Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia

Azar, Madona; Basu, Arpita; Jenkins, Alicia J.; Nankervis, Alison; Hanssen, Kristian F.; Scholz, Hanne; Henriksen, Tore; Garg, Satish K.; Hammad, Samar M.; Scardo, James A.; Aston, Christopher E.; Lyons, Timothy J.

doi:10.2337/dc10-2145

Cited by 61 publications

(63 citation statements)

References 25 publications

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“…table 1) [32,33,34,35]. In the 5 published confounder-adjusted studies included in the analyses [16,17,30,35,36,37], 3 different 25(OH)D assays were used, and the threshold for low vitamin D status was defined as 37.5 nmol/l in 2 studies and 50 nmol/l in 3 studies.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis

et al. 2013

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Background/Aims: Vitamin D may protect from pre-eclampsia through influences on immune modulation and vascular function. To evaluate the role of vitamin D in the development of pre-eclampsia, we conducted a systematic review and meta-analysis including novel data from 2 large-scale epidemiological studies. Methods: PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for prospective observational studies of association between vitamin D supplementation or status (measured by maternal 25-hydroxyvitamin D, 25(OH)D) with a subsequent risk of pre-eclampsia, or randomised controlled trials using vitamin D supplementation to prevent pre-eclampsia. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) and the Avon Longitudinal Study of Parents and Children (ALSPAC) were included in meta-analyses with published studies. Results: Mothers receiving vitamin D supplementation earlier in pregnancy had lower odds of pre-eclampsia [pooled odds ratios (OR) 0.81 and 95% confidence interval (CI) 0.75-0.87, p = 2.4 × 10^-8, 2 studies] in the meta-analysis of published studies with HCCSCA. The meta-analysis of published studies with ALSPAC suggested an association between higher serum 25(OH)D levels and a reduced risk of pre-eclampsia (pooled OR 0.52 and 95% CI 0.30-0.89, p = 0.02, 6 studies). Randomised trials of supplementation were suggestive of protective association (pooled OR 0.66 and 95% CI 0.52-0.83, p = 0.001, 4 studies). Conclusions: This study suggests that low maternal serum 25(OH)D concentrations increase pre-eclampsia risk and that vitamin D supplementation lowers this risk. The quality of evidence is insufficient to determine a causal association, which highlights the need for adequately powered clinical trials.

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Section: Resultsmentioning

confidence: 99%

Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis

et al. 2013

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“…A number of investigators have recognized the potential role of vitamin D in preeclampsia (11, 13, 23–32). For example, Xu et al (11) conducted a retrospective study investigating both maternal IL-6 levels and vitamin D levels in the third trimester.…”

Section: Role Of Vitamin D In Preeclampsiamentioning

confidence: 99%

Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia

Smith

Kirkpatrick

Kovilam

et al. 2015

Expert Review of Clinical Immunology

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Summary Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia have been identified, including endothelial dysfunction, immunological dysregulation, and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.

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“…However, abnormalities arising earlier in pregnancy are also of interest and could provide additional predictive and mechanistic insights (including reasons for elevation of endoglin). In this regard, we recently showed that lower levels of ␤-carotene early in pregnancy are associated with subsequent PE in T1DM women (15).…”

mentioning

confidence: 99%

Plasma Lipoproteins and Preeclampsia in Women with Type 1 Diabetes: A Prospective Study

Basu¹,

Alaupovic²,

Wu³

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

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Context:In nondiabetic pregnancy, cross-sectional studies have shown associations between maternal dyslipidemia and preeclampsia (PE). In type 1 diabetes mellitus (T1DM), the prevalence of PE is increased 4-fold, but prospective associations with plasma lipoproteins are unknown. Objectives:The aim of this study was to define lipoprotein-related markers and potential mechanisms for PE in T1DM. Design and Settings:We conducted a multicenter prospective study in T1DM pregnancy. Patients:We studied 118 T1DM women (26 developed PE, 92 remained normotensive). Subjects were studied at three visits before PE onset [12.2 Ϯ 1.9, 21.6 Ϯ 1.5, and 31.5 Ϯ 1.7 wk gestation (means Ϯ SD)] and at term (37.6 Ϯ 2.0 wk). Nondiabetic normotensive pregnant women (n ϭ 21) were included for reference. Main Outcome Measures:Conventional lipid profiles, lipoprotein subclasses [defined by size (nuclear magnetic resonance) and by apolipoprotein content], serum apolipoproteins (ApoAI, ApoB, and ApoCIII), and lipolysis (ApoCIII ratio) were measured in T1DM women with and without subsequent PE. Results:In women with vs. without subsequent PE, at the first and/or second study visits: lowdensity lipoprotein (LDL)-cholesterol, particle concentrations of total LDL and large (but not small) LDL, serum ApoB, and ApoB:ApoAI ratio were all increased (P Ͻ 0.05); peripheral lipoprotein lipolysis was decreased (P Ͻ 0.01). These early differences remained significant in covariate analysis (glycated hemoglobin, actual prandial status, gravidity, body mass index, and diabetes duration) but were not present at the third study visit. High-density lipoprotein and very low-density lipoprotein subclasses did not differ between groups before PE onset. Conclusions:Early in pregnancy, increased cholesterol-rich lipoproteins and an index suggesting decreased peripheral lipolysis were associated with subsequent PE in T1DM women. Background maternal lipoprotein characteristics, perhaps masked by effects of late pregnancy, may influence PE risk.

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Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia

Cited by 61 publications

References 25 publications

Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis

Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis

Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia

Plasma Lipoproteins and Preeclampsia in Women with Type 1 Diabetes: A Prospective Study

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