Serum Cathepsin H as a Potential Prognostic Marker in Patients with Colorectal Cancer

Schweiger, Ana; Christensen, Ib Jarle; Nielsen, Hans Jørgen; Sørensen, Steen; Brünner, Nils; Kos, Janko

doi:10.1177/172460080401900406

Cited by 24 publications

(8 citation statements)

References 22 publications

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“…Downregulation of cathepsin H is consistent with other cancers, like cervical cancer 28 and melanoma, where the expression of cathepsin H was inversely related to the invasive potential of the tumor 29. In colorectal cancer high carcinoembryonic antigen (CEA) and low cathepsin H expression correlated with poor prognosis 30. An upregulation of cathepsin H, on the other hand, was found in bladder carcinomas 31 and basal cell carcinomas 32.…”

Section: Discussionsupporting

confidence: 66%

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis

Husmann¹,

Muff²,

Bolander³

et al. 2007

Molecular Carcinogenesis

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Osteosarcoma is the most frequent malignant bone tumor with a poor survival rate for patients with metastasis. Previous studies have shown that beside other proteases, distinct sets of cathepsins are involved in the process of metastasis of different tumors. In this study we investigated the expression of cathepsin proteases in human osteosarcoma metastasis. First, the mRNA expression of 14 human cathepsins was studied in SAOS-2 osteosarcoma cells and the highly metastatic LM5 and LM7 sublines by reverse transcriptase (RT)-polymerase chain reaction (PCR). The expression of cathepsin D, K, and L mRNA was found upregulated and that of cathepsin F, H, and V downregulated in the highly metastatic LM5 and LM7 cells. A subgroup of the cathepsin proteases was further studied at the protein level by Western blot analysis of cell extracts. The expression of cathepsin B and H was decreased and that of cathepsin D, K, and L was increased in the highly metastatic cell lines as compared to the SAOS-2 cell line. Diagnostic relevance of cathepsin K expression in osteosarcoma was revealed upon correlation of survival and metastasis with immunohistochemical cathepsin K staining of biopsies collected from 92 patients prior to chemotherapy. Patients with metastatic high-grade osteosarcoma and low cathepsin K expression at diagnosis had a better prognosis than those with high expression. Thus, it appears that cathepsin K expression is of predictive prognostic value for patients with high-grade tumors and metastasis at diagnosis. ß 2007 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 66%

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis

Husmann¹,

Muff²,

Bolander³

et al. 2007

Molecular Carcinogenesis

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“…Moreover, cathepsin L levels were increased in sera of patients with pancreatic [ 180 ] and liver cancers [ 181 ]. Serum cathepsin H levels were found to be increased in patients with lung [ 182 ], melanoma [ 183 ], and colorectal cancers [ 184 ]. The findings of these recent studies have alluded to a potential of utilizing cathepsins as biomarkers of cancer though few studies show some discrepancies in the outcomes of cathepsin expression and activity during cancer (reviewed in [ 185 ]).…”

Section: Targeting Cathepsins In Disease Managementmentioning

confidence: 99%

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

Yadati

Houben

Bitorina

et al. 2020

Cells

283

198

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Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions. The discovery that cathepsins are secreted and remain functionally active outside of the lysosome has caused a paradigm shift. Contemporary research has unraveled many versatile functions of cathepsins in extralysosomal locations including cytosol and extracellular space. Nevertheless, extracellular cathepsins are majorly upregulated in pathological states and are implicated in a wide range of diseases including cancer and cardiovascular diseases. Taking advantage of the differential expression of the cathepsins during pathological conditions, much research is focused on using cathepsins as diagnostic markers and therapeutic targets. A tailored therapeutic approach using selective cathepsin inhibitors is constantly emerging to be safe and efficient. Moreover, recent development of proteomic-based approaches for the identification of novel physiological substrates offers a major opportunity to understand the mechanism of cathepsin action. In this review, we summarize the available evidence regarding the role of cathepsins in health and disease, discuss their potential as biomarkers of disease progression, and shed light on the potential of extracellular cathepsin inhibitors as safe therapeutic tools.

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“… 14 The low expression of CTSH was not conducive to the prognosis and led to a highest risk of death in patients with colorectal cancer. 15 Inversely, other investigations showed the undesirable effects of CTSH in cancers. Previous study showed the significant difference of CTSH level between lung tumor and non-tumorous tissues.…”

Section: Discussionmentioning

confidence: 99%

Favorable Prognostic Impact of Cathepsin H (CTSH) High Expression in Thyroid Carcinoma

Peng¹,

Chen²,

Zheng³

et al. 2021

IJGM

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Background: Presently, no study reported the function of cathepsin H (CTSH) in thyroid carcinoma (THCA). The aim of present study was to initially explore the factors affecting CTSH expression, and association between CTSH expression and survival rate in THCA. Methods: We explored mRNA expression of CTSH in normal and BRCA tissues, and evaluated prognostic impact of CTSH expression on the overall survival of THCA patients. Then, related factors influencing CTSH mRNA expression in THCA were analyzed. Functional enrichment analysis was performed to reveal the potential function of CTSH involved in THCA. We also constructed PPI network among co-expressed genes of CTSH to determine hub genes, followed by association analysis on hub genes with CTSH. Results: (1) CTSH mRNA was highly expressed in THCA compared with normal group (P<0.001). High expression of CTSH was conducive to the overall survival of THCA patients (P=0.0027). CTSH was then determined as an independent prognostic factor in THCA (P=0.024). (2) The mRNA expression of CTSH was statistically related to patient's histological type, N stage, T stage, tumor stage and sample type (all P<0.001). CTSH copy number variation and methylation also influenced its mRNA expression (all P<0.001). (3) Pathway analysis indicated that CTSH mainly participated in cancer-related pathways, such as hedgehog signaling pathway, cytokine-cytokine receptor interaction and JAK-STAT signaling pathway (all P<0.05). (4) The top 10 co-expressed genes in whole PPI network showed significant correlation with CTSH expression (all P<0.001). Conclusion: CTSH higher expression was observed in THCA, which caused a good prognosis of patients. CTSH expression might be regulated by multiple factors including clinical characteristic, methylation, copy number and other genes. This study demonstrated the clinical significance of CTSH in THCA, as well as revealed the potential pathway associated with CTSH involved in thyroid cancer.

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Serum Cathepsin H as a Potential Prognostic Marker in Patients with Colorectal Cancer

Cited by 24 publications

References 22 publications

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

Favorable Prognostic Impact of Cathepsin H (CTSH) High Expression in Thyroid Carcinoma

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