1 ( SERPINA1 )]. Their expression levels were significantly upregulated and the average expression log R ratios of SNP sites in these genes were significantly higher in AS patients than those in controls. Function enrichment analysis revealed that EEF1E1 was involved in AS by influencing the aminoacyl-tRNA biosynthesis, while SERPINA1 may be associated with AS by participating in platelet degranulation. However, only the genotype and allele frequencies of SNPs (rs7763907 and rs7751386) in EEF1E1 between AS and controls were significantly different between AS and the controls, but not SERPINA1 . These findings suggest that EEF1E1 may be an underlying genetic biomarker for the diagnosis of AS.

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Section: Introductionmentioning

confidence: 99%

Screening of underlying genetic biomarkers for ankylosing spondylitis

Fan

et al. 2019

Mol Med Report

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“…In subsequent studies on the serological level of DKK-1 in patients with AS, some studies ( 17 , 20 , 22 , 24 , 26 – 28 , 44 , 47 , 49 , 51 – 53 , 55 , 56 , 59 , 60 , 62 ) also demonstrated lower serum DKK-1 levels in patients than in controls. In contrast, some studies ( 15 , 16 , 18 , 21 , 23 , 25 , 43 , 45 , 48 – 50 , 57 , 58 , 63 ) have reported that the serum level of DKK-1 in patients was higher than that in controls. Furthermore, there were also some studies ( 19 , 29 , 41 , 42 , 46 , 54 , 61 , 64 , 65 ) showing that there was no significant diversity in DKK-1 serum levels among AS patients and healthy controls.…”

Section: Discussionmentioning

confidence: 84%

“…However, another recent meta-analysis containing 23 studies from 2010-2017 revealed no significant difference in serum DKK-1 concentration between AS patients and healthy controls (14). Furthermore, more recent studies have reported controversial results since 2018 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The reason for the inconsistent results may be due to the potential bias of traditional epidemiology, such as measurement error, reverse causality, confounding bias, different races, and clinical heterogeneity, which are caused by the nature of the study design (31).…”

Section: Introductionmentioning

confidence: 99%

Serum DKK-1 level in ankylosing spondylitis: insights from meta-analysis and Mendelian randomization

et al. 2023

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ObjectiveThe purpose of this study was to precisely evaluate the serum Dickkopf-1 (DKK-1) level in patients with ankylosing spondylitis (AS) relative to that in normal controls and to test the causal relationship between DKK-1 and the risk of AS.MethodsEmbase, PubMed, Web of Science, WANFANG DATA, VIP, and China National Knowledge Infrastructure (CNKI) were comprehensively searched until July 2022 for pertinent studies. The pooled standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated by the fixed or random-effect model. In Mendelian randomization (MR) analysis on the causal relationship between serum DKK-1 level and AS risk, the inverse variance weighting method (IVW), MR-Egger regression, weighted median method, and weighted pattern method were applied. Sensitivity analyses, including the horizontal pleiotropy test, heterogeneity test, and leave-one-out test, were also performed.ResultsThe meta-analysis of 40 studies containing 2,371 AS patients and 1,633 healthy controls showed that there was no significant difference in DKK-1 serum level between AS patients and normal controls (pooled SMD=0.207, 95% CI =−0.418-0.832, P=0.516). The subgroup analysis of the CRP ≤ 10 mg/L group showed that AS patients had higher serum DKK-1 concentration than the healthy controls (SMD=2.267, 95% CI = 0.102-4.432, P=0.040). Similarly, MR analysis also demonstrated no significant association between DKK-1 serum level and AS (IVW OR=0.999, 95% CI = 0.989-1.008, P=0.800). All sensitivity analyses revealed consistent results.ConclusionsThere was no significant change in serum DKK-1 concentration between AS patients and healthy controls. In addition, no causal relationship exists between serum DKK-1 levels and AS risk.

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“…Furthermore, together with its cognate receptor CCR3, CCL11 correlates with disturbed bone remodeling, and stimulates migration of osteoclast precursors and bone resorption [ 117 ]. Although the clinical significance of CCL11 in bone metabolism in AS patients has not been completely investigated, it seems that CCL11 serum levels are significantly positively correlated with mSASSS and syndesmophyte numbers [ 17 ]. Eotaxin-11 is also overexpressed in human atherosclerotic lesions [ 118 ].…”

Section: Molecules Involved In Bone Homeostasismentioning

confidence: 99%

Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

Diaconu

Ceasovschih

Șorodoc

et al. 2022

IJMS

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management.

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Serum CCL11 level is associated with radiographic spinal damage in patients with ankylosing spondylitis

Cited by 9 publications

References 40 publications

Screening of underlying genetic biomarkers for ankylosing spondylitis

Screening of underlying genetic biomarkers for ankylosing spondylitis

Serum DKK-1 level in ankylosing spondylitis: insights from meta-analysis and Mendelian randomization

Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

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